Gene Gene information from NCBI Gene database.
Entrez ID 160897
Gene name G protein-coupled receptor 180
Gene symbol GPR180
Synonyms (NCBI Gene)
ITR
Chromosome 13
Chromosome location 13q32.1
Summary This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq
miRNA miRNA information provided by mirtarbase database.
585
miRTarBase ID miRNA Experiments Reference
MIRT024681 hsa-miR-215-5p Microarray 19074876
MIRT026775 hsa-miR-192-5p Microarray 19074876
MIRT027173 hsa-miR-103a-3p Sequencing 20371350
MIRT031916 hsa-miR-16-5p Sequencing 20371350
MIRT668067 hsa-miR-627-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0006091 Process Generation of precursor metabolites and energy IEA
GO:0006629 Process Lipid metabolic process IEA
GO:0007186 Process G protein-coupled receptor signaling pathway IEA
GO:0010467 Process Gene expression IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607787 28899 ENSG00000152749
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86V85
Protein name Integral membrane protein GPR180 (Intimal thickness-related receptor)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10192 GpcrRhopsn4 141 405 Rhodopsin-like GPCR transmembrane domain Family
Sequence
Sequence length 440
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
11
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
GPR180-related disorder Benign; Likely benign rs139988296, rs12429818, rs74900909, rs113947424, rs181046554, rs9524559, rs562927203, rs1001952172, rs138194098, rs140472784 RCV003919643
RCV003974725
RCV003979709
RCV003911839
RCV003903952
RCV003977354
RCV003941386
RCV003934674
RCV003954439
RCV003962019
Lung cancer Benign rs139988296 RCV005938624
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Hepatoblastoma Associate 26991471
Hypertriglyceridemia Associate 31868224
Microcoria congenital Associate 32200002
Neoplasms Inhibit 26991471
Vascular Remodeling Associate 23940718