KIF18B (kinesin family member 18B)

Gene

• Entrez ID: 146909
• Gene name: Kinesin family member 18B
• Gene symbol: KIF18B
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049401	hsa-miR-92a-3p	CLASH	23622248
MIRT048234	hsa-miR-196a-5p	CLASH	23622248
MIRT672728	hsa-miR-5693	HITS-CLIP	23824327
MIRT672727	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT672726	hsa-miR-6089	HITS-CLIP	23824327
MIRT672725	hsa-miR-4284	HITS-CLIP	23824327
MIRT672724	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672723	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT503265	hsa-miR-6165	PAR-CLIP	23446348
MIRT503264	hsa-miR-4690-5p	PAR-CLIP	23446348
MIRT503263	hsa-miR-6510-5p	PAR-CLIP	23446348
MIRT503262	hsa-miR-2392	PAR-CLIP	23446348
MIRT503261	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT503260	hsa-miR-4667-5p	PAR-CLIP	23446348
MIRT503259	hsa-miR-4700-5p	PAR-CLIP	23446348
MIRT503258	hsa-miR-8089	PAR-CLIP	23446348
MIRT503257	hsa-miR-637	PAR-CLIP	23446348
MIRT503256	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT503255	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT503254	hsa-miR-3134	PAR-CLIP	23446348
MIRT503253	hsa-miR-4764-5p	PAR-CLIP	23446348
MIRT503252	hsa-miR-6869-5p	PAR-CLIP	23446348
MIRT503251	hsa-miR-1231	PAR-CLIP	23446348
MIRT496576	hsa-miR-1273g-3p	PAR-CLIP	22291592
MIRT496575	hsa-miR-4793-3p	PAR-CLIP	22291592
MIRT496574	hsa-miR-6788-3p	PAR-CLIP	22291592
MIRT496573	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT672728	hsa-miR-5693	HITS-CLIP	23824327
MIRT672727	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT672726	hsa-miR-6089	HITS-CLIP	23824327
MIRT672725	hsa-miR-4284	HITS-CLIP	23824327
MIRT672724	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672723	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT503265	hsa-miR-6165	PAR-CLIP	23446348
MIRT503264	hsa-miR-4690-5p	PAR-CLIP	23446348
MIRT503263	hsa-miR-6510-5p	PAR-CLIP	23446348
MIRT503262	hsa-miR-2392	PAR-CLIP	23446348
MIRT503261	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT503260	hsa-miR-4667-5p	PAR-CLIP	23446348
MIRT503259	hsa-miR-4700-5p	PAR-CLIP	23446348
MIRT503258	hsa-miR-8089	PAR-CLIP	23446348
MIRT503257	hsa-miR-637	PAR-CLIP	23446348
MIRT503256	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT503255	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT503254	hsa-miR-3134	PAR-CLIP	23446348
MIRT503253	hsa-miR-4764-5p	PAR-CLIP	23446348
MIRT503252	hsa-miR-6869-5p	PAR-CLIP	23446348
MIRT503251	hsa-miR-1231	PAR-CLIP	23446348
MIRT496576	hsa-miR-1273g-3p	PAR-CLIP	22291592
MIRT496575	hsa-miR-4793-3p	PAR-CLIP	22291592
MIRT496574	hsa-miR-6788-3p	PAR-CLIP	22291592
MIRT496573	hsa-miR-6807-5p	PAR-CLIP	22291592

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	IBA
GO:0000166	Function	Nucleotide binding	IEA
GO:0000235	Component	Astral microtubule	IDA	21820309
GO:0000278	Process	Mitotic cell cycle	IDA	20600703
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0003774	Function	Cytoskeletal motor activity	IDA	21820309
GO:0003774	Function	Cytoskeletal motor activity	IEA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005515	Function	Protein binding	IPI	21820309
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20600703
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	20600703
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IBA
GO:0005874	Component	Microtubule	IEA
GO:0005876	Component	Spindle microtubule	IEA
GO:0007018	Process	Microtubule-based movement	IBA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0007019	Process	Microtubule depolymerization	IBA
GO:0007019	Process	Microtubule depolymerization	IDA	21820309
GO:0007019	Process	Microtubule depolymerization	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008574	Function	Plus-end-directed microtubule motor activity	IBA
GO:0016604	Component	Nuclear body	IDA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0019894	Function	Kinesin binding	IPI	21820309
GO:0035371	Component	Microtubule plus-end	IDA	21820309
GO:0051301	Process	Cell division	IEA
GO:0051302	Process	Regulation of cell division	IDA	20600703
GO:0061673	Component	Mitotic spindle astral microtubule	IBA
GO:1990023	Component	Mitotic spindle midzone	IBA
GO:1990752	Component	Microtubule end	IDA

Other IDs

• MIM: 614570
• HGNC: 27102
• e!Ensembl: ENSG00000186185

Protein

• UniProt ID: Q86Y91
• Protein name: Kinesin-like protein KIF18B
• Protein function: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	13 → 351	Kinesin motor domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Shows a prominent expression in the amygdala. {ECO:0000269|PubMed:20600703}.
• Sequence:

  MAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDG
  PKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTML
  GREGDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPD
  KGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPG
  LTQAVQVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKTH
  VPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVT
  SLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPPEHQPCTPEL
  PAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEGPAEEVPTQMPEQNPTHALPES
  PRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQYSLLQAANLLTPDMITEFETLQ
  QLVQEEKIEPGAEALRTSGLARGAPLAQELCSESIPVPSPLCPEPPGYTGPVTRTMARRL
  SGPLHTLGIPPGPNCTPAQGSRWPMEKKRRRPSALEADSPMAPKRGTKRQRQSFLPCLRR
  GSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIKSRVPLGPSAMQNCSTPLALPTRDL
  NATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIPRAPVPLFTMKGPKPTSSLPGTS
  ACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSNRRNGKDLIRVGR
  ALSAGNGVTKVS

• Sequence length: 852

Pathways

KEGG:

Motor proteins

Reactome:

COPI-dependent Golgi-to-ER retrograde traffic
Kinesins