PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)

Gene

• Entrez ID: 152926
• Gene name: Protein phosphatase, Mg2+/Mn2+ dependent 1K
• Gene symbol: PPM1K
• Synonyms (NCBI Gene): BCKDH, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07
• Chromosome: 4
• Chromosome location: 4q22.1
• Summary: This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permea

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT715656	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT715655	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT715654	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT654852	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654851	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654850	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT654849	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT654848	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT654847	hsa-miR-1976	HITS-CLIP	23824327
MIRT654846	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT622623	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT622623	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT622623	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT715656	hsa-miR-5571-5p	PAR-CLIP	27292025
MIRT715656	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT715655	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT715654	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT654852	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654851	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654850	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT654849	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT654848	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT654847	hsa-miR-1976	HITS-CLIP	23824327
MIRT654846	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT622623	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT622623	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT622625	hsa-miR-376a-5p	HITS-CLIP	23824327
MIRT622624	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT622622	hsa-miR-8061	HITS-CLIP	23824327
MIRT622623	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1254541	hsa-miR-106a	CLIP-seq
MIRT1254542	hsa-miR-106b	CLIP-seq
MIRT1254543	hsa-miR-1200	CLIP-seq
MIRT1254544	hsa-miR-1224-3p	CLIP-seq
MIRT1254545	hsa-miR-1245b-3p	CLIP-seq
MIRT1254546	hsa-miR-1270	CLIP-seq
MIRT1254547	hsa-miR-1272	CLIP-seq
MIRT1254548	hsa-miR-1276	CLIP-seq
MIRT1254549	hsa-miR-1279	CLIP-seq
MIRT1254550	hsa-miR-1290	CLIP-seq
MIRT1254551	hsa-miR-1299	CLIP-seq
MIRT1254552	hsa-miR-1322	CLIP-seq
MIRT1254553	hsa-miR-140-5p	CLIP-seq
MIRT1254554	hsa-miR-17	CLIP-seq
MIRT1254555	hsa-miR-1914	CLIP-seq
MIRT1254556	hsa-miR-203	CLIP-seq
MIRT1254557	hsa-miR-20a	CLIP-seq
MIRT1254558	hsa-miR-20b	CLIP-seq
MIRT1254559	hsa-miR-23a	CLIP-seq
MIRT1254560	hsa-miR-23b	CLIP-seq
MIRT1254561	hsa-miR-23c	CLIP-seq
MIRT1254562	hsa-miR-28-3p	CLIP-seq
MIRT1254563	hsa-miR-299-5p	CLIP-seq
MIRT1254564	hsa-miR-302a	CLIP-seq
MIRT1254565	hsa-miR-302b	CLIP-seq
MIRT1254566	hsa-miR-302c	CLIP-seq
MIRT1254567	hsa-miR-302d	CLIP-seq
MIRT1254568	hsa-miR-302e	CLIP-seq
MIRT1254569	hsa-miR-3117-5p	CLIP-seq
MIRT1254570	hsa-miR-3120-3p	CLIP-seq
MIRT1254571	hsa-miR-3148	CLIP-seq
MIRT1254572	hsa-miR-371-5p	CLIP-seq
MIRT1254573	hsa-miR-371b-5p	CLIP-seq
MIRT1254574	hsa-miR-372	CLIP-seq
MIRT1254575	hsa-miR-373	CLIP-seq
MIRT1254576	hsa-miR-3941	CLIP-seq
MIRT1254577	hsa-miR-3973	CLIP-seq
MIRT1254578	hsa-miR-4282	CLIP-seq
MIRT1254579	hsa-miR-4307	CLIP-seq
MIRT1254580	hsa-miR-4311	CLIP-seq
MIRT1254581	hsa-miR-432	CLIP-seq
MIRT1254582	hsa-miR-4330	CLIP-seq
MIRT1254583	hsa-miR-4432	CLIP-seq
MIRT1254584	hsa-miR-4434	CLIP-seq
MIRT1254585	hsa-miR-4438	CLIP-seq
MIRT1254586	hsa-miR-4452	CLIP-seq
MIRT1254587	hsa-miR-4477a	CLIP-seq
MIRT1254588	hsa-miR-4477b	CLIP-seq
MIRT1254589	hsa-miR-4516	CLIP-seq
MIRT1254590	hsa-miR-4517	CLIP-seq
MIRT1254591	hsa-miR-4531	CLIP-seq
MIRT1254592	hsa-miR-4635	CLIP-seq
MIRT1254593	hsa-miR-4639-3p	CLIP-seq
MIRT1254594	hsa-miR-4643	CLIP-seq
MIRT1254595	hsa-miR-466	CLIP-seq
MIRT1254596	hsa-miR-4666-5p	CLIP-seq
MIRT1254597	hsa-miR-4672	CLIP-seq
MIRT1254598	hsa-miR-4683	CLIP-seq
MIRT1254599	hsa-miR-4694-3p	CLIP-seq
MIRT1254600	hsa-miR-4698	CLIP-seq
MIRT1254601	hsa-miR-4729	CLIP-seq
MIRT1254602	hsa-miR-4731-5p	CLIP-seq
MIRT1254603	hsa-miR-4757-5p	CLIP-seq
MIRT1254604	hsa-miR-4789-3p	CLIP-seq
MIRT1254605	hsa-miR-4803	CLIP-seq
MIRT1254606	hsa-miR-5095	CLIP-seq
MIRT1254607	hsa-miR-512-3p	CLIP-seq
MIRT1254608	hsa-miR-512-5p	CLIP-seq
MIRT1254609	hsa-miR-519d	CLIP-seq
MIRT1254610	hsa-miR-520a-3p	CLIP-seq
MIRT1254611	hsa-miR-520b	CLIP-seq
MIRT1254612	hsa-miR-520c-3p	CLIP-seq
MIRT1254613	hsa-miR-520d-3p	CLIP-seq
MIRT1254614	hsa-miR-520e	CLIP-seq
MIRT1254615	hsa-miR-520g	CLIP-seq
MIRT1254616	hsa-miR-520h	CLIP-seq
MIRT1254617	hsa-miR-545	CLIP-seq
MIRT1254618	hsa-miR-548ae	CLIP-seq
MIRT1254619	hsa-miR-548aj	CLIP-seq
MIRT1254620	hsa-miR-548am	CLIP-seq
MIRT1254621	hsa-miR-548x	CLIP-seq
MIRT1254622	hsa-miR-577	CLIP-seq
MIRT1254623	hsa-miR-583	CLIP-seq
MIRT1254624	hsa-miR-606	CLIP-seq
MIRT1254625	hsa-miR-620	CLIP-seq
MIRT1254626	hsa-miR-7	CLIP-seq
MIRT1254627	hsa-miR-875-3p	CLIP-seq
MIRT1254628	hsa-miR-890	CLIP-seq
MIRT1254629	hsa-miR-93	CLIP-seq
MIRT1254573	hsa-miR-371b-5p	CLIP-seq
MIRT2075123	hsa-miR-122	CLIP-seq
MIRT1254548	hsa-miR-1276	CLIP-seq
MIRT1254550	hsa-miR-1290	CLIP-seq
MIRT2075124	hsa-miR-130a	CLIP-seq
MIRT2075125	hsa-miR-130b	CLIP-seq
MIRT2075126	hsa-miR-2052	CLIP-seq
MIRT1254562	hsa-miR-28-3p	CLIP-seq
MIRT2075127	hsa-miR-301a	CLIP-seq
MIRT2075128	hsa-miR-301b	CLIP-seq
MIRT2075129	hsa-miR-3135b	CLIP-seq
MIRT2075130	hsa-miR-3185	CLIP-seq
MIRT2075131	hsa-miR-3613-3p	CLIP-seq
MIRT2075132	hsa-miR-3652	CLIP-seq
MIRT2075133	hsa-miR-3666	CLIP-seq
MIRT2075134	hsa-miR-4295	CLIP-seq
MIRT2075135	hsa-miR-4430	CLIP-seq
MIRT2075136	hsa-miR-4511	CLIP-seq
MIRT2075137	hsa-miR-454	CLIP-seq
MIRT1254594	hsa-miR-4643	CLIP-seq
MIRT2075138	hsa-miR-4653-3p	CLIP-seq
MIRT1254595	hsa-miR-466	CLIP-seq
MIRT1254596	hsa-miR-4666-5p	CLIP-seq
MIRT1254600	hsa-miR-4698	CLIP-seq
MIRT2075139	hsa-miR-4709-3p	CLIP-seq
MIRT2075140	hsa-miR-4715-3p	CLIP-seq
MIRT1254604	hsa-miR-4789-3p	CLIP-seq
MIRT1254541	hsa-miR-106a	CLIP-seq
MIRT1254542	hsa-miR-106b	CLIP-seq
MIRT2075123	hsa-miR-122	CLIP-seq
MIRT1254544	hsa-miR-1224-3p	CLIP-seq
MIRT2301734	hsa-miR-128	CLIP-seq
MIRT2301735	hsa-miR-1297	CLIP-seq
MIRT2075124	hsa-miR-130a	CLIP-seq
MIRT2075125	hsa-miR-130b	CLIP-seq
MIRT2301736	hsa-miR-1343	CLIP-seq
MIRT1254554	hsa-miR-17	CLIP-seq
MIRT1254555	hsa-miR-1914	CLIP-seq
MIRT2301737	hsa-miR-197	CLIP-seq
MIRT1254556	hsa-miR-203	CLIP-seq
MIRT1254557	hsa-miR-20a	CLIP-seq
MIRT1254558	hsa-miR-20b	CLIP-seq
MIRT1254559	hsa-miR-23a	CLIP-seq
MIRT1254560	hsa-miR-23b	CLIP-seq
MIRT1254561	hsa-miR-23c	CLIP-seq
MIRT2301738	hsa-miR-26a	CLIP-seq
MIRT2301739	hsa-miR-26b	CLIP-seq
MIRT2301740	hsa-miR-27a	CLIP-seq
MIRT2301741	hsa-miR-27b	CLIP-seq
MIRT1254562	hsa-miR-28-3p	CLIP-seq
MIRT2075127	hsa-miR-301a	CLIP-seq
MIRT2075128	hsa-miR-301b	CLIP-seq
MIRT1254564	hsa-miR-302a	CLIP-seq
MIRT1254565	hsa-miR-302b	CLIP-seq
MIRT1254566	hsa-miR-302c	CLIP-seq
MIRT1254567	hsa-miR-302d	CLIP-seq
MIRT1254568	hsa-miR-302e	CLIP-seq
MIRT1254569	hsa-miR-3117-5p	CLIP-seq
MIRT1254570	hsa-miR-3120-3p	CLIP-seq
MIRT2301742	hsa-miR-3124-3p	CLIP-seq
MIRT2075129	hsa-miR-3135b	CLIP-seq
MIRT2301743	hsa-miR-3187-3p	CLIP-seq
MIRT2301744	hsa-miR-342-3p	CLIP-seq
MIRT2301745	hsa-miR-3622b-5p	CLIP-seq
MIRT2075132	hsa-miR-3652	CLIP-seq
MIRT2301746	hsa-miR-3663-5p	CLIP-seq
MIRT2075133	hsa-miR-3666	CLIP-seq
MIRT2301747	hsa-miR-3680	CLIP-seq
MIRT1254572	hsa-miR-371-5p	CLIP-seq
MIRT1254573	hsa-miR-371b-5p	CLIP-seq
MIRT1254574	hsa-miR-372	CLIP-seq
MIRT1254575	hsa-miR-373	CLIP-seq
MIRT2301748	hsa-miR-377	CLIP-seq
MIRT2301749	hsa-miR-3920	CLIP-seq
MIRT1254576	hsa-miR-3941	CLIP-seq
MIRT1254577	hsa-miR-3973	CLIP-seq
MIRT2301750	hsa-miR-410	CLIP-seq
MIRT2301751	hsa-miR-4274	CLIP-seq
MIRT2075134	hsa-miR-4295	CLIP-seq
MIRT1254579	hsa-miR-4307	CLIP-seq
MIRT2075135	hsa-miR-4430	CLIP-seq
MIRT1254583	hsa-miR-4432	CLIP-seq
MIRT1254584	hsa-miR-4434	CLIP-seq
MIRT2301752	hsa-miR-4435	CLIP-seq
MIRT1254585	hsa-miR-4438	CLIP-seq
MIRT1254586	hsa-miR-4452	CLIP-seq
MIRT2301753	hsa-miR-4465	CLIP-seq
MIRT2075136	hsa-miR-4511	CLIP-seq
MIRT1254589	hsa-miR-4516	CLIP-seq
MIRT2301754	hsa-miR-4519	CLIP-seq
MIRT1254591	hsa-miR-4531	CLIP-seq
MIRT2301755	hsa-miR-4536	CLIP-seq
MIRT2075137	hsa-miR-454	CLIP-seq
MIRT1254592	hsa-miR-4635	CLIP-seq
MIRT1254593	hsa-miR-4639-3p	CLIP-seq
MIRT1254594	hsa-miR-4643	CLIP-seq
MIRT2301756	hsa-miR-4652-3p	CLIP-seq
MIRT1254595	hsa-miR-466	CLIP-seq
MIRT1254596	hsa-miR-4666-5p	CLIP-seq
MIRT1254597	hsa-miR-4672	CLIP-seq
MIRT1254599	hsa-miR-4694-3p	CLIP-seq
MIRT2301757	hsa-miR-4701-5p	CLIP-seq
MIRT2301758	hsa-miR-4704-3p	CLIP-seq
MIRT2301759	hsa-miR-4716-5p	CLIP-seq
MIRT1254602	hsa-miR-4731-5p	CLIP-seq
MIRT2301760	hsa-miR-4755-3p	CLIP-seq
MIRT1254603	hsa-miR-4757-5p	CLIP-seq
MIRT2301761	hsa-miR-4772-3p	CLIP-seq
MIRT2301762	hsa-miR-4775	CLIP-seq
MIRT2301763	hsa-miR-4781-3p	CLIP-seq
MIRT1254604	hsa-miR-4789-3p	CLIP-seq
MIRT2301764	hsa-miR-4795-3p	CLIP-seq
MIRT2301765	hsa-miR-4796-5p	CLIP-seq
MIRT2301766	hsa-miR-4798-3p	CLIP-seq
MIRT2301767	hsa-miR-495	CLIP-seq
MIRT2301768	hsa-miR-499-3p	CLIP-seq
MIRT2301769	hsa-miR-499a-3p	CLIP-seq
MIRT1254606	hsa-miR-5095	CLIP-seq
MIRT2301770	hsa-miR-5096	CLIP-seq
MIRT1254607	hsa-miR-512-3p	CLIP-seq
MIRT1254608	hsa-miR-512-5p	CLIP-seq
MIRT1254609	hsa-miR-519d	CLIP-seq
MIRT1254610	hsa-miR-520a-3p	CLIP-seq
MIRT1254611	hsa-miR-520b	CLIP-seq
MIRT1254612	hsa-miR-520c-3p	CLIP-seq
MIRT1254613	hsa-miR-520d-3p	CLIP-seq
MIRT1254614	hsa-miR-520e	CLIP-seq
MIRT1254615	hsa-miR-520g	CLIP-seq
MIRT1254616	hsa-miR-520h	CLIP-seq
MIRT1254617	hsa-miR-545	CLIP-seq
MIRT2301771	hsa-miR-548s	CLIP-seq
MIRT2301772	hsa-miR-548u	CLIP-seq
MIRT1254622	hsa-miR-577	CLIP-seq
MIRT2301773	hsa-miR-579	CLIP-seq
MIRT2301774	hsa-miR-587	CLIP-seq
MIRT2301775	hsa-miR-588	CLIP-seq
MIRT2301776	hsa-miR-654-3p	CLIP-seq
MIRT1254626	hsa-miR-7	CLIP-seq
MIRT1254629	hsa-miR-93	CLIP-seq
MIRT2301755	hsa-miR-4536	CLIP-seq
MIRT1254550	hsa-miR-1290	CLIP-seq
MIRT2301734	hsa-miR-128	CLIP-seq
MIRT2301740	hsa-miR-27a	CLIP-seq
MIRT2301741	hsa-miR-27b	CLIP-seq
MIRT1254594	hsa-miR-4643	CLIP-seq
MIRT1254595	hsa-miR-466	CLIP-seq
MIRT1254604	hsa-miR-4789-3p	CLIP-seq
MIRT2075123	hsa-miR-122	CLIP-seq
MIRT2075124	hsa-miR-130a	CLIP-seq
MIRT2075125	hsa-miR-130b	CLIP-seq
MIRT2075127	hsa-miR-301a	CLIP-seq
MIRT2075128	hsa-miR-301b	CLIP-seq
MIRT2075129	hsa-miR-3135b	CLIP-seq
MIRT2457049	hsa-miR-346	CLIP-seq
MIRT2301745	hsa-miR-3622b-5p	CLIP-seq
MIRT2075132	hsa-miR-3652	CLIP-seq
MIRT2075133	hsa-miR-3666	CLIP-seq
MIRT2457050	hsa-miR-3934	CLIP-seq
MIRT2457051	hsa-miR-4288	CLIP-seq
MIRT2075134	hsa-miR-4295	CLIP-seq
MIRT2075135	hsa-miR-4430	CLIP-seq
MIRT2075137	hsa-miR-454	CLIP-seq
MIRT2075140	hsa-miR-4715-3p	CLIP-seq
MIRT2457052	hsa-miR-4727-5p	CLIP-seq
MIRT2457053	hsa-miR-4769-3p	CLIP-seq
MIRT1254606	hsa-miR-5095	CLIP-seq
MIRT2457054	hsa-miR-552	CLIP-seq
MIRT2457055	hsa-miR-632	CLIP-seq
MIRT2598480	hsa-miR-105	CLIP-seq
MIRT2075123	hsa-miR-122	CLIP-seq
MIRT2598481	hsa-miR-1238	CLIP-seq
MIRT2598482	hsa-miR-1258	CLIP-seq
MIRT1254547	hsa-miR-1272	CLIP-seq
MIRT2598483	hsa-miR-1273d	CLIP-seq
MIRT2301734	hsa-miR-128	CLIP-seq
MIRT2301735	hsa-miR-1297	CLIP-seq
MIRT1254551	hsa-miR-1299	CLIP-seq
MIRT2075124	hsa-miR-130a	CLIP-seq
MIRT2075125	hsa-miR-130b	CLIP-seq
MIRT1254552	hsa-miR-1322	CLIP-seq
MIRT2301736	hsa-miR-1343	CLIP-seq
MIRT2598484	hsa-miR-147b	CLIP-seq
MIRT2598485	hsa-miR-186	CLIP-seq
MIRT2075126	hsa-miR-2052	CLIP-seq
MIRT2598486	hsa-miR-210	CLIP-seq
MIRT2598487	hsa-miR-22	CLIP-seq
MIRT2301738	hsa-miR-26a	CLIP-seq
MIRT2301739	hsa-miR-26b	CLIP-seq
MIRT2301740	hsa-miR-27a	CLIP-seq
MIRT2301741	hsa-miR-27b	CLIP-seq
MIRT2075127	hsa-miR-301a	CLIP-seq
MIRT2075128	hsa-miR-301b	CLIP-seq
MIRT1254569	hsa-miR-3117-5p	CLIP-seq
MIRT2301742	hsa-miR-3124-3p	CLIP-seq
MIRT2598488	hsa-miR-3133	CLIP-seq
MIRT2075129	hsa-miR-3135b	CLIP-seq
MIRT1254571	hsa-miR-3148	CLIP-seq
MIRT2598489	hsa-miR-3174	CLIP-seq
MIRT2075130	hsa-miR-3185	CLIP-seq
MIRT2075131	hsa-miR-3613-3p	CLIP-seq
MIRT2598490	hsa-miR-361-5p	CLIP-seq
MIRT2301745	hsa-miR-3622b-5p	CLIP-seq
MIRT2598491	hsa-miR-3646	CLIP-seq
MIRT2075132	hsa-miR-3652	CLIP-seq
MIRT2598492	hsa-miR-3662	CLIP-seq
MIRT2075133	hsa-miR-3666	CLIP-seq
MIRT2598493	hsa-miR-3671	CLIP-seq
MIRT2598494	hsa-miR-3713	CLIP-seq
MIRT2598495	hsa-miR-4266	CLIP-seq
MIRT2598496	hsa-miR-4276	CLIP-seq
MIRT1254578	hsa-miR-4282	CLIP-seq
MIRT2075134	hsa-miR-4295	CLIP-seq
MIRT2598497	hsa-miR-4328	CLIP-seq
MIRT2598498	hsa-miR-4424	CLIP-seq
MIRT2075135	hsa-miR-4430	CLIP-seq
MIRT1254583	hsa-miR-4432	CLIP-seq
MIRT2301753	hsa-miR-4465	CLIP-seq
MIRT1254587	hsa-miR-4477a	CLIP-seq
MIRT2075136	hsa-miR-4511	CLIP-seq
MIRT1254590	hsa-miR-4517	CLIP-seq
MIRT2075137	hsa-miR-454	CLIP-seq
MIRT1254593	hsa-miR-4639-3p	CLIP-seq
MIRT1254594	hsa-miR-4643	CLIP-seq
MIRT1254595	hsa-miR-466	CLIP-seq
MIRT2598499	hsa-miR-4684-3p	CLIP-seq
MIRT2075139	hsa-miR-4709-3p	CLIP-seq
MIRT2075140	hsa-miR-4715-3p	CLIP-seq
MIRT2598500	hsa-miR-4724-5p	CLIP-seq
MIRT1254601	hsa-miR-4729	CLIP-seq
MIRT1254604	hsa-miR-4789-3p	CLIP-seq
MIRT1254605	hsa-miR-4803	CLIP-seq
MIRT2598501	hsa-miR-489	CLIP-seq
MIRT2301767	hsa-miR-495	CLIP-seq
MIRT2598502	hsa-miR-526b	CLIP-seq
MIRT2598503	hsa-miR-548a-3p	CLIP-seq
MIRT1254618	hsa-miR-548ae	CLIP-seq
MIRT1254619	hsa-miR-548aj	CLIP-seq
MIRT1254620	hsa-miR-548am	CLIP-seq
MIRT2598504	hsa-miR-548c-3p	CLIP-seq
MIRT2598505	hsa-miR-548e	CLIP-seq
MIRT2598506	hsa-miR-548f	CLIP-seq
MIRT2598507	hsa-miR-548g	CLIP-seq
MIRT2301772	hsa-miR-548u	CLIP-seq
MIRT1254621	hsa-miR-548x	CLIP-seq
MIRT2598508	hsa-miR-578	CLIP-seq
MIRT2301773	hsa-miR-579	CLIP-seq
MIRT2301774	hsa-miR-587	CLIP-seq
MIRT2598509	hsa-miR-607	CLIP-seq
MIRT2598510	hsa-miR-769-5p	CLIP-seq
MIRT1254627	hsa-miR-875-3p	CLIP-seq
MIRT2598511	hsa-miR-921	CLIP-seq
MIRT2598512	hsa-miR-924	CLIP-seq
MIRT2598513	hsa-miR-933	CLIP-seq
MIRT2598514	hsa-miR-944	CLIP-seq
MIRT2075123	hsa-miR-122	CLIP-seq
MIRT2598482	hsa-miR-1258	CLIP-seq
MIRT1254547	hsa-miR-1272	CLIP-seq
MIRT2301734	hsa-miR-128	CLIP-seq
MIRT2301735	hsa-miR-1297	CLIP-seq
MIRT1254551	hsa-miR-1299	CLIP-seq
MIRT2075124	hsa-miR-130a	CLIP-seq
MIRT2075125	hsa-miR-130b	CLIP-seq
MIRT1254552	hsa-miR-1322	CLIP-seq
MIRT2301736	hsa-miR-1343	CLIP-seq
MIRT2598484	hsa-miR-147b	CLIP-seq
MIRT2598486	hsa-miR-210	CLIP-seq
MIRT2301738	hsa-miR-26a	CLIP-seq
MIRT2301739	hsa-miR-26b	CLIP-seq
MIRT2301740	hsa-miR-27a	CLIP-seq
MIRT2301741	hsa-miR-27b	CLIP-seq
MIRT2075127	hsa-miR-301a	CLIP-seq
MIRT2075128	hsa-miR-301b	CLIP-seq
MIRT1254569	hsa-miR-3117-5p	CLIP-seq
MIRT2301742	hsa-miR-3124-3p	CLIP-seq
MIRT2075129	hsa-miR-3135b	CLIP-seq
MIRT1254571	hsa-miR-3148	CLIP-seq
MIRT2598489	hsa-miR-3174	CLIP-seq
MIRT2598490	hsa-miR-361-5p	CLIP-seq
MIRT2301745	hsa-miR-3622b-5p	CLIP-seq
MIRT2075132	hsa-miR-3652	CLIP-seq
MIRT2075133	hsa-miR-3666	CLIP-seq
MIRT2598494	hsa-miR-3713	CLIP-seq
MIRT2598495	hsa-miR-4266	CLIP-seq
MIRT2598496	hsa-miR-4276	CLIP-seq
MIRT1254578	hsa-miR-4282	CLIP-seq
MIRT2075134	hsa-miR-4295	CLIP-seq
MIRT2598497	hsa-miR-4328	CLIP-seq
MIRT2598498	hsa-miR-4424	CLIP-seq
MIRT2075135	hsa-miR-4430	CLIP-seq
MIRT1254583	hsa-miR-4432	CLIP-seq
MIRT2301753	hsa-miR-4465	CLIP-seq
MIRT1254590	hsa-miR-4517	CLIP-seq
MIRT2075137	hsa-miR-454	CLIP-seq
MIRT1254593	hsa-miR-4639-3p	CLIP-seq
MIRT1254594	hsa-miR-4643	CLIP-seq
MIRT1254595	hsa-miR-466	CLIP-seq
MIRT2598500	hsa-miR-4724-5p	CLIP-seq
MIRT1254604	hsa-miR-4789-3p	CLIP-seq
MIRT1254605	hsa-miR-4803	CLIP-seq
MIRT2598501	hsa-miR-489	CLIP-seq
MIRT2598502	hsa-miR-526b	CLIP-seq
MIRT2598503	hsa-miR-548a-3p	CLIP-seq
MIRT1254618	hsa-miR-548ae	CLIP-seq
MIRT1254619	hsa-miR-548aj	CLIP-seq
MIRT1254620	hsa-miR-548am	CLIP-seq
MIRT2598505	hsa-miR-548e	CLIP-seq
MIRT2598506	hsa-miR-548f	CLIP-seq
MIRT2598507	hsa-miR-548g	CLIP-seq
MIRT2301772	hsa-miR-548u	CLIP-seq
MIRT1254621	hsa-miR-548x	CLIP-seq
MIRT2598508	hsa-miR-578	CLIP-seq
MIRT2301773	hsa-miR-579	CLIP-seq
MIRT2301774	hsa-miR-587	CLIP-seq
MIRT2598510	hsa-miR-769-5p	CLIP-seq
MIRT1254627	hsa-miR-875-3p	CLIP-seq
MIRT1254628	hsa-miR-890	CLIP-seq
MIRT2598511	hsa-miR-921	CLIP-seq
MIRT2598513	hsa-miR-933	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	17374715, 22291014, 29779826
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS
GO:0005515	Function	Protein binding	IPI	22291014, 25416956, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	ISS
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0009083	Process	Branched-chain amino acid catabolic process	IMP	29779826
GO:0016787	Function	Hydrolase activity	IEA
GO:0030145	Function	Manganese ion binding	IDA	22291014
GO:0043169	Function	Cation binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047385	Function	[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity	IEA
GO:1902108	Process	Regulation of mitochondrial membrane permeability involved in apoptotic process	IEA
GO:1902531	Process	Regulation of intracellular signal transduction	IBA

Other IDs

• MIM: 611065
• HGNC: 25415
• e!Ensembl: ENSG00000163644

Protein

• UniProt ID: Q8N3J5
• Protein name: Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphop
• Protein function: Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and l
• PDB: 2IQ1, 4DA1, 6AK7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00481	PP2C	96 → 339	Protein phosphatase 2C	Family

• Sequence:

  MSTAALITLVRSGGNQVRRRVLLSSRLLQDDRRVTPTCHSSTSEPRCSRFDPDGSGSPAT
  WDNFGIWDNRIDEPILLPPSIKYGKPIPKISLENVGCASQIGKRKENEDRFDFAQLTDEV
  LYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSSHARLSAD
  ATLLTSGTTATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKC
  GGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADDSFLVLTTDGI
  NFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAWGKYKNSEINFS
  FSRSFASSGRWA

• Sequence length: 372

Pathways

Reactome:

Branched-chain amino acid catabolism

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Maple syrup urine disease, mild variant	Pathogenic	rs2476675975	RCV004556889	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GESTATIONAL DIABETES	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERURICEMIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTERMEDIATE MAPLE SYRUP URINE DISEASE	—	Disgenet, GWAS catalog, Orphanet Disgenet, GWAS catalog, Orphanet Disgenet, GWAS catalog, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAPLE SYRUP URINE DISEASE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PPM1K-related disorder	Likely benign; Benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinogenesis	Associate	36417878	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Inhibit	23376929	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	36417878	★☆☆☆☆ Found in Text Mining only
Carcinoma Transitional Cell	Associate	31805718	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Associate	30451284	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	36104170	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	28768654, 30451284	★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Associate	31340305	★☆☆☆☆ Found in Text Mining only
Heredodegenerative Disorders Nervous System	Associate	30451284	★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Associate	28768654	★☆☆☆☆ Found in Text Mining only
Maple Syrup Urine Disease	Associate	30451284	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Associate	30537300	★☆☆☆☆ Found in Text Mining only
Tetralogy of Fallot	Associate	31340305	★☆☆☆☆ Found in Text Mining only
Weight Loss	Associate	28768654	★☆☆☆☆ Found in Text Mining only