TSC22D3 (TSC22 domain family member 3)

Gene

• Entrez ID: 1831
• Gene name: TSC22 domain family member 3
• Gene symbol: TSC22D3
• Synonyms (NCBI Gene): DIP, DSIPI, GILZ, TSC-22R
• Chromosome: X
• Chromosome location: Xq22.3
• Summary: This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects o

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004547	hsa-miR-18a-5p	qRT-PCR	19131573
MIRT004548	hsa-miR-124-3p	qRT-PCR	19131573
MIRT005359	hsa-miR-182-5p	Luciferase reporter assay, qRT-PCR	20656788
MIRT018941	hsa-miR-335-5p	Microarray	18185580
MIRT050637	hsa-miR-19b-3p	CLASH	23622248
MIRT042293	hsa-miR-484	CLASH	23622248
MIRT037722	hsa-miR-744-5p	CLASH	23622248
MIRT037102	hsa-miR-877-3p	CLASH	23622248
MIRT036322	hsa-miR-1229-3p	CLASH	23622248
MIRT509151	hsa-miR-6815-5p	PAR-CLIP	21572407
MIRT509150	hsa-miR-6865-5p	PAR-CLIP	21572407
MIRT509149	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509148	hsa-miR-676-5p	PAR-CLIP	21572407
MIRT509147	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT509146	hsa-miR-3165	PAR-CLIP	21572407
MIRT509145	hsa-miR-3691-5p	PAR-CLIP	21572407
MIRT509144	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509143	hsa-miR-6802-5p	PAR-CLIP	21572407
MIRT509142	hsa-miR-3924	PAR-CLIP	21572407
MIRT509141	hsa-miR-7159-5p	PAR-CLIP	21572407
MIRT509140	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT509139	hsa-miR-421	PAR-CLIP	21572407
MIRT465105	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT465104	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT465103	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT004547	hsa-miR-18a-5p	PAR-CLIP	21572407
MIRT465102	hsa-miR-18b-5p	PAR-CLIP	21572407
MIRT465100	hsa-miR-4735-3p	PAR-CLIP	21572407
MIRT465101	hsa-miR-499a-3p	PAR-CLIP	21572407
MIRT465099	hsa-miR-499b-3p	PAR-CLIP	21572407
MIRT465098	hsa-miR-4255	PAR-CLIP	21572407
MIRT465097	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT465096	hsa-miR-4639-3p	PAR-CLIP	21572407
MIRT365670	hsa-miR-124-5p	PAR-CLIP	21572407
MIRT465095	hsa-miR-6794-3p	PAR-CLIP	21572407
MIRT509151	hsa-miR-6815-5p	PAR-CLIP	23446348
MIRT509150	hsa-miR-6865-5p	PAR-CLIP	23446348
MIRT509149	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509148	hsa-miR-676-5p	PAR-CLIP	23446348
MIRT509147	hsa-miR-4764-5p	PAR-CLIP	23446348
MIRT509146	hsa-miR-3165	PAR-CLIP	23446348
MIRT509145	hsa-miR-3691-5p	PAR-CLIP	23446348
MIRT509144	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509143	hsa-miR-6802-5p	PAR-CLIP	23446348
MIRT509142	hsa-miR-3924	PAR-CLIP	23446348
MIRT509141	hsa-miR-7159-5p	PAR-CLIP	23446348
MIRT509140	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT509139	hsa-miR-421	PAR-CLIP	23446348
MIRT509151	hsa-miR-6815-5p	PAR-CLIP	23446348
MIRT509150	hsa-miR-6865-5p	PAR-CLIP	23446348
MIRT509149	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509148	hsa-miR-676-5p	PAR-CLIP	23446348
MIRT509147	hsa-miR-4764-5p	PAR-CLIP	23446348
MIRT509146	hsa-miR-3165	PAR-CLIP	23446348
MIRT509145	hsa-miR-3691-5p	PAR-CLIP	23446348
MIRT509144	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509143	hsa-miR-6802-5p	PAR-CLIP	23446348
MIRT509142	hsa-miR-3924	PAR-CLIP	23446348
MIRT509141	hsa-miR-7159-5p	PAR-CLIP	23446348
MIRT509140	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT509139	hsa-miR-421	PAR-CLIP	23446348
MIRT465105	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT465104	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT465103	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT004547	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT465102	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT465100	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT465101	hsa-miR-499a-3p	PAR-CLIP	23592263
MIRT465099	hsa-miR-499b-3p	PAR-CLIP	23592263
MIRT465098	hsa-miR-4255	PAR-CLIP	23592263
MIRT465097	hsa-miR-3613-3p	PAR-CLIP	23592263
MIRT465096	hsa-miR-4639-3p	PAR-CLIP	23592263
MIRT365670	hsa-miR-124-5p	PAR-CLIP	23592263
MIRT465095	hsa-miR-6794-3p	PAR-CLIP	23592263
MIRT465094	hsa-miR-3978	PAR-CLIP	23592263
MIRT509151	hsa-miR-6815-5p	PAR-CLIP	21572407
MIRT509150	hsa-miR-6865-5p	PAR-CLIP	21572407
MIRT509149	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509148	hsa-miR-676-5p	PAR-CLIP	21572407
MIRT509147	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT509146	hsa-miR-3165	PAR-CLIP	21572407
MIRT509145	hsa-miR-3691-5p	PAR-CLIP	21572407
MIRT509144	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509143	hsa-miR-6802-5p	PAR-CLIP	21572407
MIRT509142	hsa-miR-3924	PAR-CLIP	21572407
MIRT509141	hsa-miR-7159-5p	PAR-CLIP	21572407
MIRT509140	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT509139	hsa-miR-421	PAR-CLIP	21572407
MIRT465105	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT465104	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT465103	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT004547	hsa-miR-18a-5p	PAR-CLIP	21572407
MIRT465102	hsa-miR-18b-5p	PAR-CLIP	21572407
MIRT465100	hsa-miR-4735-3p	PAR-CLIP	21572407
MIRT465101	hsa-miR-499a-3p	PAR-CLIP	21572407
MIRT465099	hsa-miR-499b-3p	PAR-CLIP	21572407
MIRT465098	hsa-miR-4255	PAR-CLIP	21572407
MIRT465097	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT465096	hsa-miR-4639-3p	PAR-CLIP	21572407
MIRT365670	hsa-miR-124-5p	PAR-CLIP	21572407
MIRT465095	hsa-miR-6794-3p	PAR-CLIP	21572407
MIRT509151	hsa-miR-6815-5p	PAR-CLIP	23446348
MIRT509150	hsa-miR-6865-5p	PAR-CLIP	23446348
MIRT509149	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509148	hsa-miR-676-5p	PAR-CLIP	23446348
MIRT509147	hsa-miR-4764-5p	PAR-CLIP	23446348
MIRT509146	hsa-miR-3165	PAR-CLIP	23446348
MIRT509145	hsa-miR-3691-5p	PAR-CLIP	23446348
MIRT509144	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509143	hsa-miR-6802-5p	PAR-CLIP	23446348
MIRT509142	hsa-miR-3924	PAR-CLIP	23446348
MIRT509141	hsa-miR-7159-5p	PAR-CLIP	23446348
MIRT509140	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT509139	hsa-miR-421	PAR-CLIP	23446348
MIRT509151	hsa-miR-6815-5p	PAR-CLIP	23446348
MIRT509150	hsa-miR-6865-5p	PAR-CLIP	23446348
MIRT509149	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509148	hsa-miR-676-5p	PAR-CLIP	23446348
MIRT509147	hsa-miR-4764-5p	PAR-CLIP	23446348
MIRT509146	hsa-miR-3165	PAR-CLIP	23446348
MIRT509145	hsa-miR-3691-5p	PAR-CLIP	23446348
MIRT509144	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509143	hsa-miR-6802-5p	PAR-CLIP	23446348
MIRT509142	hsa-miR-3924	PAR-CLIP	23446348
MIRT509141	hsa-miR-7159-5p	PAR-CLIP	23446348
MIRT509140	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT509139	hsa-miR-421	PAR-CLIP	23446348
MIRT465105	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT465104	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT465103	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT004547	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT465102	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT465100	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT465101	hsa-miR-499a-3p	PAR-CLIP	23592263
MIRT465099	hsa-miR-499b-3p	PAR-CLIP	23592263
MIRT465098	hsa-miR-4255	PAR-CLIP	23592263
MIRT465097	hsa-miR-3613-3p	PAR-CLIP	23592263
MIRT465096	hsa-miR-4639-3p	PAR-CLIP	23592263
MIRT365670	hsa-miR-124-5p	PAR-CLIP	23592263
MIRT465095	hsa-miR-6794-3p	PAR-CLIP	23592263
MIRT465094	hsa-miR-3978	PAR-CLIP	23592263
MIRT1458361	hsa-miR-122	CLIP-seq
MIRT1458362	hsa-miR-1322	CLIP-seq
MIRT1458363	hsa-miR-2110	CLIP-seq
MIRT1458364	hsa-miR-3135b	CLIP-seq
MIRT1458365	hsa-miR-3150a-3p	CLIP-seq
MIRT1458366	hsa-miR-3175	CLIP-seq
MIRT1458367	hsa-miR-4726-3p	CLIP-seq
MIRT1458368	hsa-miR-4800-5p	CLIP-seq
MIRT1458369	hsa-miR-495	CLIP-seq
MIRT1458370	hsa-miR-711	CLIP-seq
MIRT1458371	hsa-miR-939	CLIP-seq
MIRT1458372	hsa-miR-3148	CLIP-seq
MIRT1458373	hsa-miR-3690	CLIP-seq
MIRT1458374	hsa-miR-4254	CLIP-seq
MIRT1458375	hsa-miR-4668-3p	CLIP-seq
MIRT1458376	hsa-miR-4698	CLIP-seq
MIRT1458377	hsa-miR-499-3p	CLIP-seq
MIRT1555196	hsa-miR-125a-3p	CLIP-seq
MIRT1555197	hsa-miR-1267	CLIP-seq
MIRT1555198	hsa-miR-127-5p	CLIP-seq
MIRT1555199	hsa-miR-2964a-5p	CLIP-seq
MIRT1555200	hsa-miR-3934	CLIP-seq
MIRT1555201	hsa-miR-4699-5p	CLIP-seq
MIRT1555202	hsa-miR-4709-3p	CLIP-seq
MIRT1555203	hsa-miR-653	CLIP-seq
MIRT1555204	hsa-miR-764	CLIP-seq
MIRT2137516	hsa-miR-1587	CLIP-seq
MIRT2137517	hsa-miR-188-3p	CLIP-seq
MIRT2137518	hsa-miR-221	CLIP-seq
MIRT2137519	hsa-miR-222	CLIP-seq
MIRT2137520	hsa-miR-3117-5p	CLIP-seq
MIRT1458372	hsa-miR-3148	CLIP-seq
MIRT2137521	hsa-miR-3611	CLIP-seq
MIRT2137522	hsa-miR-378g	CLIP-seq
MIRT2137523	hsa-miR-4492	CLIP-seq
MIRT2137524	hsa-miR-4498	CLIP-seq
MIRT2137525	hsa-miR-4656	CLIP-seq
MIRT1458375	hsa-miR-4668-3p	CLIP-seq
MIRT2137526	hsa-miR-4675	CLIP-seq
MIRT1458376	hsa-miR-4698	CLIP-seq
MIRT2137527	hsa-miR-4741	CLIP-seq
MIRT2137528	hsa-miR-4768-5p	CLIP-seq
MIRT2137529	hsa-miR-4786-3p	CLIP-seq
MIRT2137530	hsa-miR-762	CLIP-seq
MIRT2137531	hsa-miR-942	CLIP-seq
MIRT2358334	hsa-miR-103a	CLIP-seq
MIRT2358335	hsa-miR-107	CLIP-seq
MIRT2358336	hsa-miR-1204	CLIP-seq
MIRT2358337	hsa-miR-1207-3p	CLIP-seq
MIRT2358338	hsa-miR-1228	CLIP-seq
MIRT2358339	hsa-miR-1256	CLIP-seq
MIRT2358340	hsa-miR-1257	CLIP-seq
MIRT2358341	hsa-miR-1271	CLIP-seq
MIRT2358342	hsa-miR-1301	CLIP-seq
MIRT2358343	hsa-miR-1323	CLIP-seq
MIRT2358344	hsa-miR-15a	CLIP-seq
MIRT2358345	hsa-miR-15b	CLIP-seq
MIRT2358346	hsa-miR-16	CLIP-seq
MIRT2358347	hsa-miR-182	CLIP-seq
MIRT2358348	hsa-miR-195	CLIP-seq
MIRT1458363	hsa-miR-2110	CLIP-seq
MIRT2358349	hsa-miR-296-3p	CLIP-seq
MIRT2358350	hsa-miR-29a	CLIP-seq
MIRT2358351	hsa-miR-29b	CLIP-seq
MIRT2358352	hsa-miR-29c	CLIP-seq
MIRT2358353	hsa-miR-3065-3p	CLIP-seq
MIRT2137520	hsa-miR-3117-5p	CLIP-seq
MIRT2358354	hsa-miR-3138	CLIP-seq
MIRT2358355	hsa-miR-3153	CLIP-seq
MIRT2137521	hsa-miR-3611	CLIP-seq
MIRT2358356	hsa-miR-3614-5p	CLIP-seq
MIRT2358357	hsa-miR-3668	CLIP-seq
MIRT2358358	hsa-miR-3692	CLIP-seq
MIRT2137522	hsa-miR-378g	CLIP-seq
MIRT2358359	hsa-miR-3910	CLIP-seq
MIRT2358360	hsa-miR-424	CLIP-seq
MIRT2358361	hsa-miR-4271	CLIP-seq
MIRT2358362	hsa-miR-4276	CLIP-seq
MIRT2358363	hsa-miR-4520a-3p	CLIP-seq
MIRT2358364	hsa-miR-4642	CLIP-seq
MIRT2358365	hsa-miR-4667-5p	CLIP-seq
MIRT2358366	hsa-miR-4700-5p	CLIP-seq
MIRT2358367	hsa-miR-4708-3p	CLIP-seq
MIRT2358368	hsa-miR-4725-3p	CLIP-seq
MIRT1458367	hsa-miR-4726-3p	CLIP-seq
MIRT2358369	hsa-miR-4731-5p	CLIP-seq
MIRT2137528	hsa-miR-4768-5p	CLIP-seq
MIRT2137529	hsa-miR-4786-3p	CLIP-seq
MIRT2358370	hsa-miR-4790-3p	CLIP-seq
MIRT2358371	hsa-miR-488	CLIP-seq
MIRT2358372	hsa-miR-497	CLIP-seq
MIRT2358373	hsa-miR-5047	CLIP-seq
MIRT2358374	hsa-miR-541	CLIP-seq
MIRT2358375	hsa-miR-548o	CLIP-seq
MIRT2358376	hsa-miR-561	CLIP-seq
MIRT2358377	hsa-miR-629	CLIP-seq
MIRT2358378	hsa-miR-654-5p	CLIP-seq
MIRT2137531	hsa-miR-942	CLIP-seq
MIRT2358379	hsa-miR-96	CLIP-seq
MIRT2358380	hsa-miR-1197	CLIP-seq
MIRT2358341	hsa-miR-1271	CLIP-seq
MIRT2358381	hsa-miR-143	CLIP-seq
MIRT2358382	hsa-miR-3620	CLIP-seq
MIRT2137522	hsa-miR-378g	CLIP-seq
MIRT2358383	hsa-miR-4770	CLIP-seq
MIRT2358376	hsa-miR-561	CLIP-seq
MIRT2358379	hsa-miR-96	CLIP-seq
MIRT2358343	hsa-miR-1323	CLIP-seq
MIRT2358375	hsa-miR-548o	CLIP-seq
MIRT2358334	hsa-miR-103a	CLIP-seq
MIRT2358335	hsa-miR-107	CLIP-seq
MIRT2358337	hsa-miR-1207-3p	CLIP-seq
MIRT2358339	hsa-miR-1256	CLIP-seq
MIRT2358340	hsa-miR-1257	CLIP-seq
MIRT2358341	hsa-miR-1271	CLIP-seq
MIRT2358342	hsa-miR-1301	CLIP-seq
MIRT2358343	hsa-miR-1323	CLIP-seq
MIRT2137516	hsa-miR-1587	CLIP-seq
MIRT2358344	hsa-miR-15a	CLIP-seq
MIRT2358345	hsa-miR-15b	CLIP-seq
MIRT2358346	hsa-miR-16	CLIP-seq
MIRT2358347	hsa-miR-182	CLIP-seq
MIRT2137517	hsa-miR-188-3p	CLIP-seq
MIRT2358348	hsa-miR-195	CLIP-seq
MIRT1458363	hsa-miR-2110	CLIP-seq
MIRT2358349	hsa-miR-296-3p	CLIP-seq
MIRT2358350	hsa-miR-29a	CLIP-seq
MIRT2358351	hsa-miR-29b	CLIP-seq
MIRT2358352	hsa-miR-29c	CLIP-seq
MIRT2358353	hsa-miR-3065-3p	CLIP-seq
MIRT2137520	hsa-miR-3117-5p	CLIP-seq
MIRT2358354	hsa-miR-3138	CLIP-seq
MIRT2358355	hsa-miR-3153	CLIP-seq
MIRT2651609	hsa-miR-320a	CLIP-seq
MIRT2651610	hsa-miR-320b	CLIP-seq
MIRT2651611	hsa-miR-320c	CLIP-seq
MIRT2651612	hsa-miR-320d	CLIP-seq
MIRT2137521	hsa-miR-3611	CLIP-seq
MIRT2358357	hsa-miR-3668	CLIP-seq
MIRT2137522	hsa-miR-378g	CLIP-seq
MIRT2358359	hsa-miR-3910	CLIP-seq
MIRT2358360	hsa-miR-424	CLIP-seq
MIRT2358361	hsa-miR-4271	CLIP-seq
MIRT2358362	hsa-miR-4276	CLIP-seq
MIRT2651613	hsa-miR-4429	CLIP-seq
MIRT2137523	hsa-miR-4492	CLIP-seq
MIRT2137524	hsa-miR-4498	CLIP-seq
MIRT2358363	hsa-miR-4520a-3p	CLIP-seq
MIRT2358364	hsa-miR-4642	CLIP-seq
MIRT2137525	hsa-miR-4656	CLIP-seq
MIRT2358365	hsa-miR-4667-5p	CLIP-seq
MIRT2137526	hsa-miR-4675	CLIP-seq
MIRT2651614	hsa-miR-4700-3p	CLIP-seq
MIRT2358366	hsa-miR-4700-5p	CLIP-seq
MIRT2358367	hsa-miR-4708-3p	CLIP-seq
MIRT2358368	hsa-miR-4725-3p	CLIP-seq
MIRT2358369	hsa-miR-4731-5p	CLIP-seq
MIRT2137527	hsa-miR-4741	CLIP-seq
MIRT2137528	hsa-miR-4768-5p	CLIP-seq
MIRT2137529	hsa-miR-4786-3p	CLIP-seq
MIRT2358370	hsa-miR-4790-3p	CLIP-seq
MIRT2358372	hsa-miR-497	CLIP-seq
MIRT2358373	hsa-miR-5047	CLIP-seq
MIRT2358374	hsa-miR-541	CLIP-seq
MIRT2358375	hsa-miR-548o	CLIP-seq
MIRT2358377	hsa-miR-629	CLIP-seq
MIRT2358378	hsa-miR-654-5p	CLIP-seq
MIRT2137530	hsa-miR-762	CLIP-seq
MIRT2137531	hsa-miR-942	CLIP-seq
MIRT2358379	hsa-miR-96	CLIP-seq
MIRT1458363	hsa-miR-2110	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006970	Process	Response to osmotic stress	IEA
GO:0070236	Process	Negative regulation of activation-induced cell death of T cells	IBA
GO:0070236	Process	Negative regulation of activation-induced cell death of T cells	IEA

Other IDs

• MIM: 300506
• HGNC: 3051
• e!Ensembl: ENSG00000157514

Protein

• UniProt ID: Q99576
• Protein name: TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R)
• Protein function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-i
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01166	TSC22	58 → 114	TSC-22/dip/bun family	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed, including in the fetal brain and liver (PubMed:26752201). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11313722, PubMed:12393603). Lower levels detected in heart and kidney (PubMed:11313722, PubM
• Sequence:

  MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDL
  VKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAP
  ESPQVPEAPGGSAV

• Sequence length: 134

Pathways

Reactome:

Stimuli-sensing channels