Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1514
Gene name Gene Name - the full gene name approved by the HGNC.	Cathepsin L
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CTSL
Synonyms (NCBI Gene) Gene synonyms aliases	CATL, CTSL1, MEP
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q21.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
JUN	Activation	9038212
SP1	Activation	11742542
SP3	Activation	11742542
STAT1	Unknown	11556541

Show/Hide all(60)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001968	Function	Fibronectin binding	IPI	22952693
GO:0002250	Process	Adaptive immune response	IEP	15196205
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	12809493, 14511383, 22952693
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	28743268
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	8419312
GO:0005515	Function	Protein binding	IPI	12504904, 12809493, 17889653, 22365146, 25416956, 28514442, 32512386, 33774649, 33961781
GO:0005518	Function	Collagen binding	IDA	22952693
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	22952693
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	21326229
GO:0005764	Component	Lysosome	IBA
GO:0005764	Component	Lysosome	IDA	1837142, 15196205, 22365146, 28743268
GO:0005764	Component	Lysosome	IEA
GO:0005771	Component	Multivesicular body	IDA	22365146
GO:0005794	Component	Golgi apparatus	IDA
GO:0005886	Component	Plasma membrane	IDA	22365146
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IDA	8811434, 21326229
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IDA	8811434, 22365146
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016540	Process	Protein autoprocessing	IDA	9468501
GO:0016787	Function	Hydrolase activity	IEA
GO:0019064	Process	Fusion of virus membrane with host plasma membrane	IDA	32855215
GO:0019065	Process	Receptor-mediated endocytosis of virus by host cell	IDA	16081529, 32221306, 32855215
GO:0019882	Process	Antigen processing and presentation	TAS	15196205
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0030574	Process	Collagen catabolic process	IDA	10716919, 22952693
GO:0031012	Component	Extracellular matrix	HDA	25037231
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031638	Process	Zymogen activation	IDA	9468501
GO:0034230	Process	Enkephalin processing	ISS
GO:0036021	Component	Endolysosome lumen	TAS
GO:0039654	Process	Fusion of virus membrane with host endosome membrane	IDA	16081529, 18562523
GO:0042393	Function	Histone binding	IDA	21326229
GO:0042583	Component	Chromaffin granule	IEA
GO:0042583	Component	Chromaffin granule	ISS
GO:0043202	Component	Lysosomal lumen	TAS
GO:0043373	Process	CD4-positive, alpha-beta T cell lineage commitment	ISS
GO:0043394	Function	Proteoglycan binding	IPI	22952693
GO:0046718	Process	Symbiont entry into host cell	IDA	16339146, 18562523, 26953343, 32855215
GO:0048002	Process	Antigen processing and presentation of peptide antigen	ISS
GO:0051603	Process	Proteolysis involved in protein catabolic process	IBA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IDA	22952693
GO:0060309	Process	Elastin catabolic process	ISS
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071682	Component	Endocytic vesicle lumen	TAS
GO:0071888	Process	Macrophage apoptotic process	NAS	18495127
GO:0097067	Process	Cellular response to thyroid hormone stimulus	IEP	21217776
GO:0097655	Function	Serpin family protein binding	IPI	21383048

MIM	HGNC	e!Ensembl
116880	2537	ENSG00000135047

Protein

UniProt ID

P07711

Protein name

Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]

Protein function

Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of

PDB

1CJL , 1CS8 , 1ICF , 1MHW , 2NQD , 2VHS , 2XU1 , 2XU3 , 2XU4 , 2XU5 , 2YJ2 , 2YJ8 , 2YJ9 , 2YJB , 2YJC , 3BC3 , 3H89 , 3H8B , 3H8C , 3HHA , 3HWN , 3IV2 , 3K24 , 3KSE , 3OF8 , 3OF9 , 4AXL , 4AXM , 5F02 , 5I4H , 5MAE , 5MAJ , 5MQY , 6EZP , 6EZX , 6F06 , 6JD0 , 6JD8 , 7QKB , 7QKC , 7QKD , 7W33 , 7W34 , 7Z3T , 7Z58 , 7ZS7 , 7ZVF , 7ZXA , 8A4U , 8A4V , 8A4W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08246	Inhibitor_I29	29 → 88	Cathepsin propeptide inhibitor domain (I29)	Domain
PF00112	Peptidase_C1	114 → 332	Papain family cysteine protease	Domain

Sequence

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Sequence length

333

Interactions

View interactions

	KEGG		Reactome
	Autophagy - animal Lysosome Phagosome Apoptosis Antigen processing and presentation Proteoglycans in cancer Rheumatoid arthritis Fluid shear stress and atherosclerosis		Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

CTSL (cathepsin L)