AFM (afamin)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
173
Gene name Gene Name - the full gene name approved by the HGNC.
Afamin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AFM
Synonyms (NCBI Gene) Gene synonyms aliases
ALB2, ALBA, ALF
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. Th
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(18)
GO ID Ontology Definition Evidence Reference
GO:0005504 Function Fatty acid binding IBA 21873635
GO:0005515 Function Protein binding IPI 26902720
GO:0005576 Component Extracellular region TAS 7517938
GO:0005615 Component Extracellular space HDA 16502470
GO:0005615 Component Extracellular space IDA 12463752, 15952736, 19046407, 26902720
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
104145 316 ENSG00000079557
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID P43652
Protein name Afamin (Alpha-albumin) (Alpha-Alb)
Protein function Functions as a carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B
PDB 5OKL , 6FAK , 6RQ7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00273 Serum_albumin 30 → 202 Serum albumin family Domain
PF00273 Serum_albumin 222 → 394 Serum albumin family Domain
PF00273 Serum_albumin 414 → 590 Serum albumin family Domain
Tissue specificity TISSUE SPECIFICITY: High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level). {ECO:0000269|PubMed:12463752, ECO:0000269|PubMed:15952736, ECO:0000269|PubMed:7517938}.
Sequence
Sequence length 599
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate, Prostate carcinoma rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 23535732, 29892016
Show/Hide Text Mining Associations (26)
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 36793712
Alzheimer Disease Inhibit 35887259
Breast Neoplasms Associate 21871081, 31653553
COVID 19 Associate 37985892
Diabetes Gestational Associate 30917176
Endocrine System Diseases Inhibit 39342320
Fabry Disease Associate 25619383
Fatty Liver Associate 40250425
Heart Failure Inhibit 23981841
Inflammation Associate 23981841