CTSZ (cathepsin Z)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1522
Gene name Gene Name - the full gene name approved by the HGNC.
Cathepsin Z
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CTSZ
Synonyms (NCBI Gene) Gene synonyms aliases
CTSX
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.32
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. T
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
miRTarBase ID miRNA Experiments Reference
MIRT021991 hsa-miR-128-3p Sequencing 20371350
MIRT029430 hsa-miR-26b-5p Microarray 19088304
MIRT041024 hsa-miR-505-3p CLASH 23622248
MIRT039629 hsa-miR-615-3p CLASH 23622248
MIRT916086 hsa-miR-1264 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(31)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0002003 Process Angiotensin maturation TAS
GO:0004180 Function Carboxypeptidase activity IMP 19433310
GO:0004197 Function Cysteine-type endopeptidase activity IBA 21873635
GO:0005515 Function Protein binding IPI 21516116, 25416956, 31515488, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603169 2547 ENSG00000101160
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9UBR2
Protein name Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X)
Protein function Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity).
PDB 1DEU , 1EF7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00112 Peptidase_C1 62 → 296 Papain family cysteine protease Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10653163}.
Sequence
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Lysosome
Apoptosis 		  Metabolism of Angiotensinogen to Angiotensins
COPII-mediated vesicle transport
Lysosome Vesicle Biogenesis
Cargo concentration in the ER
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 17330099
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Show/Hide Text Mining Associations (46)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 35444189, 38250763
Alagille Syndrome Associate 30087368
Alzheimer Disease Associate 10745011
Alzheimer Disease Stimulate 39838438
Arthritis Rheumatoid Associate 10745011
Arthritis Rheumatoid Stimulate 35008858
Cardiovascular Diseases Associate 32928870
Cell Transformation Neoplastic Associate 34378678, 35444189
Charcot Marie Tooth disease Type 1D Stimulate 39838438
Chondrocalcinosis 2 Associate 35008858