Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1540
Gene name Gene Name - the full gene name approved by the HGNC.	CYLD lysine 63 deubiquitinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CYLD
Synonyms (NCBI Gene) Gene synonyms aliases	BRSS, CDMT, CYLD1, CYLDI, EAC, FTDALS8, MFT, MFT1, SBS, TEM, USPL2
Disease Acronyms (UniProt) Disease acronyms from UniProt database	BRSS, FTDALS8, MFT1
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial tric

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SNP ID	Visualize variation	Clinical significance	Consequence
rs764952788	C>A,T	Pathogenic	Missense variant, coding sequence variant, stop gained, non coding transcript variant
rs886040868	TGGA>-	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs886040869	->C	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs886040870	CAAGAGGTGT>-	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs886040871	->AG	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs886040872	C>A	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs886040873	C>T	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs886040874	->T	Pathogenic	Frameshift variant, non coding transcript variant, intron variant, coding sequence variant
rs886040875	->T	Pathogenic	Frameshift variant, non coding transcript variant, intron variant, coding sequence variant
rs886040876	ATCA>-	Pathogenic	Frameshift variant, non coding transcript variant, intron variant, coding sequence variant
rs886040879	A>T	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1596971597	->T	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs1597052041	->T	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs1597055529	TT>-	Pathogenic	Intron variant, coding sequence variant, frameshift variant, non coding transcript variant
rs1597058708	T>G	Pathogenic	Splice donor variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004211	hsa-miR-197-3p	Microarray	16822819
MIRT005595	hsa-miR-181b-5p	Luciferase reporter assay, qRT-PCR	20797623
MIRT006978	hsa-miR-182-5p	Luciferase reporter assay, qRT-PCR, Western blot	23006329
MIRT006978	hsa-miR-182-5p	Luciferase reporter assay, qRT-PCR, Western blot	23006329
MIRT044462	hsa-miR-320a	CLASH	23622248
MIRT053602	hsa-miR-362-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24495516
MIRT053602	hsa-miR-362-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24495516
MIRT054270	hsa-miR-500a-5p	Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	25595906
MIRT054270	hsa-miR-500a-5p	Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	25595906
MIRT053602	hsa-miR-362-5p	Luciferase reporter assay	25449782
MIRT543282	hsa-miR-8485	HITS-CLIP	21572407
MIRT543281	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT543280	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT543279	hsa-miR-603	HITS-CLIP	21572407
MIRT543278	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT543277	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT543276	hsa-miR-3941	HITS-CLIP	21572407
MIRT543275	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT668823	hsa-miR-1321	HITS-CLIP	23824327
MIRT668824	hsa-miR-4739	HITS-CLIP	23824327
MIRT668822	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT668821	hsa-miR-211-3p	HITS-CLIP	23824327
MIRT668820	hsa-miR-4270	HITS-CLIP	23824327
MIRT668819	hsa-miR-4441	HITS-CLIP	23824327
MIRT668818	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT668817	hsa-miR-4528	HITS-CLIP	23824327
MIRT668816	hsa-miR-4301	HITS-CLIP	23824327
MIRT668815	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT668814	hsa-miR-4751	HITS-CLIP	23824327
MIRT668813	hsa-miR-659-5p	HITS-CLIP	23824327
MIRT668812	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT668811	hsa-miR-765	HITS-CLIP	23824327
MIRT668810	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT668809	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT668808	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT668807	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT640133	hsa-miR-1245b-5p	HITS-CLIP	23824327
MIRT640131	hsa-miR-3142	HITS-CLIP	23824327
MIRT640132	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT640130	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT640129	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT640128	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT640127	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT640126	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT640125	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT640124	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT640122	hsa-miR-7975	HITS-CLIP	23824327
MIRT640123	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT640121	hsa-miR-1200	HITS-CLIP	23824327
MIRT640120	hsa-miR-3685	HITS-CLIP	23824327
MIRT640119	hsa-miR-384	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT543282	hsa-miR-8485	PAR-CLIP	21572407
MIRT543281	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT543280	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT543279	hsa-miR-603	PAR-CLIP	21572407
MIRT543278	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT543277	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT543276	hsa-miR-3941	PAR-CLIP	21572407
MIRT543275	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT074792	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT074789	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT074792	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727910	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727909	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727908	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727907	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT074788	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT074795	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT074790	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT074799	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT074789	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT053602	hsa-miR-362-5p	Luciferase reporter assay	26893711
MIRT732122	hsa-miR-130b-3p	Luciferase reporter assay, qRT-PCR, Western blot	26711782
MIRT732122	hsa-miR-130b-3p	Luciferase reporter assay, qRT-PCR, Western blot	26711782
MIRT005595	hsa-miR-181b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27189061
MIRT005595	hsa-miR-181b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27189061
MIRT005595	hsa-miR-181b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27189061
MIRT005595	hsa-miR-181b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27189061
MIRT005595	hsa-miR-181b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27189061
MIRT005595	hsa-miR-181b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27189061
MIRT053602	hsa-miR-362-5p	Luciferase reporter assay	25909817
MIRT053602	hsa-miR-362-5p	Luciferase reporter assay	25909817
MIRT613451	hsa-miR-605-5p	HITS-CLIP	27418678
MIRT733100	hsa-miR-135b-5p	Immunofluorescence, Immunohistochemistry (IHC), In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blotting	33990540
MIRT543282	hsa-miR-8485	HITS-CLIP	21572407
MIRT543281	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT543280	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT543279	hsa-miR-603	HITS-CLIP	21572407
MIRT543278	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT543277	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT543276	hsa-miR-3941	HITS-CLIP	21572407
MIRT543275	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT668823	hsa-miR-1321	HITS-CLIP	23824327
MIRT668824	hsa-miR-4739	HITS-CLIP	23824327
MIRT668822	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT668821	hsa-miR-211-3p	HITS-CLIP	23824327
MIRT668820	hsa-miR-4270	HITS-CLIP	23824327
MIRT668819	hsa-miR-4441	HITS-CLIP	23824327
MIRT668818	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT668817	hsa-miR-4528	HITS-CLIP	23824327
MIRT668816	hsa-miR-4301	HITS-CLIP	23824327
MIRT668815	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT668814	hsa-miR-4751	HITS-CLIP	23824327
MIRT668813	hsa-miR-659-5p	HITS-CLIP	23824327
MIRT668812	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT668811	hsa-miR-765	HITS-CLIP	23824327
MIRT668810	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT668809	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT668808	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT668807	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT640133	hsa-miR-1245b-5p	HITS-CLIP	23824327
MIRT640131	hsa-miR-3142	HITS-CLIP	23824327
MIRT640132	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT640130	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT640129	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT640128	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT640127	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT640126	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT640125	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT640124	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT640122	hsa-miR-7975	HITS-CLIP	23824327
MIRT640123	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT640121	hsa-miR-1200	HITS-CLIP	23824327
MIRT640120	hsa-miR-3685	HITS-CLIP	23824327
MIRT640119	hsa-miR-384	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT613451	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613176	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613175	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT613174	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613173	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT613172	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT613171	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613170	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613169	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT543282	hsa-miR-8485	PAR-CLIP	21572407
MIRT543281	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT543280	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT543279	hsa-miR-603	PAR-CLIP	21572407
MIRT543278	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT543277	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT543276	hsa-miR-3941	PAR-CLIP	21572407
MIRT543275	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT920248	hsa-miR-1298	CLIP-seq
MIRT920249	hsa-miR-1302	CLIP-seq
MIRT920250	hsa-miR-15a	CLIP-seq
MIRT920251	hsa-miR-15b	CLIP-seq
MIRT920252	hsa-miR-16	CLIP-seq
MIRT920253	hsa-miR-1912	CLIP-seq
MIRT920254	hsa-miR-195	CLIP-seq
MIRT920255	hsa-miR-19a	CLIP-seq
MIRT920256	hsa-miR-19b	CLIP-seq
MIRT920257	hsa-miR-3124-3p	CLIP-seq
MIRT920258	hsa-miR-3126-5p	CLIP-seq
MIRT920259	hsa-miR-3163	CLIP-seq
MIRT920260	hsa-miR-320b	CLIP-seq
MIRT920261	hsa-miR-320c	CLIP-seq
MIRT920262	hsa-miR-320d	CLIP-seq
MIRT920263	hsa-miR-3660	CLIP-seq
MIRT920264	hsa-miR-3692	CLIP-seq
MIRT920265	hsa-miR-424	CLIP-seq
MIRT920266	hsa-miR-4298	CLIP-seq
MIRT920267	hsa-miR-4419a	CLIP-seq
MIRT920268	hsa-miR-4429	CLIP-seq
MIRT920269	hsa-miR-4510	CLIP-seq
MIRT920270	hsa-miR-4526	CLIP-seq
MIRT920271	hsa-miR-4645-3p	CLIP-seq
MIRT920272	hsa-miR-4797-5p	CLIP-seq
MIRT920273	hsa-miR-497	CLIP-seq
MIRT920274	hsa-miR-542-3p	CLIP-seq
MIRT920275	hsa-miR-548aa	CLIP-seq
MIRT920276	hsa-miR-3160-3p	CLIP-seq
MIRT920277	hsa-miR-4709-5p	CLIP-seq
MIRT920272	hsa-miR-4797-5p	CLIP-seq
MIRT920274	hsa-miR-542-3p	CLIP-seq
MIRT920278	hsa-miR-802	CLIP-seq
MIRT920279	hsa-miR-105	CLIP-seq
MIRT920280	hsa-miR-1207-5p	CLIP-seq
MIRT920281	hsa-miR-1273f	CLIP-seq
MIRT920282	hsa-miR-1273g	CLIP-seq
MIRT920283	hsa-miR-129-3p	CLIP-seq
MIRT920248	hsa-miR-1298	CLIP-seq
MIRT920284	hsa-miR-130a	CLIP-seq
MIRT920285	hsa-miR-130b	CLIP-seq
MIRT920286	hsa-miR-139-5p	CLIP-seq
MIRT920250	hsa-miR-15a	CLIP-seq
MIRT920251	hsa-miR-15b	CLIP-seq
MIRT920252	hsa-miR-16	CLIP-seq
MIRT920287	hsa-miR-1827	CLIP-seq
MIRT920254	hsa-miR-195	CLIP-seq
MIRT920288	hsa-miR-197	CLIP-seq
MIRT920255	hsa-miR-19a	CLIP-seq
MIRT920256	hsa-miR-19b	CLIP-seq
MIRT920289	hsa-miR-2054	CLIP-seq
MIRT920290	hsa-miR-2277-3p	CLIP-seq
MIRT920291	hsa-miR-23a	CLIP-seq
MIRT920292	hsa-miR-23b	CLIP-seq
MIRT920293	hsa-miR-23c	CLIP-seq
MIRT920294	hsa-miR-301a	CLIP-seq
MIRT920295	hsa-miR-301b	CLIP-seq
MIRT920257	hsa-miR-3124-3p	CLIP-seq
MIRT920296	hsa-miR-3132	CLIP-seq
MIRT920297	hsa-miR-3143	CLIP-seq
MIRT920298	hsa-miR-3149	CLIP-seq
MIRT920299	hsa-miR-3173-3p	CLIP-seq
MIRT920260	hsa-miR-320b	CLIP-seq
MIRT920261	hsa-miR-320c	CLIP-seq
MIRT920262	hsa-miR-320d	CLIP-seq
MIRT920300	hsa-miR-3612	CLIP-seq
MIRT920301	hsa-miR-3617	CLIP-seq
MIRT920302	hsa-miR-3655	CLIP-seq
MIRT920303	hsa-miR-3666	CLIP-seq
MIRT920264	hsa-miR-3692	CLIP-seq
MIRT920304	hsa-miR-369-3p	CLIP-seq
MIRT920305	hsa-miR-374a	CLIP-seq
MIRT920306	hsa-miR-374b	CLIP-seq
MIRT920307	hsa-miR-421	CLIP-seq
MIRT920265	hsa-miR-424	CLIP-seq
MIRT920308	hsa-miR-4263	CLIP-seq
MIRT920309	hsa-miR-4272	CLIP-seq
MIRT920310	hsa-miR-4295	CLIP-seq
MIRT920311	hsa-miR-4305	CLIP-seq
MIRT920312	hsa-miR-4325	CLIP-seq
MIRT920313	hsa-miR-4428	CLIP-seq
MIRT920268	hsa-miR-4429	CLIP-seq
MIRT920314	hsa-miR-4443	CLIP-seq
MIRT920315	hsa-miR-4446-5p	CLIP-seq
MIRT920316	hsa-miR-4477a	CLIP-seq
MIRT920317	hsa-miR-4521	CLIP-seq
MIRT920318	hsa-miR-4534	CLIP-seq
MIRT920319	hsa-miR-454	CLIP-seq
MIRT920320	hsa-miR-4666-5p	CLIP-seq
MIRT920321	hsa-miR-4668-3p	CLIP-seq
MIRT920322	hsa-miR-4678	CLIP-seq
MIRT920323	hsa-miR-4687-5p	CLIP-seq
MIRT920324	hsa-miR-4698	CLIP-seq
MIRT920325	hsa-miR-4700-3p	CLIP-seq
MIRT920326	hsa-miR-4763-3p	CLIP-seq
MIRT920327	hsa-miR-4775	CLIP-seq
MIRT920328	hsa-miR-4777-5p	CLIP-seq
MIRT920329	hsa-miR-4789-3p	CLIP-seq
MIRT920272	hsa-miR-4797-5p	CLIP-seq
MIRT920330	hsa-miR-4802-5p	CLIP-seq
MIRT920331	hsa-miR-4803	CLIP-seq
MIRT920332	hsa-miR-487a	CLIP-seq
MIRT920333	hsa-miR-490-3p	CLIP-seq
MIRT920273	hsa-miR-497	CLIP-seq
MIRT920334	hsa-miR-500a	CLIP-seq
MIRT920335	hsa-miR-518d-5p	CLIP-seq
MIRT920336	hsa-miR-519b-5p	CLIP-seq
MIRT920337	hsa-miR-519c-5p	CLIP-seq
MIRT920338	hsa-miR-520c-5p	CLIP-seq
MIRT920339	hsa-miR-526a	CLIP-seq
MIRT920340	hsa-miR-526b	CLIP-seq
MIRT920274	hsa-miR-542-3p	CLIP-seq
MIRT920341	hsa-miR-543	CLIP-seq
MIRT920342	hsa-miR-556-3p	CLIP-seq
MIRT920343	hsa-miR-579	CLIP-seq
MIRT920344	hsa-miR-641	CLIP-seq
MIRT920345	hsa-miR-649	CLIP-seq
MIRT920346	hsa-miR-650	CLIP-seq
MIRT920347	hsa-miR-661	CLIP-seq
MIRT920348	hsa-miR-940	CLIP-seq
MIRT920349	hsa-miR-944	CLIP-seq
MIRT738335	hsa-miR-1283	CLIP-seq
MIRT738336	hsa-miR-3618	CLIP-seq
MIRT738338	hsa-miR-4264	CLIP-seq
MIRT738340	hsa-miR-4691-5p	CLIP-seq
MIRT738339	hsa-miR-4797-3p	CLIP-seq
MIRT738337	hsa-miR-622	CLIP-seq
MIRT1972722	hsa-miR-1289	CLIP-seq
MIRT1972723	hsa-miR-1909	CLIP-seq
MIRT920253	hsa-miR-1912	CLIP-seq
MIRT920289	hsa-miR-2054	CLIP-seq
MIRT1972724	hsa-miR-3121-3p	CLIP-seq
MIRT920257	hsa-miR-3124-3p	CLIP-seq
MIRT1972725	hsa-miR-3130-5p	CLIP-seq
MIRT920259	hsa-miR-3163	CLIP-seq
MIRT1972726	hsa-miR-3198	CLIP-seq
MIRT1972727	hsa-miR-331-3p	CLIP-seq
MIRT1972728	hsa-miR-340	CLIP-seq
MIRT1972729	hsa-miR-3591-3p	CLIP-seq
MIRT1972730	hsa-miR-3646	CLIP-seq
MIRT1972731	hsa-miR-3647-3p	CLIP-seq
MIRT920264	hsa-miR-3692	CLIP-seq
MIRT1972732	hsa-miR-3942-3p	CLIP-seq
MIRT1972733	hsa-miR-4261	CLIP-seq
MIRT1972734	hsa-miR-4292	CLIP-seq
MIRT1972735	hsa-miR-4294	CLIP-seq
MIRT1972736	hsa-miR-4309	CLIP-seq
MIRT920267	hsa-miR-4419a	CLIP-seq
MIRT1972737	hsa-miR-4436a	CLIP-seq
MIRT1972738	hsa-miR-4482	CLIP-seq
MIRT1972739	hsa-miR-4496	CLIP-seq
MIRT920269	hsa-miR-4510	CLIP-seq
MIRT920318	hsa-miR-4534	CLIP-seq
MIRT1972740	hsa-miR-4646-5p	CLIP-seq
MIRT1972741	hsa-miR-4659a-3p	CLIP-seq
MIRT1972742	hsa-miR-4659b-3p	CLIP-seq
MIRT1972743	hsa-miR-4699-3p	CLIP-seq
MIRT1972744	hsa-miR-4713-5p	CLIP-seq
MIRT1972745	hsa-miR-4729	CLIP-seq
MIRT1972746	hsa-miR-4747-5p	CLIP-seq
MIRT1972747	hsa-miR-495	CLIP-seq
MIRT1972748	hsa-miR-532-3p	CLIP-seq
MIRT1972749	hsa-miR-587	CLIP-seq
MIRT1972750	hsa-miR-601	CLIP-seq
MIRT1972751	hsa-miR-665	CLIP-seq
MIRT1972752	hsa-miR-3675-3p	CLIP-seq
MIRT920316	hsa-miR-4477a	CLIP-seq
MIRT920343	hsa-miR-579	CLIP-seq
MIRT2208416	hsa-miR-583	CLIP-seq
MIRT920255	hsa-miR-19a	CLIP-seq
MIRT920256	hsa-miR-19b	CLIP-seq
MIRT2208417	hsa-miR-34b	CLIP-seq
MIRT2208418	hsa-miR-371-5p	CLIP-seq
MIRT2208419	hsa-miR-371b-5p	CLIP-seq
MIRT920324	hsa-miR-4698	CLIP-seq
MIRT1972745	hsa-miR-4729	CLIP-seq
MIRT2208420	hsa-miR-513c	CLIP-seq
MIRT2208421	hsa-miR-514b-5p	CLIP-seq
MIRT2208422	hsa-miR-516a-3p	CLIP-seq
MIRT920275	hsa-miR-548aa	CLIP-seq
MIRT920343	hsa-miR-579	CLIP-seq
MIRT1972745	hsa-miR-4729	CLIP-seq
MIRT920343	hsa-miR-579	CLIP-seq
MIRT2512258	hsa-miR-1	CLIP-seq
MIRT2512259	hsa-miR-1202	CLIP-seq
MIRT2512260	hsa-miR-1258	CLIP-seq
MIRT738335	hsa-miR-1283	CLIP-seq
MIRT2512261	hsa-miR-135a	CLIP-seq
MIRT2512262	hsa-miR-135b	CLIP-seq
MIRT2512263	hsa-miR-206	CLIP-seq
MIRT2512264	hsa-miR-3117-3p	CLIP-seq
MIRT2512265	hsa-miR-3152-5p	CLIP-seq
MIRT2512266	hsa-miR-3168	CLIP-seq
MIRT2512267	hsa-miR-3169	CLIP-seq
MIRT2512268	hsa-miR-3194-5p	CLIP-seq
MIRT738336	hsa-miR-3618	CLIP-seq
MIRT2512269	hsa-miR-3620	CLIP-seq
MIRT920302	hsa-miR-3655	CLIP-seq
MIRT2512270	hsa-miR-3663-5p	CLIP-seq
MIRT2512271	hsa-miR-3673	CLIP-seq
MIRT2512272	hsa-miR-3972	CLIP-seq
MIRT2512273	hsa-miR-4267	CLIP-seq
MIRT2512274	hsa-miR-4297	CLIP-seq
MIRT920311	hsa-miR-4305	CLIP-seq
MIRT2512275	hsa-miR-4328	CLIP-seq
MIRT2512276	hsa-miR-4426	CLIP-seq
MIRT2512277	hsa-miR-4522	CLIP-seq
MIRT2512278	hsa-miR-4647	CLIP-seq
MIRT2512279	hsa-miR-4662b	CLIP-seq
MIRT2512280	hsa-miR-4687-3p	CLIP-seq
MIRT2512281	hsa-miR-4694-3p	CLIP-seq
MIRT920324	hsa-miR-4698	CLIP-seq
MIRT2512282	hsa-miR-4759	CLIP-seq
MIRT2512283	hsa-miR-4766-3p	CLIP-seq
MIRT2512284	hsa-miR-4774-3p	CLIP-seq
MIRT920328	hsa-miR-4777-5p	CLIP-seq
MIRT920335	hsa-miR-518d-5p	CLIP-seq
MIRT920336	hsa-miR-519b-5p	CLIP-seq
MIRT920337	hsa-miR-519c-5p	CLIP-seq
MIRT920338	hsa-miR-520c-5p	CLIP-seq
MIRT920339	hsa-miR-526a	CLIP-seq
MIRT2512285	hsa-miR-548p	CLIP-seq
MIRT1972750	hsa-miR-601	CLIP-seq
MIRT2512286	hsa-miR-613	CLIP-seq
MIRT2512287	hsa-miR-891a	CLIP-seq
MIRT738335	hsa-miR-1283	CLIP-seq
MIRT2512261	hsa-miR-135a	CLIP-seq
MIRT2512262	hsa-miR-135b	CLIP-seq
MIRT1972723	hsa-miR-1909	CLIP-seq
MIRT2678955	hsa-miR-298	CLIP-seq
MIRT2678956	hsa-miR-3074-5p	CLIP-seq
MIRT738336	hsa-miR-3618	CLIP-seq
MIRT2512269	hsa-miR-3620	CLIP-seq
MIRT2512270	hsa-miR-3663-5p	CLIP-seq
MIRT2678957	hsa-miR-3665	CLIP-seq
MIRT2678958	hsa-miR-370	CLIP-seq
MIRT920316	hsa-miR-4477a	CLIP-seq
MIRT2678959	hsa-miR-4533	CLIP-seq
MIRT2512280	hsa-miR-4687-3p	CLIP-seq
MIRT1972746	hsa-miR-4747-5p	CLIP-seq
MIRT1972747	hsa-miR-495	CLIP-seq
MIRT2678960	hsa-miR-552	CLIP-seq
MIRT1972750	hsa-miR-601	CLIP-seq
MIRT2678961	hsa-miR-657	CLIP-seq
MIRT2678962	hsa-miR-764	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
LEF1	Repression	22157808
LEF1	Unknown	24577083

Show/Hide all(52)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IBA	21873635
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IDA	18313383, 18636086, 27458237, 27591049
GO:0005515	Function	Protein binding	IPI	18636086, 19615732, 19893491, 20227366, 22057290, 24981860, 25134987, 26997266, 27307491, 27458237, 27545878, 27591049
GO:0005813	Component	Centrosome	IDA	25134987
GO:0005819	Component	Spindle	IDA	25134987
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	18313383
GO:0005829	Component	Cytosol	TAS
GO:0005881	Component	Cytoplasmic microtubule	IDA	17495026
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0007346	Process	Regulation of mitotic cell cycle	IBA	21873635
GO:0007346	Process	Regulation of mitotic cell cycle	IMP	17495026
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IDA	18313383
GO:0010803	Process	Regulation of tumor necrosis factor-mediated signaling pathway	IDA	26997266, 27458237, 27591049
GO:0010803	Process	Regulation of tumor necrosis factor-mediated signaling pathway	TAS
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016579	Process	Protein deubiquitination	IDA	29291351
GO:0016579	Process	Protein deubiquitination	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0019901	Function	Protein kinase binding	IPI	17495026, 18636086
GO:0030496	Component	Midbody	IDA	17495026
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IDA	20194890
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IBA	21873635
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	18313383
GO:0032480	Process	Negative regulation of type I interferon production	TAS
GO:0036064	Component	Ciliary basal body	ISS
GO:0045087	Process	Innate immune response	IDA	26997266
GO:0046329	Process	Negative regulation of JNK cascade	IDA	29291351
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050727	Process	Regulation of inflammatory response	IDA	27591049
GO:0060544	Process	Regulation of necroptotic process	IDA	27458237
GO:0061578	Function	Lys63-specific deubiquitinase activity	IBA	21873635
GO:0061578	Function	Lys63-specific deubiquitinase activity	IDA	18313383, 26997266, 29291351
GO:0061578	Function	Lys63-specific deubiquitinase activity	TAS
GO:0070064	Function	Proline-rich region binding	IPI	15341735
GO:0070266	Process	Necroptotic process	IBA	21873635
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IMP	20194890
GO:0070536	Process	Protein K63-linked deubiquitination	IBA	21873635
GO:0070536	Process	Protein K63-linked deubiquitination	IDA	18313383, 18636086, 26997266, 27458237, 27591049, 29291351
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	20227366
GO:0097542	Component	Ciliary tip	ISS
GO:1901223	Process	Negative regulation of NIK/NF-kappaB signaling	IDA	18313383
GO:1902017	Process	Regulation of cilium assembly	ISS
GO:1903753	Process	Negative regulation of p38MAPK cascade	IDA	29291351
GO:1990108	Process	Protein linear deubiquitination	IDA	26997266, 27458237, 27591049
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA	21873635
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IMP	21525013
GO:2001242	Process	Regulation of intrinsic apoptotic signaling pathway	IBA	21873635
GO:2001242	Process	Regulation of intrinsic apoptotic signaling pathway	IMP	21525013

MIM	HGNC	e!Ensembl
605018	2584	ENSG00000083799

Protein

UniProt ID

Q9NQC7

Protein name

Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)

Protein function

Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, Pub

PDB

1IXD , 1WHL , 1WHM , 2VHF , 7OWC , 7OWD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01302	CAP_GLY	127 → 202	CAP-Gly domain	Domain
PF16607	CYLD_phos_site	307 → 471		Disordered
PF01302	CAP_GLY	472 → 539	CAP-Gly domain	Domain
PF00443	UCH	592 → 894	Ubiquitin carboxyl-terminal hydrolase	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. {ECO:0000269|PubMed:10835629, ECO:000

Sequence

MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRI
PSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERFSLFKNRNRLS
KGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKV
GETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFACVESTILLHIN
DIIPALSESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTSDPGNRNRSELFYTLNG
SSVDSQPQSKSKNTWYIDEVAEDPAKSLTEISTDFDRSSPPLQPPPVNSLTTENRFHSLP
FSLTKMPNTNGSIGHSPLSLSAQSVMEELNTAPVQESPPLAMPPGNSHGLEVGSLAEVKE
NPPFYGVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCR
PDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNS
CYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIM
KLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFME
KNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDL
LEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSL
PKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNG
FNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK

Sequence length

956

Interactions

View interactions

	KEGG		Reactome
	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Brooke-spiegler syndrome	Brooke-Spiegler syndrome	rs121908388, rs1597088499, rs121908389, rs121908390, rs1597052041, rs886040870, rs886040874, rs886040875, rs886040884, rs886040885, rs886040888	12190880, 14632188, 17851586, 20227366, 16713561, 19807742, 12917690, 12950348, 17662085, 10835629, 18234730, 15854031, 16484982
Carcinoma	Carcinoma, Basal Cell	rs121912654, rs555607708, rs786202962, rs1564055259
Cervical cancer	cervical cancer	rs28934571, rs121913482, rs121913483	29477382
Cylindromatosis	Eccrine dermal cylindroma, Familial cylindromatosis	rs1597091470, rs121908388, rs1597088499, rs121908390, rs1596971597, rs2147483647, rs886040868, rs886040869, rs886040871, rs886040872, rs764952788, rs886040873, rs886040876, rs886040879, rs886040882 View all (8 more)	18234730
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355 View all (44 more)	17043644
Multiple trichoepithelioma	Familial multiple trichoepitheliomata, Familial multiple trichoepithelioma	rs1597085967, rs1597058708, rs121908389, rs121908390	16922728, 18234730, 19462465, 14632188, 16307661

Show/Hide Unknown Diseases (8)

Disease term	Disease name	References	Source
Unknown
Crohn disease	Crohn Disease	17804789	ClinVar
Head and neck cancer	Malignant Head and Neck Neoplasm		ClinVar
Epithelioma	trichoepithelioma, multiple familial, 1		GenCC
Amyotrophic Lateral Sclerosis	amyotrophic lateral sclerosis		GenCC
Crohn Disease	Crohn Disease		GWAS
Asthma	Asthma		GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease		GWAS
Leprosy	Leprosy		GWAS

Show/Hide Text Mining Associations (83)

Disease Name	Relationship Type	References
Associations from Text Mining
Acrospiroma	Associate	31101826
Adenocarcinoma	Associate	29463883
Adenocarcinoma of Lung	Associate	29286108, 31860169
Alzheimer Disease	Associate	36000313
Amyotrophic Lateral Sclerosis	Associate	36000313
Anus Neoplasms	Associate	32461623
Autoimmune Diseases	Associate	26276688
Bisphosphonate Associated Osteonecrosis of the Jaw	Associate	32705175
Carcinogenesis	Associate	12917690, 16900776, 17495026, 26276688
Carcinoma Adenoid Cystic	Associate	15854031, 16627981, 16900776, 17495026, 21552290, 23778141, 25951887, 26660106, 26969893, 29569226, 31101826, 32461623, 32892208
Carcinoma Basal Cell	Associate	32461623, 36309102
Carcinoma Endometrioid	Inhibit	35779906
Carcinoma Hepatocellular	Associate	16627981, 27310251, 27955658, 32184568, 36720665
Carcinoma Hepatocellular	Inhibit	25329885
Carcinoma Non Small Cell Lung	Associate	33378022
Carcinoma Skin Appendage	Associate	12190880, 15496400, 16900776, 17495026, 17851586, 31260673
Carcinoma Squamous Cell	Associate	25910754
Caroli disease isolated	Associate	27955658
Cerebrospinal Fluid Otorrhea	Associate	33031450
Cholesteatoma	Associate	20414373, 33031450
Chromosome Deletion	Associate	31085270
Colonic Neoplasms	Associate	39333335
Colorectal Neoplasms	Associate	28675510, 32364424
Craniodiaphyseal Dysplasia Autosomal Dominant	Associate	27955658
Crohn Disease	Associate	23071489
Deafness	Associate	19917957
Death	Associate	35779906
Dendritic Cell Sarcoma Follicular	Associate	26564005, 28621320
Endometrial Neoplasms	Associate	35779906
Familial cylindromatosis	Associate	12190880, 12917690, 14632188, 15086550, 15496400, 15854031, 16900776, 17851586, 18313383, 19917957, 20972631, 25501176, 25565632, 26329847, 26660106 View all (5 more)
Familial cylindromatosis	Inhibit	16301742, 18222923
Focal Epithelial Hyperplasia	Associate	20414373
Frontotemporal Dementia	Associate	36000313
Genetic Diseases Inborn	Associate	16713556
Glaucoma	Associate	21408173
Glioblastoma	Associate	26017671, 28901464
Head and Neck Neoplasms	Associate	28270164, 28295216
Hepatitis C	Inhibit	15133472
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25951887
HIV Infections	Associate	24760882
Hodgkin Disease	Associate	17606441
Inflammation	Inhibit	29166644, 33031450, 35025147, 37549179
Inflammation	Associate	34092220
LEOPARD Syndrome	Associate	19917957, 29955768, 31624251
Leukemia	Associate	37549179
Leukemia Lymphoma Adult T Cell	Associate	32024820
Leukemia Myeloid Acute	Associate	37549179
Leukemia Myelomonocytic Acute	Inhibit	37549179
Leukemia Plasma Cell	Associate	35770320
Liver Cirrhosis	Associate	36720665
Lupus Nephritis	Associate	29166644
Lymphoma	Associate	36922488
Lymphoma B Cell	Associate	36922488, 6407543
Lymphoma Large B Cell Diffuse	Inhibit	36922488
Lymphoma Mantle Cell	Inhibit	36922488
Lymphoma Non Hodgkin	Associate	26660106
Lymphoma T Cell	Associate	22362744
Melanoma	Associate	32252875, 34497368
Multiple Myeloma	Associate	17609426, 17692804, 17692805, 34269120
Multiple Pterygium Syndrome Autosomal Dominant	Associate	16900776
Nasopharyngeal Carcinoma	Associate	28098136, 35131382, 35562651, 38287022
Neoplasm Metastasis	Associate	26564005
Neoplasms	Inhibit	12190880, 15496400, 16627981, 16900776, 17495026, 17606441, 18222923, 18313383, 20414373, 24495516, 24760882, 25329885, 26969893, 28621320, 28900035 View all (15 more)
Neoplasms	Associate	15133472, 16713556, 19917957, 21552290, 23778141, 24974848, 25565632, 26329847, 26660106, 28270164, 28537672, 28572092, 29463883, 29569226, 32892208, 35131382, 35634245, 9783709 View all (3 more)
Neoplasms Basal Cell	Associate	29463883
Periodontitis	Associate	34092220
Polycythemia Vera	Inhibit	35025147
Polycythemia Vera	Associate	35025147
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22362744
Prostatic Neoplasms	Inhibit	38246916
Prostatic Neoplasms Castration Resistant	Associate	32091413
Psoriasis	Associate	19554025
Renal Insufficiency Chronic	Associate	29166644
Salivary Gland Neoplasms	Associate	16900776
Sexual Dysfunction Physiological	Associate	19917957
Skin Neoplasms	Associate	16713556, 25565632, 28270164, 31624251
Squamous Cell Carcinoma of Head and Neck	Inhibit	26982322
Squamous Cell Carcinoma of Head and Neck	Associate	31635163, 32892208, 35634245
Stomach Neoplasms	Associate	24495516, 26711782, 28537672
Stroke	Associate	32626985
Thymoma	Associate	24974848, 34622229, 34867976
Thyroid Cancer Papillary	Associate	25550803
Triple Negative Breast Neoplasms	Associate	30269739

CYLD (CYLD lysine 63 deubiquitinase)