Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1787
Gene name Gene Name - the full gene name approved by the HGNC.
TRNA aspartic acid methyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRDMT1
Synonyms (NCBI Gene) Gene synonyms aliases
DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in se
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT443221 hsa-miR-5692a PAR-CLIP 22100165
MIRT443220 hsa-miR-595 PAR-CLIP 22100165
MIRT443219 hsa-miR-648 PAR-CLIP 22100165
MIRT443218 hsa-miR-1227-3p PAR-CLIP 22100165
MIRT443221 hsa-miR-5692a PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0005634 Component Nucleus IBA
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IDA 16424344
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602478 2977 ENSG00000107614
Protein
UniProt ID O14717
Protein name tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet)
Protein function Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495).
PDB 1G55
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00145 DNA_methylase 4 391 C-5 cytosine-specific DNA methylase Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    tRNA modification in the nucleus and cytosol
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Cervical Cancer Cervical cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 35917687
COVID 19 Associate 38203569
DNA Virus Infections Associate 34139673
Glioblastoma Associate 34139673, 36273376, 37169948
Heart Defects Congenital Associate 28264803
Leukemia Associate 33331537
Leukemia Myeloid Acute Associate 33331537
Lymphoma Non Hodgkin Associate 33400376
Necrosis Associate 34139673
Neoplasms Associate 28843151, 34139673, 36273376, 37169948