Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	160364
Gene name Gene Name - the full gene name approved by the HGNC.	C-type lectin domain family 12 member A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CLEC12A
Synonyms (NCBI Gene) Gene synonyms aliases	CD371, CLL-1, CLL1, DCAL-2, MICL, hKLRL1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.31-p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles i

Show/Hide all(55)

miRTarBase ID	miRNA	Experiments	Reference
MIRT550172	hsa-miR-8485	HITS-CLIP	21572407
MIRT550173	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT550171	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT550170	hsa-miR-603	HITS-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707162	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT707161	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT707160	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT550167	hsa-miR-3941	HITS-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550172	hsa-miR-8485	PAR-CLIP	21572407
MIRT550173	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT550171	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT550170	hsa-miR-603	PAR-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550167	hsa-miR-3941	PAR-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT550172	hsa-miR-8485	HITS-CLIP	21572407
MIRT550173	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT550171	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT550170	hsa-miR-603	HITS-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707162	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT707161	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT707160	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT550167	hsa-miR-3941	HITS-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550172	hsa-miR-8485	PAR-CLIP	21572407
MIRT550173	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT550171	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT550170	hsa-miR-603	PAR-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550167	hsa-miR-3941	PAR-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT895605	hsa-miR-127-5p	CLIP-seq
MIRT895606	hsa-miR-128	CLIP-seq
MIRT895607	hsa-miR-27a	CLIP-seq
MIRT895608	hsa-miR-27b	CLIP-seq
MIRT895609	hsa-miR-3119	CLIP-seq
MIRT895610	hsa-miR-3921	CLIP-seq
MIRT895611	hsa-miR-4653-5p	CLIP-seq
MIRT895612	hsa-miR-4768-5p	CLIP-seq
MIRT895613	hsa-miR-513a-5p	CLIP-seq
MIRT2201502	hsa-miR-4640-3p	CLIP-seq
MIRT2201503	hsa-miR-483-3p	CLIP-seq
MIRT2504454	hsa-miR-3121-5p	CLIP-seq
MIRT2504454	hsa-miR-3121-5p	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002283	Process	Neutrophil activation involved in immune response	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	38367667, 38386511, 39143217
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IMP	15238421
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14739280, 15238421, 16239426, 34234773, 38367667
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030545	Function	Signaling receptor regulator activity	IEA
GO:0032481	Process	Positive regulation of type I interferon production	ISS
GO:0032815	Process	Negative regulation of natural killer cell activation	IEA
GO:0032815	Process	Negative regulation of natural killer cell activation	IMP	15238421, 31269448
GO:0035579	Component	Specific granule membrane	TAS
GO:0038187	Function	Pattern recognition receptor activity	IDA	36542980
GO:0038187	Function	Pattern recognition receptor activity	IEA
GO:0038187	Function	Pattern recognition receptor activity	IMP	31269448
GO:0050728	Process	Negative regulation of inflammatory response	ISS
GO:0050777	Process	Negative regulation of immune response	IDA	14739280
GO:0070821	Component	Tertiary granule membrane	TAS
GO:1902564	Process	Negative regulation of neutrophil activation	IDA	34234773
GO:1902564	Process	Negative regulation of neutrophil activation	IEA
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IDA	16239426
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IEA

MIM	HGNC	e!Ensembl
612088	31713	ENSG00000172322

Protein

UniProt ID

Q5QGZ9

Protein name

C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)

Protein function

Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217). Myeloid cell inhibiti

PDB

8JAH , 8W8T , 8W9J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00059	Lectin_C	150 → 250	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Preferentially expressed in lymphoid tissues and immune cells, including natural killer (NK) cells, T-cells, dendritic cells and monocytes or macrophages (PubMed:14739280, PubMed:15238421, PubMed:15548716, PubMed:16239426, PubMed:16838

Sequence

MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVL
ASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRE
LYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFI
KSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHC
TYKKRMICEKMANPVQLGSTYFREA

Sequence length

265

Interactions

View interactions

	Reactome
			Neutrophil degranulation

CLEC12A (C-type lectin domain family 12 member A)