Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	147912
Gene name	SIX homeobox 5
Gene symbol	SIX5
Synonyms (NCBI Gene)	BOR2DMAHP
Chromosome	19
Chromosome location	19q13.32
Summary	The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a ca

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029180	hsa-miR-26b-5p	Microarray	19088304
MIRT653770	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT653769	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT653768	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT653767	hsa-miR-3657	HITS-CLIP	23824327
MIRT653766	hsa-miR-4669	HITS-CLIP	23824327
MIRT653765	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT653764	hsa-miR-572	HITS-CLIP	23824327
MIRT653763	hsa-miR-718	HITS-CLIP	23824327
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486132	hsa-miR-3147	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23592263
MIRT486150	hsa-miR-4299	PAR-CLIP	23592263
MIRT486149	hsa-miR-548q	PAR-CLIP	23592263
MIRT486148	hsa-miR-4456	PAR-CLIP	23592263
MIRT486146	hsa-miR-7978	PAR-CLIP	23592263
MIRT486147	hsa-miR-3195	PAR-CLIP	23592263
MIRT486145	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486143	hsa-miR-4488	PAR-CLIP	23592263
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT486134	hsa-miR-4447	PAR-CLIP	23592263
MIRT486133	hsa-miR-4472	PAR-CLIP	23592263
MIRT486132	hsa-miR-3147	PAR-CLIP	23592263
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT653770	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT653769	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT653768	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT653767	hsa-miR-3657	HITS-CLIP	23824327
MIRT653766	hsa-miR-4669	HITS-CLIP	23824327
MIRT653765	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT653764	hsa-miR-572	HITS-CLIP	23824327
MIRT653763	hsa-miR-718	HITS-CLIP	23824327
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486132	hsa-miR-3147	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23592263
MIRT486150	hsa-miR-4299	PAR-CLIP	23592263
MIRT486149	hsa-miR-548q	PAR-CLIP	23592263
MIRT486148	hsa-miR-4456	PAR-CLIP	23592263
MIRT486146	hsa-miR-7978	PAR-CLIP	23592263
MIRT486147	hsa-miR-3195	PAR-CLIP	23592263
MIRT486145	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486143	hsa-miR-4488	PAR-CLIP	23592263
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT486134	hsa-miR-4447	PAR-CLIP	23592263
MIRT486133	hsa-miR-4472	PAR-CLIP	23592263
MIRT486132	hsa-miR-3147	PAR-CLIP	23592263
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT2103880	hsa-miR-1226	CLIP-seq
MIRT2103881	hsa-miR-29a	CLIP-seq
MIRT2103882	hsa-miR-29b	CLIP-seq
MIRT2103883	hsa-miR-29c	CLIP-seq
MIRT2103884	hsa-miR-3591-3p	CLIP-seq
MIRT2103885	hsa-miR-4421	CLIP-seq
MIRT2103886	hsa-miR-633	CLIP-seq
MIRT2328038	hsa-miR-1207-5p	CLIP-seq
MIRT2103880	hsa-miR-1226	CLIP-seq
MIRT2328039	hsa-miR-183	CLIP-seq
MIRT2328040	hsa-miR-194	CLIP-seq
MIRT2328041	hsa-miR-2682	CLIP-seq
MIRT2103881	hsa-miR-29a	CLIP-seq
MIRT2103882	hsa-miR-29b	CLIP-seq
MIRT2103883	hsa-miR-29c	CLIP-seq
MIRT2328042	hsa-miR-3150a-3p	CLIP-seq
MIRT2328043	hsa-miR-3175	CLIP-seq
MIRT2328044	hsa-miR-3193	CLIP-seq
MIRT2103884	hsa-miR-3591-3p	CLIP-seq
MIRT2328045	hsa-miR-361-3p	CLIP-seq
MIRT2103885	hsa-miR-4421	CLIP-seq
MIRT2328046	hsa-miR-4446-3p	CLIP-seq
MIRT2328047	hsa-miR-449c	CLIP-seq
MIRT2328048	hsa-miR-4504	CLIP-seq
MIRT2328049	hsa-miR-4514	CLIP-seq
MIRT2328050	hsa-miR-4645-5p	CLIP-seq
MIRT2328051	hsa-miR-4673	CLIP-seq
MIRT2328052	hsa-miR-4675	CLIP-seq
MIRT2328053	hsa-miR-4692	CLIP-seq
MIRT2328054	hsa-miR-4721	CLIP-seq
MIRT2328055	hsa-miR-4728-5p	CLIP-seq
MIRT2328056	hsa-miR-4736	CLIP-seq
MIRT2328057	hsa-miR-4741	CLIP-seq
MIRT2328058	hsa-miR-4763-3p	CLIP-seq
MIRT2328059	hsa-miR-542-3p	CLIP-seq
MIRT2328060	hsa-miR-549	CLIP-seq
MIRT2103886	hsa-miR-633	CLIP-seq
MIRT2328061	hsa-miR-758	CLIP-seq
MIRT2328062	hsa-miR-939	CLIP-seq
MIRT2328054	hsa-miR-4721	CLIP-seq
MIRT2459431	hsa-miR-3667-5p	CLIP-seq
MIRT2459432	hsa-miR-4286	CLIP-seq
MIRT2459433	hsa-miR-7	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
CTCF	Unknown	11479593

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0002088	Process	Lens development in camera-type eye	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16713569
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007286	Process	Spermatid development	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0160024	Process	Leydig cell proliferation	IEA
GO:1902723	Process	Negative regulation of skeletal muscle satellite cell proliferation	IEA

MIM	HGNC	e!Ensembl
600963	10891	ENSG00000177045

Q8N196

Protein name

Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5)

Protein function

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16878	SIX1_SD	86 → 196	Transcriptional regulator, SIX1, N-terminal SD domain	Domain
PF00046	Homeodomain	206 → 258	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera. {ECO:0000269|PubMed:9949207}.

Sequence

MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG
AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL
RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL
GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL
SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA
QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL
LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE
VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP
TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL
LANPVSGSPIVTGVALQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL
PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA
AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA
EAKVLTQLQSVPVEEPLEL

Sequence length

739

Interactions

View interactions

121

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Branchiootorenal syndrome 2	Pathogenic	rs80356463	RCV000009131

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
SIX5-related disorder	Conflicting classifications of pathogenicity; Likely benign; Uncertain significance; Benign	rs752238132, rs372106524, rs372293937, rs760311721, rs747106145, rs764189203, rs751067755, rs899825113, rs753341384, rs80356462, rs1969057144, rs1424982690, rs372239517, rs1360502644, rs2513605497 View all (23 more)	RCV003948714 RCV003892836 RCV003892837 RCV003895903 RCV003953852 RCV003916494 RCV004753578 RCV003404002 RCV004753652 RCV004752693 RCV003404260 RCV003406097 RCV003417060 RCV003402402 RCV003397601 RCV003410472 RCV003414313 RCV003404409 RCV003901311 RCV003939186 RCV003956549 RCV003949064 RCV003896719 RCV003974244 RCV003899578 RCV003939458 RCV003954547 RCV003982086 RCV003915424 RCV003962753 RCV003947940 RCV003908121 RCV003940393 RCV003920502 RCV003908398 RCV003958258 RCV003933057 RCV003960388

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adrenal Insufficiency	Associate	26190529
Branchio Oto Renal Syndrome	Associate	17357085, 19215039, 23840632, 35545373
Cakut	Associate	24429398
Coronary Artery Disease	Associate	27864399
Hearing Loss	Associate	35709191
Myotonic Dystrophy	Associate	26190529, 28211918
Nonsyndromic Deafness	Associate	35709191
Obesity	Associate	26449484

SIX5 (SIX homeobox 5)