TSC22D3 (TSC22 domain family member 3)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1831 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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TSC22 domain family member 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TSC22D3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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DIP, DSIPI, GILZ, TSC-22R |
Chromosome
Chromosome number
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X |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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Xq22.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects o |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q99576 | ||||||||||
Protein name | TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) | ||||||||||
Protein function | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-i | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Ubiquitously expressed, including in the fetal brain and liver (PubMed:26752201). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11313722, PubMed:12393603). Lower levels detected in heart and kidney (PubMed:11313722, PubM | ||||||||||
Sequence |
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Sequence length | 134 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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