DEFA4 (defensin alpha 4)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1669
Gene name Gene Name - the full gene name approved by the HGNC.
Defensin alpha 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DEFA4
Synonyms (NCBI Gene) Gene synonyms aliases
DEF4, HNP-4, HP-4, HP4
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p23.1
Summary Summary of gene provided in NCBI Entrez Gene.
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract,
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT017503 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(33)
GO ID Ontology Definition Evidence Reference
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
GO:0005615 Component Extracellular space IEA
GO:0005796 Component Golgi lumen IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
601157 2763 ENSG00000164821
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways
UniProt ID P12838
Protein name Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4)
Protein function Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (PubMed:15317502, PubMed:15616305, PubMed:2500436, PubMed:2501794, PubMed:30658057). Exhibi
PDB 1ZMM , 6DMM , 6DMQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00879 Defensin_propep 1 → 51 Defensin propeptide Family
PF00323 Defensin_1 65 → 93 Mammalian defensin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in neutrophils (at protein level) (PubMed:2500436, PubMed:2501794, PubMed:2843187). Expressed in bone marrow (PubMed:8469233). {ECO:0000269|PubMed:2500436, ECO:0000269|PubMed:2501794, ECO:0000269|PubMed:2843187, ECO:0000269|P
Sequence
Sequence length 97
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  NOD-like receptor signaling pathway
Staphylococcus aureus infection
Transcriptional misregulation in cancer 		  Defensins
Alpha-defensins
Neutrophil degranulation
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