CST4 (cystatin S)

Gene

• Entrez ID: 1472
• Gene name: Cystatin S
• Gene symbol: CST4
• Synonyms (NCBI Gene): -
• Chromosome: 20
• Chromosome location: 20p11.21
• Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017577	hsa-miR-335-5p	Microarray	18185580
MIRT736215	hsa-miR-6715b-5p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC)	34194498
MIRT913343	hsa-miR-3065-5p	CLIP-seq
MIRT913344	hsa-miR-3173-5p	CLIP-seq
MIRT913345	hsa-miR-339-3p	CLIP-seq
MIRT913346	hsa-miR-370	CLIP-seq
MIRT913347	hsa-miR-4663	CLIP-seq
MIRT2206619	hsa-miR-134	CLIP-seq
MIRT2206620	hsa-miR-139-5p	CLIP-seq
MIRT2206621	hsa-miR-3118	CLIP-seq
MIRT2206622	hsa-miR-3164	CLIP-seq
MIRT2206623	hsa-miR-4300	CLIP-seq
MIRT2206624	hsa-miR-4447	CLIP-seq
MIRT2206625	hsa-miR-4472	CLIP-seq
MIRT2206626	hsa-miR-4488	CLIP-seq
MIRT2206627	hsa-miR-455-3p	CLIP-seq
MIRT2206628	hsa-miR-4651	CLIP-seq
MIRT2206629	hsa-miR-4685-5p	CLIP-seq
MIRT2206630	hsa-miR-4697-5p	CLIP-seq
MIRT2206631	hsa-miR-608	CLIP-seq
MIRT2206632	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001580	Process	Detection of chemical stimulus involved in sensory perception of bitter taste	IDA	24248522
GO:0001895	Process	Retina homeostasis	HEP	23580065
GO:0004869	Function	Cysteine-type endopeptidase inhibitor activity	IDA	3488317, 8999869
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005615	Component	Extracellular space	HDA	22664934, 23580065
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	3488317, 24248522
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0045861	Process	Negative regulation of proteolysis	IDA	3488317
GO:0070062	Component	Extracellular exosome	HDA	19199708

Other IDs

• MIM: 123857
• HGNC: 2476
• e!Ensembl: ENSG00000101441

Protein

• UniProt ID: P01036
• Protein name: Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1)
• Protein function: This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00031	Cystatin	32 → 127	Cystatin domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269|PubMed:20189825}.
• Sequence:

  MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATE
  DEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSF
  EIYEVPWEDRMSLVNSRCQEA

• Sequence length: 141

Pathways

KEGG:

Salivary secretion

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Associations from Text Mining
Disease Name	Relationship Type	References
Asthma	Stimulate	28933920
Colorectal Neoplasms	Stimulate	37122229
Dental Caries	Associate	18804197
Distal myopathy Nonaka type	Stimulate	37797812
Down Syndrome	Inhibit	23533003
Dry Eye Syndromes	Inhibit	34012227
Infections	Inhibit	18385783
Inflammation	Associate	35740863
Keratoconus	Associate	21701529
Keratoconus	Inhibit	24194634
Mouth Diseases	Associate	18804197
Neoplasms	Inhibit	33001337
Neoplasms	Associate	37978366
Phobic Disorders	Associate	36776870
Respiratory Sounds	Associate	36776870
Sjogren's Syndrome	Associate	35740863
Urinary Bladder Neoplasms	Associate	35393513
Vaginosis Bacterial	Associate	26081632