TAFA4 (TAFA chemokine like family member 4)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
151647
Gene name Gene Name - the full gene name approved by the HGNC.
TAFA chemokine like family member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAFA4
Synonyms (NCBI Gene) Gene synonyms aliases
FAM19A4, TAFA-4
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p14.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
GO:0005615 Component Extracellular space IDA 29453251
GO:0005615 Component Extracellular space IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617498 21591 ENSG00000163377
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q96LR4
Protein name Chemokine-like protein TAFA-4
Protein function Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685). {ECO:0000250|UniProtKB:Q7TPG5, ECO:0000269|PubMed:2510968
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12020 TAFA 50 → 138 TAFA family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain (PubMed:15028294). Expressed in LPS-stimulated monocytes and macrophages, especially in polarized M1 (PubMed:25109685). {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:25109685}.
Sequence
Sequence length 140
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Insomnia Insomnia N/A N/A GWAS
Show/Hide Text Mining Associations (13)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Mouth Diseases Associate 29663363
Neoplasm Invasiveness Associate 31390052
Neoplasms Associate 26491211, 27415009, 30758084, 30955437, 31390052
Neoplasms Inhibit 30608989, 32022461
Prostatic Neoplasms Associate 26491211
Prostatitis Associate 26491211
Schizotypal Personality Disorder Associate 34743198
Squamous Intraepithelial Lesions Stimulate 30608989
Squamous Intraepithelial Lesions Associate 32022461, 35512257
Urinary Bladder Neoplasms Stimulate 35123558