Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	158135
Gene name	Tubulin tyrosine ligase like 11
Gene symbol	TTLL11
Synonyms (NCBI Gene)	C9orf148C9orf20TTLL11-IT1bA244O19.1
Chromosome	9
Chromosome location	9q33.2

Show/Hide all (84)

miRTarBase ID	miRNA	Experiments	Reference
MIRT722142	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT722141	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT722140	hsa-miR-6072	HITS-CLIP	19536157
MIRT722139	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT722138	hsa-miR-3183	HITS-CLIP	19536157
MIRT722137	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT722136	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT722135	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT722134	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT722133	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT722132	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT722131	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT722130	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT722129	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT722128	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT722127	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT544123	hsa-miR-548a-3p	PAR-CLIP	20371350
MIRT544122	hsa-miR-548ar-3p	PAR-CLIP	20371350
MIRT544121	hsa-miR-548az-3p	PAR-CLIP	20371350
MIRT544120	hsa-miR-548e-3p	PAR-CLIP	20371350
MIRT544119	hsa-miR-548f-3p	PAR-CLIP	20371350
MIRT544118	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT544117	hsa-miR-4495	PAR-CLIP	20371350
MIRT544116	hsa-miR-6728-3p	PAR-CLIP	20371350
MIRT544123	hsa-miR-548a-3p	PAR-CLIP	21572407
MIRT544122	hsa-miR-548ar-3p	PAR-CLIP	21572407
MIRT544121	hsa-miR-548az-3p	PAR-CLIP	21572407
MIRT544120	hsa-miR-548e-3p	PAR-CLIP	21572407
MIRT544119	hsa-miR-548f-3p	PAR-CLIP	21572407
MIRT544118	hsa-miR-5582-3p	PAR-CLIP	21572407
MIRT544117	hsa-miR-4495	PAR-CLIP	21572407
MIRT544116	hsa-miR-6728-3p	PAR-CLIP	21572407
MIRT722142	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT722141	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT722140	hsa-miR-6072	HITS-CLIP	19536157
MIRT722139	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT722138	hsa-miR-3183	HITS-CLIP	19536157
MIRT722137	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT722136	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT722135	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT722134	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT722133	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT722132	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT722131	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT722130	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT722129	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT722128	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT722127	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT544123	hsa-miR-548a-3p	PAR-CLIP	20371350
MIRT544122	hsa-miR-548ar-3p	PAR-CLIP	20371350
MIRT544121	hsa-miR-548az-3p	PAR-CLIP	20371350
MIRT544120	hsa-miR-548e-3p	PAR-CLIP	20371350
MIRT544119	hsa-miR-548f-3p	PAR-CLIP	20371350
MIRT544118	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT544117	hsa-miR-4495	PAR-CLIP	20371350
MIRT544116	hsa-miR-6728-3p	PAR-CLIP	20371350
MIRT544123	hsa-miR-548a-3p	PAR-CLIP	21572407
MIRT544122	hsa-miR-548ar-3p	PAR-CLIP	21572407
MIRT544121	hsa-miR-548az-3p	PAR-CLIP	21572407
MIRT544120	hsa-miR-548e-3p	PAR-CLIP	21572407
MIRT544119	hsa-miR-548f-3p	PAR-CLIP	21572407
MIRT544118	hsa-miR-5582-3p	PAR-CLIP	21572407
MIRT544117	hsa-miR-4495	PAR-CLIP	21572407
MIRT544116	hsa-miR-6728-3p	PAR-CLIP	21572407
MIRT1462329	hsa-miR-29a	CLIP-seq
MIRT1462330	hsa-miR-29b	CLIP-seq
MIRT1462331	hsa-miR-29c	CLIP-seq
MIRT1462332	hsa-miR-3065-3p	CLIP-seq
MIRT1462333	hsa-miR-3189-5p	CLIP-seq
MIRT1462334	hsa-miR-377	CLIP-seq
MIRT1462335	hsa-miR-4270	CLIP-seq
MIRT1462336	hsa-miR-4441	CLIP-seq
MIRT1462337	hsa-miR-4453	CLIP-seq
MIRT1462338	hsa-miR-4538	CLIP-seq
MIRT1462339	hsa-miR-4758-3p	CLIP-seq
MIRT1462329	hsa-miR-29a	CLIP-seq
MIRT1462330	hsa-miR-29b	CLIP-seq
MIRT1462331	hsa-miR-29c	CLIP-seq
MIRT1462332	hsa-miR-3065-3p	CLIP-seq
MIRT1462334	hsa-miR-377	CLIP-seq
MIRT1462335	hsa-miR-4270	CLIP-seq
MIRT1462336	hsa-miR-4441	CLIP-seq
MIRT1462337	hsa-miR-4453	CLIP-seq
MIRT1462338	hsa-miR-4538	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IEA
GO:0015631	Function	Tubulin binding	IBA
GO:0016874	Function	Ligase activity	IEA
GO:0036064	Component	Ciliary basal body	IBA
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051013	Process	Microtubule severing	IEA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IEA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	ISS
GO:0070740	Function	Tubulin-glutamic acid ligase activity	TAS
GO:0106437	Function	Protein-glutamic acid ligase activity, initiating	IEA
GO:0106438	Function	Protein-glutamic acid ligase activity, elongating	IEA

MIM	HGNC	e!Ensembl
620694	18113	ENSG00000175764

Q8NHH1

Protein name

Tubulin polyglutamylase TTLL11 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 11)

Protein function

Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03133	TTL	263 → 572	Tubulin-tyrosine ligase family	Family

Sequence

MAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAAVNPSLSDHGNGLGRGTRGSG
CSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEA
EATAETVAEQVRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPP
SKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSKARTSLDALKISIRQL
KWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPGMTEMVRKITLSRAVRTMQNLFPE
EYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRL
AGTLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEP
TPKNLHRIFMHLTNYSLNIHSGNFIHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDII
SVVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPILLEVNANPSMRI
EHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLMDPLKKKRENQSQQLEKPFAGKEDALD
GELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGP
TGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQR
KFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGVPSGGRPPHRGPPQEPSPSAQPAGD
NPPPRTSCANKLSHPRHTLS

Sequence length

800

Interactions

View interactions

	Reactome
			Carboxyterminal post-translational modifications of tubulin

TTLL11 (tubulin tyrosine ligase like 11)