RAET1L (retinoic acid early transcript 1L)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
154064
Gene name Gene Name - the full gene name approved by the HGNC.
Retinoic acid early transcript 1L
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAET1L
Synonyms (NCBI Gene) Gene synonyms aliases
RAET1H, ULBP6
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 d
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(112)
miRTarBase ID miRNA Experiments Reference
MIRT492514 hsa-miR-29a-3p PAR-CLIP 23592263
MIRT492513 hsa-miR-29b-3p PAR-CLIP 23592263
MIRT492512 hsa-miR-29c-3p PAR-CLIP 23592263
MIRT492511 hsa-miR-6871-3p PAR-CLIP 23592263
MIRT492509 hsa-miR-6884-3p PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0001916 Process Positive regulation of T cell mediated cytotoxicity IBA
GO:0002376 Process Immune system process IEA
GO:0002476 Process Antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
GO:0002486 Process Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
GO:0005515 Function Protein binding IPI 19658097, 28559451, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
611047 16798 ENSG00000155918
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q5VY80
Protein name UL16-binding protein 6 (Retinoic acid early transcript 1L protein)
Protein function Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
PDB 4S0U , 8RWB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00129 MHC_I 29 → 205 Class I Histocompatibility antigen, domains alpha 1 and 2 Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed (PubMed:11827464). Expressed in trachea (PubMed:19658097). Constitutively expressed in peripheral blood mononuclear cells, including B-cells and natural killer cells, as well as CD4+ and CD8+ T-cells and monocytes. Ten
Sequence
Sequence length 246
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Natural killer cell mediated cytotoxicity   Post-translational modification: synthesis of GPI-anchored proteins
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Carcinoma Basal cell carcinoma N/A N/A GWAS
Show/Hide Text Mining Associations (11)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Cholangiocarcinoma Associate 26608587
Colonic Neoplasms Associate 33909599
Crohn Disease Associate 28684217
Inflammation Associate 22479353
Lens Subluxation Associate 22479353
Leukemia Myeloid Acute Associate 35003895
Lymphoma Non Hodgkin Associate 33779082
Marfan Syndrome Associate 22479353
Precursor T Cell Lymphoblastic Leukemia Lymphoma Associate 33168453
Uterine Cervical Neoplasms Associate 19658097