ARID3A (AT-rich interaction domain 3A)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1820
Gene name Gene Name - the full gene name approved by the HGNC.
AT-rich interaction domain 3A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARID3A
Synonyms (NCBI Gene) Gene synonyms aliases
BRIGHT, DRIL1, DRIL3, E2FBP1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(528)
miRTarBase ID miRNA Experiments Reference
MIRT005059 hsa-let-7b-5p Microarray 17699775
MIRT023439 hsa-miR-30b-5p Sequencing 20371350
MIRT027857 hsa-miR-98-5p Microarray 19088304
MIRT032173 hsa-let-7d-5p Sequencing 20371350
MIRT042421 hsa-miR-425-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IBA 21873635
GO:0003682 Function Chromatin binding IEA
GO:0003712 Function Transcription coregulator activity IEA
GO:0005515 Function Protein binding IPI 19214191, 25416956, 32296183
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603265 3031 ENSG00000116017
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q99856
Protein name AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1)
Protein function Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
PDB 2KK0 , 4LJX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01388 ARID 240 → 326 ARID/BRIGHT DNA binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.
Sequence 
MKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAPDEDREPESARMQRAQMA
ALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASD
EDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPP
QAFRGDGVPRVLGGQERPGPGPAHPGGAAHVAPQLQPPDHGDWTYEEQFKQLYELDGDPK
RKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKG
LNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFA
YSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGH
PVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESAEPPEKKMALVADEQQRLMQRALQQ
NFLAMAAQLPMSIRINSQASESRQDSAVNLTGTNGSNSISMSVEINGIMYTGVLFAQPPA
PTPTSAPNKGGGGGGGSSSNAGGRGGNTGTSGGQAGPAGLSTPSTSTSNNSLP
Sequence length 593
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Biliary Cholangitis Biliary Cholangitis GWAS
Dermatitis Dermatitis GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Show/Hide Text Mining Associations (13)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 27809618
Cakut Associate 40774958
Carcinoma Hepatocellular Associate 27458175, 36008383
Fetal Growth Retardation Associate 31415216
Inflammation Associate 27522115, 30297159
Liver Cirrhosis Biliary Associate 28425483
Lupus Erythematosus Systemic Stimulate 25185498
Lupus Erythematosus Systemic Associate 26685208, 27522115, 30297159
Lymphoma Large B Cell Diffuse Associate 23424639
Migraine Disorders Associate 39833696