GIMAP1 (GTPase, IMAP family member 1)

Gene

• Entrez ID: 170575
• Gene name: GTPase, IMAP family member 1
• Gene symbol: GIMAP1
• Synonyms (NCBI Gene): HIMAP1, IAN2, IMAP1, IMAP38
• Chromosome: 7
• Chromosome location: 7q36.1
• Summary: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	23824327
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	23824327
MIRT608957	hsa-miR-3689e	HITS-CLIP	23824327
MIRT608956	hsa-miR-3689f	HITS-CLIP	23824327
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608953	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	24906430
MIRT608961	hsa-miR-892a	HITS-CLIP	24906430
MIRT608960	hsa-miR-4494	HITS-CLIP	24906430
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	24906430
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	24906430
MIRT608957	hsa-miR-3689e	HITS-CLIP	24906430
MIRT608956	hsa-miR-3689f	HITS-CLIP	24906430
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608953	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT608957	hsa-miR-3689e	HITS-CLIP	27418678
MIRT608957	hsa-miR-3689e	HITS-CLIP	27418678
MIRT608957	hsa-miR-3689e	HITS-CLIP	27418678
MIRT608956	hsa-miR-3689f	HITS-CLIP	27418678
MIRT608956	hsa-miR-3689f	HITS-CLIP	27418678
MIRT608956	hsa-miR-3689f	HITS-CLIP	27418678
MIRT608960	hsa-miR-4494	HITS-CLIP	27418678
MIRT608960	hsa-miR-4494	HITS-CLIP	27418678
MIRT608960	hsa-miR-4494	HITS-CLIP	27418678
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	27418678
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	27418678
MIRT608953	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608953	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608953	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608961	hsa-miR-892a	HITS-CLIP	27418678
MIRT608961	hsa-miR-892a	HITS-CLIP	27418678
MIRT608962	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT608959	hsa-miR-3689a-5p	HITS-CLIP	23824327
MIRT608958	hsa-miR-3689b-5p	HITS-CLIP	23824327
MIRT608957	hsa-miR-3689e	HITS-CLIP	23824327
MIRT608956	hsa-miR-3689f	HITS-CLIP	23824327
MIRT608955	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608954	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608953	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1018887	hsa-miR-122	CLIP-seq
MIRT1018888	hsa-miR-1248	CLIP-seq
MIRT1018889	hsa-miR-1254	CLIP-seq
MIRT1018890	hsa-miR-125a-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018892	hsa-miR-1307	CLIP-seq
MIRT1018893	hsa-miR-217	CLIP-seq
MIRT1018894	hsa-miR-3116	CLIP-seq
MIRT1018895	hsa-miR-3127-3p	CLIP-seq
MIRT1018896	hsa-miR-3140-5p	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018898	hsa-miR-3155	CLIP-seq
MIRT1018899	hsa-miR-3155b	CLIP-seq
MIRT1018900	hsa-miR-3166	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018902	hsa-miR-3663-5p	CLIP-seq
MIRT1018903	hsa-miR-3678-3p	CLIP-seq
MIRT1018904	hsa-miR-3915	CLIP-seq
MIRT1018905	hsa-miR-3928	CLIP-seq
MIRT1018906	hsa-miR-3934	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018908	hsa-miR-4254	CLIP-seq
MIRT1018909	hsa-miR-4258	CLIP-seq
MIRT1018910	hsa-miR-4284	CLIP-seq
MIRT1018911	hsa-miR-4495	CLIP-seq
MIRT1018912	hsa-miR-451b	CLIP-seq
MIRT1018913	hsa-miR-4638-5p	CLIP-seq
MIRT1018914	hsa-miR-4663	CLIP-seq
MIRT1018915	hsa-miR-4711-5p	CLIP-seq
MIRT1018916	hsa-miR-4713-5p	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018919	hsa-miR-4766-3p	CLIP-seq
MIRT1018920	hsa-miR-4771	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT1018922	hsa-miR-4778-3p	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT1018924	hsa-miR-4790-3p	CLIP-seq
MIRT1018925	hsa-miR-484	CLIP-seq
MIRT1018926	hsa-miR-514	CLIP-seq
MIRT1018927	hsa-miR-514b-3p	CLIP-seq
MIRT1018928	hsa-miR-548a-3p	CLIP-seq
MIRT1018929	hsa-miR-548e	CLIP-seq
MIRT1018930	hsa-miR-548f	CLIP-seq
MIRT1018931	hsa-miR-548g	CLIP-seq
MIRT1018932	hsa-miR-564	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT1018934	hsa-miR-640	CLIP-seq
MIRT1018935	hsa-miR-764	CLIP-seq
MIRT1018890	hsa-miR-125a-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018898	hsa-miR-3155	CLIP-seq
MIRT1018899	hsa-miR-3155b	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018902	hsa-miR-3663-5p	CLIP-seq
MIRT1018906	hsa-miR-3934	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT1018925	hsa-miR-484	CLIP-seq
MIRT1018934	hsa-miR-640	CLIP-seq
MIRT1018935	hsa-miR-764	CLIP-seq
MIRT1018887	hsa-miR-122	CLIP-seq
MIRT1018889	hsa-miR-1254	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018892	hsa-miR-1307	CLIP-seq
MIRT2001675	hsa-miR-150	CLIP-seq
MIRT1018893	hsa-miR-217	CLIP-seq
MIRT1018894	hsa-miR-3116	CLIP-seq
MIRT2001676	hsa-miR-3147	CLIP-seq
MIRT1018898	hsa-miR-3155	CLIP-seq
MIRT1018899	hsa-miR-3155b	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018902	hsa-miR-3663-5p	CLIP-seq
MIRT2001677	hsa-miR-3942-3p	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018908	hsa-miR-4254	CLIP-seq
MIRT1018910	hsa-miR-4284	CLIP-seq
MIRT2001678	hsa-miR-4425	CLIP-seq
MIRT2001679	hsa-miR-4446-5p	CLIP-seq
MIRT2001680	hsa-miR-450b-3p	CLIP-seq
MIRT2001681	hsa-miR-4520a-3p	CLIP-seq
MIRT1018913	hsa-miR-4638-5p	CLIP-seq
MIRT1018915	hsa-miR-4711-5p	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT1018925	hsa-miR-484	CLIP-seq
MIRT2001682	hsa-miR-520g	CLIP-seq
MIRT2001683	hsa-miR-520h	CLIP-seq
MIRT1018932	hsa-miR-564	CLIP-seq
MIRT2001684	hsa-miR-769-3p	CLIP-seq
MIRT2001685	hsa-miR-938	CLIP-seq
MIRT1018887	hsa-miR-122	CLIP-seq
MIRT1018889	hsa-miR-1254	CLIP-seq
MIRT1018892	hsa-miR-1307	CLIP-seq
MIRT1018894	hsa-miR-3116	CLIP-seq
MIRT2234751	hsa-miR-3173-3p	CLIP-seq
MIRT2234752	hsa-miR-3184	CLIP-seq
MIRT2234753	hsa-miR-3194-3p	CLIP-seq
MIRT2234754	hsa-miR-3907	CLIP-seq
MIRT2234755	hsa-miR-423-5p	CLIP-seq
MIRT1018908	hsa-miR-4254	CLIP-seq
MIRT1018913	hsa-miR-4638-5p	CLIP-seq
MIRT2234756	hsa-miR-4688	CLIP-seq
MIRT2234757	hsa-miR-4779	CLIP-seq
MIRT1018932	hsa-miR-564	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT2538737	hsa-miR-1208	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT2538738	hsa-miR-3064-3p	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT2538739	hsa-miR-3653	CLIP-seq
MIRT2538740	hsa-miR-3658	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT2538741	hsa-miR-4252	CLIP-seq
MIRT2538742	hsa-miR-4317	CLIP-seq
MIRT2538743	hsa-miR-4715-3p	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT2538744	hsa-miR-4760-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq
MIRT1018891	hsa-miR-1273f	CLIP-seq
MIRT1018897	hsa-miR-3149	CLIP-seq
MIRT1018901	hsa-miR-3170	CLIP-seq
MIRT1018907	hsa-miR-411	CLIP-seq
MIRT1018917	hsa-miR-4716-5p	CLIP-seq
MIRT1018918	hsa-miR-4735-5p	CLIP-seq
MIRT1018921	hsa-miR-4775	CLIP-seq
MIRT1018923	hsa-miR-4781-3p	CLIP-seq
MIRT2450258	hsa-miR-4794	CLIP-seq
MIRT1018933	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005525	Function	GTP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 608084
• HGNC: 23237
• e!Ensembl: ENSG00000213203

Protein

• UniProt ID: Q8WWP7
• Protein name: GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1)
• Protein function: May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).
• PDB: 3V70
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04548	AIG1	28 → 238	AIG1 family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Detected in T-cells. {ECO:0000269|PubMed:11814688, ECO:0000269|PubMed:23454188}.
• Sequence:

  MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGAT
  SVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQ
  LGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAE
  CGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERL
  RRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAV
  AEVGPD

• Sequence length: 306