Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
163
Gene name Gene Name - the full gene name approved by the HGNC.
Adaptor related protein complex 2 subunit beta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AP2B1
Synonyms (NCBI Gene) Gene synonyms aliases
ADTB2, AP105B, AP2-BETA, CLAPB1
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma m
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025304 hsa-miR-34a-5p Proteomics 21566225
MIRT025304 hsa-miR-34a-5p Proteomics 21566225
MIRT025304 hsa-miR-34a-5p Proteomics 21566225
MIRT031985 hsa-miR-16-5p Proteomics 18668040
MIRT050627 hsa-miR-19b-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001822 Process Kidney development IEA
GO:0003281 Process Ventricular septum development IEA
GO:0005048 Function Signal sequence binding TAS 12121421
GO:0005515 Function Protein binding IPI 9341158, 12086608, 12221107, 15533940, 16189514, 20603002, 23676497, 24130457, 24189400, 25061211, 25416956, 26680585, 29892012, 30021884
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601025 563 ENSG00000006125
Protein
UniProt ID P63010
Protein name AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin
Protein function Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be invo
PDB 1E42 , 2G30 , 2IV8 , 2IV9 , 2JKR , 2JKT , 2VGL , 2XA7 , 4UQI , 5M5R , 6QH5 , 6QH6 , 6QH7 , 6URI , 6YAE , 6YAF , 6YAH , 6YAI , 7OG1 , 7OHO , 7OM8 , 7Z5C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01602 Adaptin_N 10 534 Adaptin N terminal region Family
PF02883 Alpha_adaptinC2 711 817 Adaptin C-terminal domain Domain
PF09066 B2-adapt-app_C 827 935 Beta2-adaptin appendage, C-terminal sub-domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the brain (at protein level). {ECO:0000269|PubMed:23676497}.
Sequence
MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT
DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA
VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI
CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY
VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK
YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP
VTAKEV
VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST
DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL
DSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKA
KGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQ
SIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFS
CLIPLNVLFVEDGKMERQVFLAT
WKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWIL
AELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSIL
KN
Sequence length 937
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
Synaptic vesicle cycle
Endocrine and other factor-regulated calcium reabsorption
Huntington disease
  Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31374203
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 27321098, 30680517
Acute Coronary Syndrome Associate 26670794, 29141503, 31195108
Acute Kidney Injury Associate 21103678
Acute Lung Injury Associate 21742477
Adenocarcinoma Associate 37002266
Albuminuria Associate 19720797, 34246281, 8587251, 8840299
Alzheimer Disease Associate 18076107, 19105203, 21232827, 21297258, 26884824, 28099631, 28865943, 29777097, 31521194, 31585107, 33541420, 36411364, 36759259, 36951251
Alzheimer Disease Stimulate 18830724
Amyotrophic Lateral Sclerosis Associate 33417599
Aneurysm Ascending Aorta Associate 19580662