DAZ1 (deleted in azoospermia 1)

Gene

• Entrez ID: 1617
• Gene name: Deleted in azoospermia 1
• Gene symbol: DAZ1
• Synonyms (NCBI Gene): DAZ, SPGY
• Chromosome: Y
• Chromosome location: Yq11.223
• Summary: This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT923309	hsa-let-7a	CLIP-seq
MIRT923310	hsa-let-7b	CLIP-seq
MIRT923311	hsa-let-7c	CLIP-seq
MIRT923312	hsa-let-7d	CLIP-seq
MIRT923313	hsa-let-7e	CLIP-seq
MIRT923314	hsa-let-7f	CLIP-seq
MIRT923315	hsa-let-7g	CLIP-seq
MIRT923316	hsa-let-7i	CLIP-seq
MIRT923317	hsa-miR-1270	CLIP-seq
MIRT923318	hsa-miR-1304	CLIP-seq
MIRT923319	hsa-miR-202	CLIP-seq
MIRT923320	hsa-miR-203	CLIP-seq
MIRT923321	hsa-miR-3140-3p	CLIP-seq
MIRT923322	hsa-miR-3140-5p	CLIP-seq
MIRT923323	hsa-miR-3682-5p	CLIP-seq
MIRT923324	hsa-miR-3923	CLIP-seq
MIRT923325	hsa-miR-4276	CLIP-seq
MIRT923326	hsa-miR-4302	CLIP-seq
MIRT923327	hsa-miR-432	CLIP-seq
MIRT923328	hsa-miR-4434	CLIP-seq
MIRT923329	hsa-miR-4458	CLIP-seq
MIRT923330	hsa-miR-4500	CLIP-seq
MIRT923331	hsa-miR-4516	CLIP-seq
MIRT923332	hsa-miR-4531	CLIP-seq
MIRT923333	hsa-miR-4733-5p	CLIP-seq
MIRT923334	hsa-miR-4766-5p	CLIP-seq
MIRT923335	hsa-miR-4777-5p	CLIP-seq
MIRT923336	hsa-miR-513a-3p	CLIP-seq
MIRT923337	hsa-miR-518d-5p	CLIP-seq
MIRT923338	hsa-miR-519b-5p	CLIP-seq
MIRT923339	hsa-miR-519c-5p	CLIP-seq
MIRT923340	hsa-miR-520c-5p	CLIP-seq
MIRT923341	hsa-miR-526a	CLIP-seq
MIRT923342	hsa-miR-548u	CLIP-seq
MIRT923343	hsa-miR-561	CLIP-seq
MIRT923344	hsa-miR-606	CLIP-seq
MIRT923345	hsa-miR-620	CLIP-seq
MIRT923346	hsa-miR-628-3p	CLIP-seq
MIRT923347	hsa-miR-98	CLIP-seq
MIRT923325	hsa-miR-4276	CLIP-seq
MIRT923326	hsa-miR-4302	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IBA
GO:0003730	Function	MRNA 3'-UTR binding	IEA
GO:0005515	Function	Protein binding	IPI	10857750, 12511597, 15081113, 16001084
GO:0005634	Component	Nucleus	IDA	15081113
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15081113, 31429579
GO:0005737	Component	Cytoplasm	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008494	Function	Translation activator activity	IBA
GO:0008494	Function	Translation activator activity	IDA	16001084
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	10857750
GO:0032991	Component	Protein-containing complex	IEA
GO:0045948	Process	Positive regulation of translational initiation	IBA
GO:0045948	Process	Positive regulation of translational initiation	IDA	16001084
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IBA

Other IDs

• MIM: 400003
• HGNC: 2682
• e!Ensembl: ENSG00000188120

Protein

• UniProt ID: Q9NQZ3
• Protein name: Deleted in azoospermia protein 1
• Protein function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells. {ECO:0000269|PubMed:1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	42 → 109	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	207 → 274	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	372 → 439	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF18872	Daz	500 → 520	Daz repeat	Repeat
  PF18872	Daz	524 → 544	Daz repeat	Repeat
  PF18872	Daz	548 → 568	Daz repeat	Repeat
  PF18872	Daz	572 → 592	Daz repeat	Repeat
  PF18872	Daz	596 → 616	Daz repeat	Repeat
  PF18872	Daz	620 → 640	Daz repeat	Repeat
  PF18872	Daz	644 → 664	Daz repeat	Repeat
  PF18872	Daz	668 → 688	Daz repeat	Repeat
  PF18872	Daz	692 → 712	Daz repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level). {ECO:0000269|PubMed:10936047, ECO:0000269|PubMed:18385127, ECO:0000269|PubMed:19223287}.
• Sequence:

  MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF
  GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC
  ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISR
  EASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNR
  TGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPP
  PPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGW
  VLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVND
  VDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTET
  YLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPV
  YNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSS
  PFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPV
  YNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVG
  EQRRNLWTEAYKWWYLVCLIQRRD

• Sequence length: 744