Gene Gene information from NCBI Gene database.
Entrez ID 1787
Gene name TRNA aspartic acid methyltransferase 1
Gene symbol TRDMT1
Synonyms (NCBI Gene)
DMNT2DNMT2MHSAIIPPUMETRNMT1
Chromosome 10
Chromosome location 10p13
Summary This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in se
miRNA miRNA information provided by mirtarbase database.
405
miRTarBase ID miRNA Experiments Reference
MIRT443221 hsa-miR-5692a PAR-CLIP 22100165
MIRT443220 hsa-miR-595 PAR-CLIP 22100165
MIRT443219 hsa-miR-648 PAR-CLIP 22100165
MIRT443218 hsa-miR-1227-3p PAR-CLIP 22100165
MIRT443221 hsa-miR-5692a PAR-CLIP 22100165
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0005634 Component Nucleus IBA
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IDA 16424344
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602478 2977 ENSG00000107614
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14717
Protein name tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet)
Protein function Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495).
PDB 1G55
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00145 DNA_methylase 4 391 C-5 cytosine-specific DNA methylase Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    tRNA modification in the nucleus and cytosol