Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
151647
Gene name Gene Name - the full gene name approved by the HGNC.
TAFA chemokine like family member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAFA4
Synonyms (NCBI Gene) Gene synonyms aliases
FAM19A4, TAFA-4
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p14.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956
GO:0005615 Component Extracellular space IBA 21873635
GO:0005615 Component Extracellular space ISS
GO:0006909 Process Phagocytosis IBA 21873635
GO:0006909 Process Phagocytosis ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617498 21591 ENSG00000163377
Protein
UniProt ID Q96LR4
Protein name Chemokine-like protein TAFA-4
Protein function Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685). {ECO:0000250|UniProtKB:Q7TPG5, ECO:0000269|PubMed:2510968
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12020 TAFA 50 138 TAFA family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain (PubMed:15028294). Expressed in LPS-stimulated monocytes and macrophages, especially in polarized M1 (PubMed:25109685). {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:25109685}.
Sequence
Sequence length 140
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
15818620
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
15818620
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
15818620
Unknown
Disease term Disease name Evidence References Source
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Mouth Diseases Associate 29663363
Neoplasm Invasiveness Associate 31390052
Neoplasms Associate 26491211, 27415009, 30758084, 30955437, 31390052
Neoplasms Inhibit 30608989, 32022461
Prostatic Neoplasms Associate 26491211
Prostatitis Associate 26491211
Schizotypal Personality Disorder Associate 34743198
Squamous Intraepithelial Lesions Stimulate 30608989
Squamous Intraepithelial Lesions Associate 32022461, 35512257
Urinary Bladder Neoplasms Stimulate 35123558