PEBP4 (phosphatidylethanolamine binding protein 4)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
157310
Gene name Gene Name - the full gene name approved by the HGNC.
Phosphatidylethanolamine binding protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PEBP4
Synonyms (NCBI Gene) Gene synonyms aliases
CORK-1, CORK1, GWTM1933, HEL-S-300, PEBP-4, PRO4408, hPEBP4
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.3
Summary Summary of gene provided in NCBI Entrez Gene.
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[suppli
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT017934 hsa-miR-335-5p Microarray 18185580
MIRT1224531 hsa-miR-3148 CLIP-seq
MIRT1224532 hsa-miR-3978 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19197339
GO:0005576 Component Extracellular region IEA
GO:0070062 Component Extracellular exosome HDA 23533145
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
612473 28319 ENSG00000134020
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q96S96
Protein name Phosphatidylethanolamine-binding protein 4 (PEBP-4) (hPEBP4) (Protein cousin-of-RKIP 1)
Protein function Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01161 PBP 63 → 200 Phosphatidylethanolamine-binding protein Domain
Sequence
Sequence length 227
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Bipolar Disorder Bipolar disorder N/A N/A GWAS
Carcinoma Basal cell carcinoma N/A N/A GWAS
Show/Hide Text Mining Associations (19)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 15302887, 17178731, 20460377
Carcinoma Endometrioid Associate 23818363
Carcinoma Hepatocellular Associate 35955931
Carcinoma Non Small Cell Lung Associate 22076923, 22983920
Carcinoma Squamous Cell Associate 21887552
Colorectal Neoplasms Associate 22125029
Drug Related Side Effects and Adverse Reactions Associate 25038915
Endometrial Neoplasms Associate 23818363
Idiopathic Pulmonary Fibrosis Associate 39289672
Lung Neoplasms Associate 22983920, 25038915