GPHA2 (glycoprotein hormone subunit alpha 2)

Gene

• Entrez ID: 170589
• Gene name: Glycoprotein hormone subunit alpha 2
• Gene symbol: GPHA2
• Synonyms (NCBI Gene): A2, GPA2, ZSIG51
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT649023	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT649022	hsa-miR-764	HITS-CLIP	23824327
MIRT649021	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT649019	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT649020	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT649018	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT649017	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT649016	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT649015	hsa-miR-4518	HITS-CLIP	23824327
MIRT649014	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT649013	hsa-miR-3185	HITS-CLIP	23824327
MIRT649012	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT460403	hsa-miR-4476	PAR-CLIP	23592263
MIRT460402	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT460401	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT460400	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT460399	hsa-miR-1180-5p	PAR-CLIP	23592263
MIRT460398	hsa-miR-7114-3p	PAR-CLIP	23592263
MIRT460397	hsa-miR-4533	PAR-CLIP	23592263
MIRT460396	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT460394	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT460395	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT460393	hsa-miR-7973	PAR-CLIP	23592263
MIRT460392	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT649023	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT649022	hsa-miR-764	HITS-CLIP	23824327
MIRT649021	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT649019	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT649020	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT649018	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT649017	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT649016	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT649015	hsa-miR-4518	HITS-CLIP	23824327
MIRT649014	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT649013	hsa-miR-3185	HITS-CLIP	23824327
MIRT649012	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT460403	hsa-miR-4476	PAR-CLIP	23592263
MIRT460402	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT460401	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT460400	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT460399	hsa-miR-1180-5p	PAR-CLIP	23592263
MIRT460398	hsa-miR-7114-3p	PAR-CLIP	23592263
MIRT460397	hsa-miR-4533	PAR-CLIP	23592263
MIRT460396	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT460394	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT460395	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT460393	hsa-miR-7973	PAR-CLIP	23592263
MIRT460392	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT1029283	hsa-miR-1272	CLIP-seq
MIRT1029284	hsa-miR-3662	CLIP-seq
MIRT1029285	hsa-miR-583	CLIP-seq
MIRT2237992	hsa-miR-1207-5p	CLIP-seq
MIRT2237993	hsa-miR-145	CLIP-seq
MIRT2237994	hsa-miR-1827	CLIP-seq
MIRT2237995	hsa-miR-2467-3p	CLIP-seq
MIRT2237996	hsa-miR-3127-5p	CLIP-seq
MIRT2237997	hsa-miR-3154	CLIP-seq
MIRT2237998	hsa-miR-3667-3p	CLIP-seq
MIRT2237999	hsa-miR-3918	CLIP-seq
MIRT2238000	hsa-miR-4328	CLIP-seq
MIRT2238001	hsa-miR-4446-3p	CLIP-seq
MIRT2238002	hsa-miR-4448	CLIP-seq
MIRT2238003	hsa-miR-4514	CLIP-seq
MIRT2238004	hsa-miR-4640-5p	CLIP-seq
MIRT2238005	hsa-miR-4645-5p	CLIP-seq
MIRT2238006	hsa-miR-4673	CLIP-seq
MIRT2238007	hsa-miR-4692	CLIP-seq
MIRT2238008	hsa-miR-4726-5p	CLIP-seq
MIRT2238009	hsa-miR-4755-3p	CLIP-seq
MIRT2238010	hsa-miR-4763-3p	CLIP-seq
MIRT2238011	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005179	Function	Hormone activity	IEA
GO:0005515	Function	Protein binding	IPI	12045258
GO:0005576	Component	Extracellular region	IDA	12089349
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IMP	12045258
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	12045258
GO:0031531	Function	Thyrotropin-releasing hormone receptor binding	IBA
GO:0031531	Function	Thyrotropin-releasing hormone receptor binding	IMP	12045258
GO:0046982	Function	Protein heterodimerization activity	IDA	12045258

Other IDs

• MIM: 609651
• HGNC: 18054
• e!Ensembl: ENSG00000149735

Protein

• UniProt ID: Q96T91
• Protein name: Glycoprotein hormone alpha-2 (Putative secreted protein Zsig51) (Thyrostimulin subunit alpha)
• Protein function: Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell meta
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03045	DAN	16 → 124	DAN domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Found in a variety of tissues. {ECO:0000269|PubMed:12089349}.
• Sequence:

  MPMASPQTLVLYLLVLAVTEAWGQEAVIPGCHLHPFNVTVRSDRQGTCQGSHVAQACVGH
  CESSAFPSRYSVLVASGYRHNITSVSQCCTISGLKKVKVQLQCVGSRREELEIFTARACQ
  CDMCRLSRY

• Sequence length: 129

Pathways

KEGG:

cAMP signaling pathway
Neuroactive ligand-receptor interaction

Reactome:

Hormone ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production