PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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152926 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Protein phosphatase, Mg2+/Mn2+ dependent 1K |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PPM1K |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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BCKDH, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07 |
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Chromosome
Chromosome number
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4 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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4q22.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permea |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q8N3J5 | ||||||||||
| Protein name | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphop | ||||||||||
| Protein function | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and l | ||||||||||
| PDB | 2IQ1 , 4DA1 , 6AK7 | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 372 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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