Gene Gene information from NCBI Gene database.
Entrez ID 163
Gene name Adaptor related protein complex 2 subunit beta 1
Gene symbol AP2B1
Synonyms (NCBI Gene)
ADTB2AP105BAP2-BETACLAPB1
Chromosome 17
Chromosome location 17q12
Summary The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma m
miRNA miRNA information provided by mirtarbase database.
1200
miRTarBase ID miRNA Experiments Reference
MIRT025304 hsa-miR-34a-5p Proteomics 21566225
MIRT025304 hsa-miR-34a-5p Proteomics 21566225
MIRT025304 hsa-miR-34a-5p Proteomics 21566225
MIRT031985 hsa-miR-16-5p Proteomics 18668040
MIRT050627 hsa-miR-19b-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
63
GO ID Ontology Definition Evidence Reference
GO:0001822 Process Kidney development IEA
GO:0003279 Process Cardiac septum development IEA
GO:0003281 Process Ventricular septum development IEA
GO:0005048 Function Signal sequence binding TAS 12121421
GO:0005515 Function Protein binding IPI 9341158, 12086608, 12221107, 15533940, 16189514, 18654987, 20603002, 23676497, 24130457, 24189400, 24722188, 25061211, 25416956, 25910212, 26680585, 27107012, 29892012, 30021884, 32296183, 32814053, 33961781, 35044719, 35271311
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601025 563 ENSG00000006125
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63010
Protein name AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin
Protein function Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be invo
PDB 1E42 , 2G30 , 2IV8 , 2IV9 , 2JKR , 2JKT , 2VGL , 2XA7 , 4UQI , 5M5R , 6QH5 , 6QH6 , 6QH7 , 6URI , 6YAE , 6YAF , 6YAH , 6YAI , 7OG1 , 7OHO , 7OM8 , 7Z5C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01602 Adaptin_N 10 534 Adaptin N terminal region Family
PF02883 Alpha_adaptinC2 711 817 Adaptin C-terminal domain Domain
PF09066 B2-adapt-app_C 827 935 Beta2-adaptin appendage, C-terminal sub-domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the brain (at protein level). {ECO:0000269|PubMed:23676497}.
Sequence
MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT
DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA
VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI
CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY
VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK
YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP
VTAKEV
VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST
DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL
DSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKA
KGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQ
SIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFS
CLIPLNVLFVEDGKMERQVFLAT
WKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWIL
AELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSIL
KN
Sequence length 937
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
Synaptic vesicle cycle
Endocrine and other factor-regulated calcium reabsorption
Huntington disease
  Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance