PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)

Gene

• Entrez ID: 151742
• Gene name: Protein phosphatase, Mg2+/Mn2+ dependent 1L
• Gene symbol: PPM1L
• Synonyms (NCBI Gene): PP2C-epsilon, PP2CE, PPM1-LIKE
• Chromosome: 3
• Chromosome location: 3q25.33-q26.1
• Summary: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that le

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017625	hsa-miR-335-5p	Microarray	18185580
MIRT030870	hsa-miR-21-5p	Sequencing	20371350
MIRT672807	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT672806	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672805	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT672804	hsa-miR-4456	HITS-CLIP	23824327
MIRT672803	hsa-miR-138-5p	HITS-CLIP	23824327
MIRT672802	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT672801	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT492562	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT672800	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT672799	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT672798	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672797	hsa-miR-8071	HITS-CLIP	23824327
MIRT672796	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT672795	hsa-miR-3165	HITS-CLIP	23824327
MIRT672793	hsa-miR-8056	HITS-CLIP	23824327
MIRT672794	hsa-miR-7977	HITS-CLIP	23824327
MIRT672792	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT672791	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT672790	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT672789	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT672788	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT672787	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT672786	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT672785	hsa-miR-3689c	HITS-CLIP	23824327
MIRT672784	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT672783	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672782	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT672781	hsa-miR-3122	HITS-CLIP	23824327
MIRT672780	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT672779	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT672778	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT654845	hsa-miR-103b	HITS-CLIP	23824327
MIRT654844	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT654843	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT654842	hsa-miR-544a	HITS-CLIP	23824327
MIRT654841	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT654840	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT654839	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654838	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT654837	hsa-miR-4501	HITS-CLIP	23824327
MIRT654836	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT654835	hsa-miR-31-5p	HITS-CLIP	23824327
MIRT654834	hsa-miR-6809-5p	HITS-CLIP	23824327
MIRT555409	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT555408	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT555407	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT555405	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT555406	hsa-miR-940	PAR-CLIP	21572407
MIRT555404	hsa-miR-3929	PAR-CLIP	21572407
MIRT555403	hsa-miR-4419b	PAR-CLIP	21572407
MIRT555402	hsa-miR-4478	PAR-CLIP	21572407
MIRT555401	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT492574	hsa-miR-4459	PAR-CLIP	21572407
MIRT555400	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT555399	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT555398	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT555397	hsa-miR-767-3p	PAR-CLIP	21572407
MIRT555396	hsa-miR-4790-3p	PAR-CLIP	21572407
MIRT555395	hsa-miR-1827	PAR-CLIP	21572407
MIRT555394	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT555393	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT555392	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT555391	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT555390	hsa-miR-3650	PAR-CLIP	21572407
MIRT555389	hsa-miR-665	PAR-CLIP	21572407
MIRT492584	hsa-miR-6165	PAR-CLIP	23592263
MIRT492583	hsa-miR-4779	PAR-CLIP	23592263
MIRT492582	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT492581	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT492580	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT492579	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT492578	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT492577	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT492575	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT492576	hsa-miR-761	PAR-CLIP	23592263
MIRT492574	hsa-miR-4459	PAR-CLIP	23592263
MIRT492573	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT492572	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT492570	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT492569	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT492568	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT492566	hsa-miR-8085	PAR-CLIP	23592263
MIRT492567	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT492565	hsa-miR-3175	PAR-CLIP	23592263
MIRT492564	hsa-miR-23a-5p	PAR-CLIP	23592263
MIRT492563	hsa-miR-23b-5p	PAR-CLIP	23592263
MIRT492562	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT672807	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT672806	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672805	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT672804	hsa-miR-4456	HITS-CLIP	23824327
MIRT672803	hsa-miR-138-5p	HITS-CLIP	23824327
MIRT672802	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT672801	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT492562	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT672800	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT672799	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT672798	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672797	hsa-miR-8071	HITS-CLIP	23824327
MIRT672796	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT672795	hsa-miR-3165	HITS-CLIP	23824327
MIRT672793	hsa-miR-8056	HITS-CLIP	23824327
MIRT672794	hsa-miR-7977	HITS-CLIP	23824327
MIRT672792	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT672791	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT672790	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT672789	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT672788	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT672787	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT672786	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT672785	hsa-miR-3689c	HITS-CLIP	23824327
MIRT672784	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT672783	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672782	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT672781	hsa-miR-3122	HITS-CLIP	23824327
MIRT672780	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT672779	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT672778	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT654845	hsa-miR-103b	HITS-CLIP	23824327
MIRT654844	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT654843	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT654842	hsa-miR-544a	HITS-CLIP	23824327
MIRT654841	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT654840	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT654839	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654838	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT654837	hsa-miR-4501	HITS-CLIP	23824327
MIRT654836	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT654835	hsa-miR-31-5p	HITS-CLIP	23824327
MIRT654834	hsa-miR-6809-5p	HITS-CLIP	23824327
MIRT555409	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT555408	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT555407	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT555405	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT555406	hsa-miR-940	PAR-CLIP	21572407
MIRT555404	hsa-miR-3929	PAR-CLIP	21572407
MIRT555403	hsa-miR-4419b	PAR-CLIP	21572407
MIRT555402	hsa-miR-4478	PAR-CLIP	21572407
MIRT555401	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT492574	hsa-miR-4459	PAR-CLIP	21572407
MIRT555400	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT555399	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT555398	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT555397	hsa-miR-767-3p	PAR-CLIP	21572407
MIRT555396	hsa-miR-4790-3p	PAR-CLIP	21572407
MIRT555395	hsa-miR-1827	PAR-CLIP	21572407
MIRT555394	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT555393	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT555392	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT555391	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT555390	hsa-miR-3650	PAR-CLIP	21572407
MIRT555389	hsa-miR-665	PAR-CLIP	21572407
MIRT492584	hsa-miR-6165	PAR-CLIP	23592263
MIRT492583	hsa-miR-4779	PAR-CLIP	23592263
MIRT492582	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT492581	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT492580	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT492579	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT492578	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT492577	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT492575	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT492576	hsa-miR-761	PAR-CLIP	23592263
MIRT492574	hsa-miR-4459	PAR-CLIP	23592263
MIRT492573	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT492572	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT492571	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT492570	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT492569	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT492568	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT492566	hsa-miR-8085	PAR-CLIP	23592263
MIRT492567	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT492565	hsa-miR-3175	PAR-CLIP	23592263
MIRT492564	hsa-miR-23a-5p	PAR-CLIP	23592263
MIRT492563	hsa-miR-23b-5p	PAR-CLIP	23592263
MIRT492562	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT1254630	hsa-miR-103a	CLIP-seq
MIRT1254631	hsa-miR-107	CLIP-seq
MIRT1254632	hsa-miR-1179	CLIP-seq
MIRT1254633	hsa-miR-1184	CLIP-seq
MIRT1254634	hsa-miR-1202	CLIP-seq
MIRT1254635	hsa-miR-1231	CLIP-seq
MIRT1254636	hsa-miR-124	CLIP-seq
MIRT1254637	hsa-miR-1255a	CLIP-seq
MIRT1254638	hsa-miR-1255b	CLIP-seq
MIRT1254639	hsa-miR-125a-3p	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254641	hsa-miR-1321	CLIP-seq
MIRT1254642	hsa-miR-134	CLIP-seq
MIRT1254643	hsa-miR-139-5p	CLIP-seq
MIRT1254644	hsa-miR-141	CLIP-seq
MIRT1254645	hsa-miR-188-3p	CLIP-seq
MIRT1254646	hsa-miR-1976	CLIP-seq
MIRT1254647	hsa-miR-200a	CLIP-seq
MIRT1254648	hsa-miR-204	CLIP-seq
MIRT1254649	hsa-miR-211	CLIP-seq
MIRT1254650	hsa-miR-24	CLIP-seq
MIRT1254651	hsa-miR-300	CLIP-seq
MIRT1254652	hsa-miR-3118	CLIP-seq
MIRT1254653	hsa-miR-3121-5p	CLIP-seq
MIRT1254654	hsa-miR-3146	CLIP-seq
MIRT1254655	hsa-miR-3164	CLIP-seq
MIRT1254656	hsa-miR-330-3p	CLIP-seq
MIRT1254657	hsa-miR-331-3p	CLIP-seq
MIRT1254658	hsa-miR-342-5p	CLIP-seq
MIRT1254659	hsa-miR-3646	CLIP-seq
MIRT1254660	hsa-miR-3667-5p	CLIP-seq
MIRT1254661	hsa-miR-3677-5p	CLIP-seq
MIRT1254662	hsa-miR-3691-5p	CLIP-seq
MIRT1254663	hsa-miR-3714	CLIP-seq
MIRT1254664	hsa-miR-381	CLIP-seq
MIRT1254665	hsa-miR-3910	CLIP-seq
MIRT1254666	hsa-miR-3934	CLIP-seq
MIRT1254667	hsa-miR-3972	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT1254669	hsa-miR-425	CLIP-seq
MIRT1254670	hsa-miR-4270	CLIP-seq
MIRT1254671	hsa-miR-4329	CLIP-seq
MIRT1254672	hsa-miR-4421	CLIP-seq
MIRT1254673	hsa-miR-4422	CLIP-seq
MIRT1254674	hsa-miR-4437	CLIP-seq
MIRT1254675	hsa-miR-4441	CLIP-seq
MIRT1254676	hsa-miR-4450	CLIP-seq
MIRT1254677	hsa-miR-4474-5p	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254679	hsa-miR-4521	CLIP-seq
MIRT1254680	hsa-miR-4522	CLIP-seq
MIRT1254681	hsa-miR-4525	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT1254683	hsa-miR-4651	CLIP-seq
MIRT1254684	hsa-miR-4664-5p	CLIP-seq
MIRT1254685	hsa-miR-4666-3p	CLIP-seq
MIRT1254686	hsa-miR-4667-5p	CLIP-seq
MIRT1254687	hsa-miR-4674	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254689	hsa-miR-4699-3p	CLIP-seq
MIRT1254690	hsa-miR-4700-5p	CLIP-seq
MIRT1254691	hsa-miR-4716-5p	CLIP-seq
MIRT1254692	hsa-miR-4733-3p	CLIP-seq
MIRT1254693	hsa-miR-4739	CLIP-seq
MIRT1254694	hsa-miR-4755-3p	CLIP-seq
MIRT1254695	hsa-miR-4756-5p	CLIP-seq
MIRT1254696	hsa-miR-4786-5p	CLIP-seq
MIRT1254697	hsa-miR-4789-3p	CLIP-seq
MIRT1254698	hsa-miR-488	CLIP-seq
MIRT1254699	hsa-miR-506	CLIP-seq
MIRT1254700	hsa-miR-520d-5p	CLIP-seq
MIRT1254701	hsa-miR-524-5p	CLIP-seq
MIRT1254702	hsa-miR-532-3p	CLIP-seq
MIRT1254703	hsa-miR-548p	CLIP-seq
MIRT1254704	hsa-miR-608	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq
MIRT1254706	hsa-miR-637	CLIP-seq
MIRT1254707	hsa-miR-642b	CLIP-seq
MIRT1254708	hsa-miR-651	CLIP-seq
MIRT1254709	hsa-miR-653	CLIP-seq
MIRT1254710	hsa-miR-654-3p	CLIP-seq
MIRT1254711	hsa-miR-764	CLIP-seq
MIRT1254712	hsa-miR-769-5p	CLIP-seq
MIRT2075141	hsa-miR-1197	CLIP-seq
MIRT2075142	hsa-miR-1208	CLIP-seq
MIRT2075143	hsa-miR-1243	CLIP-seq
MIRT1254637	hsa-miR-1255a	CLIP-seq
MIRT1254638	hsa-miR-1255b	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254643	hsa-miR-139-5p	CLIP-seq
MIRT2075144	hsa-miR-148a	CLIP-seq
MIRT2075145	hsa-miR-148b	CLIP-seq
MIRT2075146	hsa-miR-152	CLIP-seq
MIRT1254646	hsa-miR-1976	CLIP-seq
MIRT2075147	hsa-miR-3148	CLIP-seq
MIRT2075148	hsa-miR-3153	CLIP-seq
MIRT2075149	hsa-miR-371-5p	CLIP-seq
MIRT2075150	hsa-miR-371b-5p	CLIP-seq
MIRT2075151	hsa-miR-3978	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT2075152	hsa-miR-4254	CLIP-seq
MIRT2075153	hsa-miR-4311	CLIP-seq
MIRT1254672	hsa-miR-4421	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT2075154	hsa-miR-4639-3p	CLIP-seq
MIRT2075155	hsa-miR-4668-5p	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254692	hsa-miR-4733-3p	CLIP-seq
MIRT2075156	hsa-miR-513c	CLIP-seq
MIRT2075157	hsa-miR-514b-5p	CLIP-seq
MIRT1254700	hsa-miR-520d-5p	CLIP-seq
MIRT1254701	hsa-miR-524-5p	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq
MIRT1254634	hsa-miR-1202	CLIP-seq
MIRT1254639	hsa-miR-125a-3p	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254642	hsa-miR-134	CLIP-seq
MIRT1254643	hsa-miR-139-5p	CLIP-seq
MIRT1254644	hsa-miR-141	CLIP-seq
MIRT1254647	hsa-miR-200a	CLIP-seq
MIRT2301777	hsa-miR-205	CLIP-seq
MIRT1254652	hsa-miR-3118	CLIP-seq
MIRT2075148	hsa-miR-3153	CLIP-seq
MIRT1254655	hsa-miR-3164	CLIP-seq
MIRT2301778	hsa-miR-3187-3p	CLIP-seq
MIRT2301779	hsa-miR-3926	CLIP-seq
MIRT1254667	hsa-miR-3972	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT2301780	hsa-miR-4420	CLIP-seq
MIRT2301781	hsa-miR-4435	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254680	hsa-miR-4522	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254689	hsa-miR-4699-3p	CLIP-seq
MIRT2301782	hsa-miR-4701-5p	CLIP-seq
MIRT1254694	hsa-miR-4755-3p	CLIP-seq
MIRT2301783	hsa-miR-513a-5p	CLIP-seq
MIRT2301784	hsa-miR-548s	CLIP-seq
MIRT2301785	hsa-miR-570	CLIP-seq
MIRT2301786	hsa-miR-588	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq
MIRT1254640	hsa-miR-1270	CLIP-seq
MIRT1254668	hsa-miR-409-3p	CLIP-seq
MIRT1254678	hsa-miR-450b-5p	CLIP-seq
MIRT1254682	hsa-miR-4534	CLIP-seq
MIRT1254688	hsa-miR-4683	CLIP-seq
MIRT1254705	hsa-miR-620	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0007165	Process	Signal transduction	IBA
GO:0007178	Process	Cell surface receptor protein serine/threonine kinase signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	TAS
GO:0043169	Function	Cation binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

Other IDs

• MIM: 611931
• HGNC: 16381
• e!Ensembl: ENSG00000163590

Protein

• UniProt ID: Q5SGD2
• Protein name: Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon)
• Protein function: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00481	PP2C	91 → 344	Protein phosphatase 2C	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas. {ECO:0000269|PubMed:15560375}.
• Sequence:

  MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVK
  GKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTH
  PSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREM
  LEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERK
  RIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILA
  SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ
  

• Sequence length: 360

Pathways

Reactome:

Sphingolipid de novo biosynthesis