Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
170572
Gene name Gene Name - the full gene name approved by the HGNC.
5-hydroxytryptamine receptor 3C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HTR3C
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q27.1
Summary Summary of gene provided in NCBI Entrez Gene.
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitoge
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1057256 hsa-miR-1202 CLIP-seq
MIRT1057257 hsa-miR-3972 CLIP-seq
MIRT1057258 hsa-miR-4776-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0005515 Function Protein binding IPI 17392525
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0007165 Process Signal transduction IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610121 24003 ENSG00000178084
Protein
UniProt ID Q8WXA8
Protein name 5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C)
Protein function Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02931 Neur_chan_LBD 44 247 Neurotransmitter-gated ion-channel ligand binding domain Family
PF02932 Neur_chan_memb 254 373 Neurotransmitter-gated ion-channel transmembrane region Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. {ECO:0000269|PubMed:12801637}.
Sequence
Sequence length 447
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Serotonergic synapse
Taste transduction
  Neurotransmitter receptors and postsynaptic signal transmission
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
19035560
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Associations from Text Mining
Disease Name Relationship Type References
Anxiety Associate 35800179
Autism Spectrum Disorder Associate 19035560
Autistic Disorder Associate 19035560
Depressive Disorder Associate 35800179
Dyspepsia Associate 21192076
Hidradenitis Suppurativa Associate 39940809
Irritable Bowel Syndrome Associate 31342534, 35800179
Obsessive Compulsive Disorder Associate 27616601
Postoperative Nausea and Vomiting Associate 18389280, 27803457, 37924126
Vomiting Associate 18389280