SLC9B1 (solute carrier family 9 member B1)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
150159
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 9 member B1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC9B1
Synonyms (NCBI Gene) Gene synonyms aliases
NHA1, NHEDC1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q24
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript varian
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane TAS
GO:0006814 Process Sodium ion transport IEA
GO:0007338 Process Single fertilization IEA
GO:0015299 Function Solute:proton antiporter activity IEA
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
611527 24244 ENSG00000164037
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q4ZJI4
Protein name Sodium/hydrogen exchanger 9B1 (Na(+)/H(+) exchanger-like domain-containing protein 1) (NHE domain-containing protein 1) (Sodium/hydrogen exchanger-like domain-containing protein 1) (Solute carrier family 9, subfamily B member 1)
Protein function Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00999 Na_H_Exchanger 96 → 491 Sodium/hydrogen exchanger family Family
Tissue specificity TISSUE SPECIFICITY: Expressed only in the testis. {ECO:0000269|PubMed:16850186}.
Sequence
Sequence length 515
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Stimuli-sensing channels
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)		 30061737, 29892015
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 30285260, 28991256
Wolfram syndrome WOLFRAM SYNDROME 2 rs63749888, rs28937891, rs104893879, rs28937892, rs1578609780, rs1191510461, rs104893880, rs104893881, rs1362648752, rs104893883, rs74315205, rs71524374, rs387906930, rs727503745, rs71530923
View all (25 more)
Show/Hide Unknown Diseases (6)
Unknown
Disease term Disease name Evidence References Source
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation 29892015, 30061737 ClinVar
Atrial Fibrillation Atrial Fibrillation GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Diabetes Diabetes GWAS
Show/Hide Text Mining Associations (2)
Associations from Text Mining
Disease Name Relationship Type References
Diabetes Mellitus Type 1 Associate 34556755
Migraine Disorders Associate 34273149