CLEC12A (C-type lectin domain family 12 member A)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
160364
Gene name Gene Name - the full gene name approved by the HGNC.
C-type lectin domain family 12 member A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CLEC12A
Synonyms (NCBI Gene) Gene synonyms aliases
CD371, CLL-1, CLL1, DCAL-2, MICL, hKLRL1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.31-p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles i
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(55)
miRTarBase ID miRNA Experiments Reference
MIRT550172 hsa-miR-8485 HITS-CLIP 21572407
MIRT550173 hsa-miR-329-3p HITS-CLIP 21572407
MIRT550171 hsa-miR-362-3p HITS-CLIP 21572407
MIRT550170 hsa-miR-603 HITS-CLIP 21572407
MIRT550168 hsa-miR-4789-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane TAS
GO:0016021 Component Integral component of membrane IEA
GO:0030246 Function Carbohydrate binding IEA
GO:0030545 Function Receptor regulator activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
612088 31713 ENSG00000172322
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q5QGZ9
Protein name C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)
Protein function Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217). Myeloid cell inhibiti
PDB 8JAH , 8W8T , 8W9J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00059 Lectin_C 150 → 250 Lectin C-type domain Domain
Tissue specificity TISSUE SPECIFICITY: Preferentially expressed in lymphoid tissues and immune cells, including natural killer (NK) cells, T-cells, dendritic cells and monocytes or macrophages (PubMed:14739280, PubMed:15238421, PubMed:15548716, PubMed:16239426, PubMed:16838
Sequence 
MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVL
ASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRE
LYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFI
KSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHC
TYKKRMICEKMANPVQLGSTYFREA
Sequence length 265
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 17568789
Show/Hide Text Mining Associations (27)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Associate 34045571, 34638548
Arthritis Rheumatoid Associate 34045571, 38302188
Behcet Syndrome Associate 37102643
COVID 19 Associate 36928077
Epilepsy Associate 34555062
Fibrosis Associate 38302188
Gout Associate 34638548
Hereditary Autoinflammatory Diseases Inhibit 34638548
Inflammation Inhibit 26890122, 34045571, 34638548
Inflammation Associate 34045571, 37102643