Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	160364
Gene name	C-type lectin domain family 12 member A
Gene symbol	CLEC12A
Synonyms (NCBI Gene)	CD371CLL-1CLL1DCAL-2MICLhKLRL1
Chromosome	12
Chromosome location	12p13.31-p13.2
Summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT550172	hsa-miR-8485	HITS-CLIP	21572407
MIRT550173	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT550171	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT550170	hsa-miR-603	HITS-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707162	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT707161	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT707160	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT550167	hsa-miR-3941	HITS-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550172	hsa-miR-8485	PAR-CLIP	21572407
MIRT550173	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT550171	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT550170	hsa-miR-603	PAR-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550167	hsa-miR-3941	PAR-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT550172	hsa-miR-8485	HITS-CLIP	21572407
MIRT550173	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT550171	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT550170	hsa-miR-603	HITS-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707162	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT707161	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT707160	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT550167	hsa-miR-3941	HITS-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550172	hsa-miR-8485	PAR-CLIP	21572407
MIRT550173	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT550171	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT550170	hsa-miR-603	PAR-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550167	hsa-miR-3941	PAR-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT895605	hsa-miR-127-5p	CLIP-seq
MIRT895606	hsa-miR-128	CLIP-seq
MIRT895607	hsa-miR-27a	CLIP-seq
MIRT895608	hsa-miR-27b	CLIP-seq
MIRT895609	hsa-miR-3119	CLIP-seq
MIRT895610	hsa-miR-3921	CLIP-seq
MIRT895611	hsa-miR-4653-5p	CLIP-seq
MIRT895612	hsa-miR-4768-5p	CLIP-seq
MIRT895613	hsa-miR-513a-5p	CLIP-seq
MIRT2201502	hsa-miR-4640-3p	CLIP-seq
MIRT2201503	hsa-miR-483-3p	CLIP-seq
MIRT2504454	hsa-miR-3121-5p	CLIP-seq
MIRT2504454	hsa-miR-3121-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002283	Process	Neutrophil activation involved in immune response	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	38367667, 38386511, 39143217
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IMP	15238421
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14739280, 15238421, 16239426, 34234773, 38367667
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030545	Function	Signaling receptor regulator activity	IEA
GO:0032481	Process	Positive regulation of type I interferon production	ISS
GO:0032815	Process	Negative regulation of natural killer cell activation	IEA
GO:0032815	Process	Negative regulation of natural killer cell activation	IMP	15238421, 31269448
GO:0035579	Component	Specific granule membrane	TAS
GO:0038187	Function	Pattern recognition receptor activity	IDA	36542980
GO:0038187	Function	Pattern recognition receptor activity	IEA
GO:0038187	Function	Pattern recognition receptor activity	IMP	31269448
GO:0050728	Process	Negative regulation of inflammatory response	ISS
GO:0050777	Process	Negative regulation of immune response	IDA	14739280
GO:0070821	Component	Tertiary granule membrane	TAS
GO:1902564	Process	Negative regulation of neutrophil activation	IDA	34234773
GO:1902564	Process	Negative regulation of neutrophil activation	IEA
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IDA	16239426
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IEA

MIM	HGNC	e!Ensembl
612088	31713	ENSG00000172322

Q5QGZ9

Protein name

C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)

Protein function

Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217). Myeloid cell inhibiti

PDB

8JAH , 8W8T , 8W9J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00059	Lectin_C	150 → 250	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Preferentially expressed in lymphoid tissues and immune cells, including natural killer (NK) cells, T-cells, dendritic cells and monocytes or macrophages (PubMed:14739280, PubMed:15238421, PubMed:15548716, PubMed:16239426, PubMed:16838

Sequence

MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVL
ASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRE
LYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFI
KSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHC
TYKKRMICEKMANPVQLGSTYFREA

Sequence length

265

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ARTHRITIS, RHEUMATOID	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Arthritis	Associate	34045571, 34638548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Associate	34045571, 38302188	★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Associate	37102643	★★★★★ ★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	36928077	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Associate	34555062	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis	Associate	38302188	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gout	Associate	34638548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Autoinflammatory Diseases	Inhibit	34638548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Inhibit	26890122, 34045571, 34638548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	34045571, 37102643	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	30467201, 34053123, 36050244, 37818740	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Biphenotypic Acute	Associate	37818740	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	34830054	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	28810819, 29720577, 29946192, 33094319, 33495835, 33778076, 34053123, 36050244, 39582863	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia T Cell	Associate	27612176, 29411522, 30520015	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukocyte adhesion deficiency type 1	Associate	33495835	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases Interstitial	Associate	38302188	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Associate	35672358	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	36353633	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Myeloproliferative Diseases	Associate	33369070	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Associate	27612176, 29799854, 33369070, 34053123	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	27612176, 29411522, 36353633	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	29578204	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	38215390	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	27612176, 30520015	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Associate	36655999	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Associate	38302188	★★★★★ ★☆☆☆☆ Found in Text Mining only

CLEC12A (C-type lectin domain family 12 member A)