RTN4RL1 (reticulon 4 receptor like 1)

Gene

• Entrez ID: 146760
• Gene name: Reticulon 4 receptor like 1
• Gene symbol: RTN4RL1
• Synonyms (NCBI Gene): NGRH2, NgR3
• Chromosome: 17
• Chromosome location: 17p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT510838	hsa-miR-5586-3p	HITS-CLIP	21572407
MIRT510837	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510835	hsa-miR-3668	HITS-CLIP	21572407
MIRT510836	hsa-miR-7852-3p	HITS-CLIP	21572407
MIRT510834	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT510833	hsa-miR-6832-5p	HITS-CLIP	21572407
MIRT510832	hsa-miR-4732-5p	HITS-CLIP	21572407
MIRT510831	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510830	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510829	hsa-miR-6831-5p	HITS-CLIP	21572407
MIRT510838	hsa-miR-5586-3p	HITS-CLIP	21572407
MIRT510837	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510835	hsa-miR-3668	HITS-CLIP	21572407
MIRT510836	hsa-miR-7852-3p	HITS-CLIP	21572407
MIRT510833	hsa-miR-6832-5p	HITS-CLIP	21572407
MIRT510832	hsa-miR-4732-5p	HITS-CLIP	21572407
MIRT510831	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510830	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510829	hsa-miR-6831-5p	HITS-CLIP	21572407
MIRT510838	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT510837	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT510835	hsa-miR-3668	HITS-CLIP	23313552
MIRT510836	hsa-miR-7852-3p	HITS-CLIP	23313552
MIRT510834	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT510833	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT510832	hsa-miR-4732-5p	HITS-CLIP	23313552
MIRT510831	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT510830	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT510829	hsa-miR-6831-5p	HITS-CLIP	23313552
MIRT510838	hsa-miR-5586-3p	PAR-CLIP	21572407
MIRT510837	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510835	hsa-miR-3668	PAR-CLIP	21572407
MIRT510836	hsa-miR-7852-3p	PAR-CLIP	21572407
MIRT510834	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT510833	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT510832	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT510831	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510830	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT510829	hsa-miR-6831-5p	PAR-CLIP	21572407
MIRT510838	hsa-miR-5586-3p	PAR-CLIP	23446348
MIRT510837	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510835	hsa-miR-3668	PAR-CLIP	23446348
MIRT510836	hsa-miR-7852-3p	PAR-CLIP	23446348
MIRT510834	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT510833	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT510832	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT521268	hsa-miR-1257	PAR-CLIP	23446348
MIRT521267	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT510831	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521266	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT510830	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510829	hsa-miR-6831-5p	PAR-CLIP	23446348
MIRT510838	hsa-miR-5586-3p	PAR-CLIP	23446348
MIRT510837	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510835	hsa-miR-3668	PAR-CLIP	23446348
MIRT510836	hsa-miR-7852-3p	PAR-CLIP	23446348
MIRT510834	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT510833	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT510832	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT510831	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510830	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510829	hsa-miR-6831-5p	PAR-CLIP	23446348
MIRT510838	hsa-miR-5586-3p	HITS-CLIP	21572407
MIRT510837	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510835	hsa-miR-3668	HITS-CLIP	21572407
MIRT510836	hsa-miR-7852-3p	HITS-CLIP	21572407
MIRT510834	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT510833	hsa-miR-6832-5p	HITS-CLIP	21572407
MIRT510832	hsa-miR-4732-5p	HITS-CLIP	21572407
MIRT510831	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510830	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510829	hsa-miR-6831-5p	HITS-CLIP	21572407
MIRT510838	hsa-miR-5586-3p	HITS-CLIP	21572407
MIRT510837	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510835	hsa-miR-3668	HITS-CLIP	21572407
MIRT510836	hsa-miR-7852-3p	HITS-CLIP	21572407
MIRT510833	hsa-miR-6832-5p	HITS-CLIP	21572407
MIRT510832	hsa-miR-4732-5p	HITS-CLIP	21572407
MIRT510831	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510830	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510829	hsa-miR-6831-5p	HITS-CLIP	21572407
MIRT510838	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT510837	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT510835	hsa-miR-3668	HITS-CLIP	23313552
MIRT510836	hsa-miR-7852-3p	HITS-CLIP	23313552
MIRT510834	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT510833	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT510832	hsa-miR-4732-5p	HITS-CLIP	23313552
MIRT510831	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT510830	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT510829	hsa-miR-6831-5p	HITS-CLIP	23313552
MIRT510838	hsa-miR-5586-3p	PAR-CLIP	21572407
MIRT510837	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510835	hsa-miR-3668	PAR-CLIP	21572407
MIRT510836	hsa-miR-7852-3p	PAR-CLIP	21572407
MIRT510834	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT510833	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT510832	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT510831	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510830	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT510829	hsa-miR-6831-5p	PAR-CLIP	21572407
MIRT510838	hsa-miR-5586-3p	PAR-CLIP	23446348
MIRT510837	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510835	hsa-miR-3668	PAR-CLIP	23446348
MIRT510836	hsa-miR-7852-3p	PAR-CLIP	23446348
MIRT510834	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT510833	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT510832	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT521268	hsa-miR-1257	PAR-CLIP	23446348
MIRT521267	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT510831	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521266	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT510830	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510829	hsa-miR-6831-5p	PAR-CLIP	23446348
MIRT510838	hsa-miR-5586-3p	PAR-CLIP	23446348
MIRT510837	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510835	hsa-miR-3668	PAR-CLIP	23446348
MIRT510836	hsa-miR-7852-3p	PAR-CLIP	23446348
MIRT510834	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT510833	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT510832	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT510831	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510830	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510829	hsa-miR-6831-5p	PAR-CLIP	23446348
MIRT1322285	hsa-miR-1321	CLIP-seq
MIRT1322286	hsa-miR-133a	CLIP-seq
MIRT1322287	hsa-miR-133b	CLIP-seq
MIRT1322288	hsa-miR-136	CLIP-seq
MIRT1322289	hsa-miR-191	CLIP-seq
MIRT1322290	hsa-miR-19a	CLIP-seq
MIRT1322291	hsa-miR-19b	CLIP-seq
MIRT1322292	hsa-miR-2113	CLIP-seq
MIRT1322293	hsa-miR-28-5p	CLIP-seq
MIRT1322294	hsa-miR-3121-5p	CLIP-seq
MIRT1322295	hsa-miR-3124-3p	CLIP-seq
MIRT1322296	hsa-miR-3127-3p	CLIP-seq
MIRT1322297	hsa-miR-3139	CLIP-seq
MIRT1322298	hsa-miR-3157-5p	CLIP-seq
MIRT1322299	hsa-miR-3168	CLIP-seq
MIRT1322300	hsa-miR-3184	CLIP-seq
MIRT1322301	hsa-miR-3192	CLIP-seq
MIRT1322302	hsa-miR-3197	CLIP-seq
MIRT1322303	hsa-miR-330-3p	CLIP-seq
MIRT1322304	hsa-miR-331-5p	CLIP-seq
MIRT1322305	hsa-miR-34a	CLIP-seq
MIRT1322306	hsa-miR-34c-5p	CLIP-seq
MIRT1322307	hsa-miR-3609	CLIP-seq
MIRT1322308	hsa-miR-361-3p	CLIP-seq
MIRT1322309	hsa-miR-3667-3p	CLIP-seq
MIRT1322310	hsa-miR-3682-3p	CLIP-seq
MIRT1322311	hsa-miR-3689a-3p	CLIP-seq
MIRT1322312	hsa-miR-3689c	CLIP-seq
MIRT1322313	hsa-miR-3913-3p	CLIP-seq
MIRT1322314	hsa-miR-423-5p	CLIP-seq
MIRT1322315	hsa-miR-4281	CLIP-seq
MIRT1322316	hsa-miR-4292	CLIP-seq
MIRT1322317	hsa-miR-4317	CLIP-seq
MIRT1322318	hsa-miR-4324	CLIP-seq
MIRT1322319	hsa-miR-4329	CLIP-seq
MIRT1322320	hsa-miR-4419a	CLIP-seq
MIRT1322321	hsa-miR-4464	CLIP-seq
MIRT1322322	hsa-miR-4481	CLIP-seq
MIRT1322323	hsa-miR-449a	CLIP-seq
MIRT1322324	hsa-miR-449b	CLIP-seq
MIRT1322325	hsa-miR-4502	CLIP-seq
MIRT1322326	hsa-miR-4505	CLIP-seq
MIRT1322327	hsa-miR-4510	CLIP-seq
MIRT1322328	hsa-miR-4522	CLIP-seq
MIRT1322329	hsa-miR-4640-3p	CLIP-seq
MIRT1322330	hsa-miR-4640-5p	CLIP-seq
MIRT1322331	hsa-miR-4656	CLIP-seq
MIRT1322332	hsa-miR-4670-3p	CLIP-seq
MIRT1322333	hsa-miR-4712-3p	CLIP-seq
MIRT1322334	hsa-miR-4726-5p	CLIP-seq
MIRT1322335	hsa-miR-4728-5p	CLIP-seq
MIRT1322336	hsa-miR-4731-5p	CLIP-seq
MIRT1322337	hsa-miR-4739	CLIP-seq
MIRT1322338	hsa-miR-4745-5p	CLIP-seq
MIRT1322339	hsa-miR-4748	CLIP-seq
MIRT1322340	hsa-miR-4756-5p	CLIP-seq
MIRT1322341	hsa-miR-4777-5p	CLIP-seq
MIRT1322342	hsa-miR-493	CLIP-seq
MIRT1322343	hsa-miR-512-3p	CLIP-seq
MIRT1322344	hsa-miR-515-5p	CLIP-seq
MIRT1322345	hsa-miR-518a-5p	CLIP-seq
MIRT1322346	hsa-miR-518d-5p	CLIP-seq
MIRT1322347	hsa-miR-519b-5p	CLIP-seq
MIRT1322348	hsa-miR-519c-5p	CLIP-seq
MIRT1322349	hsa-miR-520c-5p	CLIP-seq
MIRT1322350	hsa-miR-520g	CLIP-seq
MIRT1322351	hsa-miR-520h	CLIP-seq
MIRT1322352	hsa-miR-526a	CLIP-seq
MIRT1322353	hsa-miR-527	CLIP-seq
MIRT1322354	hsa-miR-548ah	CLIP-seq
MIRT1322355	hsa-miR-582-5p	CLIP-seq
MIRT1322356	hsa-miR-628-5p	CLIP-seq
MIRT1322357	hsa-miR-708	CLIP-seq
MIRT1322358	hsa-miR-720	CLIP-seq
MIRT1322359	hsa-miR-873	CLIP-seq
MIRT1322360	hsa-miR-9	CLIP-seq
MIRT2095636	hsa-miR-1202	CLIP-seq
MIRT2095637	hsa-miR-1270	CLIP-seq
MIRT2095638	hsa-miR-182	CLIP-seq
MIRT2095639	hsa-miR-31	CLIP-seq
MIRT2095640	hsa-miR-3122	CLIP-seq
MIRT2095641	hsa-miR-3130-3p	CLIP-seq
MIRT2095642	hsa-miR-3163	CLIP-seq
MIRT2095643	hsa-miR-3189-5p	CLIP-seq
MIRT2095644	hsa-miR-3200-3p	CLIP-seq
MIRT2095645	hsa-miR-340	CLIP-seq
MIRT2095646	hsa-miR-3620	CLIP-seq
MIRT2095647	hsa-miR-3913-5p	CLIP-seq
MIRT2095648	hsa-miR-3922-5p	CLIP-seq
MIRT2095649	hsa-miR-3972	CLIP-seq
MIRT2095650	hsa-miR-432	CLIP-seq
MIRT2095651	hsa-miR-4320	CLIP-seq
MIRT2095652	hsa-miR-4438	CLIP-seq
MIRT2095653	hsa-miR-450b-3p	CLIP-seq
MIRT2095654	hsa-miR-4530	CLIP-seq
MIRT2095655	hsa-miR-4531	CLIP-seq
MIRT2095656	hsa-miR-4535	CLIP-seq
MIRT2095657	hsa-miR-4708-3p	CLIP-seq
MIRT2095658	hsa-miR-4753-5p	CLIP-seq
MIRT2095659	hsa-miR-4758-3p	CLIP-seq
MIRT2095660	hsa-miR-4776-5p	CLIP-seq
MIRT2095661	hsa-miR-4780	CLIP-seq
MIRT2095662	hsa-miR-620	CLIP-seq
MIRT2095663	hsa-miR-623	CLIP-seq
MIRT2095664	hsa-miR-769-3p	CLIP-seq
MIRT2320095	hsa-miR-1207-5p	CLIP-seq
MIRT2320096	hsa-miR-1262	CLIP-seq
MIRT2320097	hsa-miR-1302	CLIP-seq
MIRT1322290	hsa-miR-19a	CLIP-seq
MIRT1322291	hsa-miR-19b	CLIP-seq
MIRT1322292	hsa-miR-2113	CLIP-seq
MIRT2095641	hsa-miR-3130-3p	CLIP-seq
MIRT2320098	hsa-miR-3183	CLIP-seq
MIRT2320099	hsa-miR-326	CLIP-seq
MIRT1322303	hsa-miR-330-3p	CLIP-seq
MIRT2320100	hsa-miR-330-5p	CLIP-seq
MIRT2095646	hsa-miR-3620	CLIP-seq
MIRT2320101	hsa-miR-3677-3p	CLIP-seq
MIRT2320102	hsa-miR-374a	CLIP-seq
MIRT2320103	hsa-miR-374b	CLIP-seq
MIRT2320104	hsa-miR-377	CLIP-seq
MIRT2320105	hsa-miR-4258	CLIP-seq
MIRT2320106	hsa-miR-4298	CLIP-seq
MIRT2095650	hsa-miR-432	CLIP-seq
MIRT2320107	hsa-miR-4450	CLIP-seq
MIRT1322321	hsa-miR-4464	CLIP-seq
MIRT2320108	hsa-miR-4494	CLIP-seq
MIRT2095654	hsa-miR-4530	CLIP-seq
MIRT2320109	hsa-miR-4701-3p	CLIP-seq
MIRT2320110	hsa-miR-4701-5p	CLIP-seq
MIRT2320111	hsa-miR-4717-3p	CLIP-seq
MIRT2320112	hsa-miR-4723-3p	CLIP-seq
MIRT2320113	hsa-miR-4736	CLIP-seq
MIRT2320114	hsa-miR-4740-3p	CLIP-seq
MIRT1322339	hsa-miR-4748	CLIP-seq
MIRT2320115	hsa-miR-4763-3p	CLIP-seq
MIRT2320116	hsa-miR-4763-5p	CLIP-seq
MIRT2320117	hsa-miR-4792	CLIP-seq
MIRT2320118	hsa-miR-500a	CLIP-seq
MIRT1322345	hsa-miR-518a-5p	CLIP-seq
MIRT1322353	hsa-miR-527	CLIP-seq
MIRT2320119	hsa-miR-579	CLIP-seq
MIRT1322355	hsa-miR-582-5p	CLIP-seq
MIRT2320120	hsa-miR-588	CLIP-seq
MIRT2320121	hsa-miR-615-3p	CLIP-seq
MIRT2320122	hsa-miR-629	CLIP-seq
MIRT1322360	hsa-miR-9	CLIP-seq
MIRT2095636	hsa-miR-1202	CLIP-seq
MIRT2095649	hsa-miR-3972	CLIP-seq
MIRT2458693	hsa-miR-1281	CLIP-seq
MIRT2458694	hsa-miR-4469	CLIP-seq
MIRT2458695	hsa-miR-4639-5p	CLIP-seq
MIRT2095658	hsa-miR-4753-5p	CLIP-seq
MIRT2458693	hsa-miR-1281	CLIP-seq
MIRT2458694	hsa-miR-4469	CLIP-seq
MIRT2458695	hsa-miR-4639-5p	CLIP-seq
MIRT2095658	hsa-miR-4753-5p	CLIP-seq
MIRT2458693	hsa-miR-1281	CLIP-seq
MIRT2458694	hsa-miR-4469	CLIP-seq
MIRT2458695	hsa-miR-4639-5p	CLIP-seq
MIRT2095658	hsa-miR-4753-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12694398
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0008201	Function	Heparin binding	IEA
GO:0008201	Function	Heparin binding	ISS
GO:0009986	Component	Cell surface	IDA	20463223
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0010977	Process	Negative regulation of neuron projection development	ISS
GO:0016020	Component	Membrane	IEA
GO:0022038	Process	Corpus callosum development	IEA
GO:0031103	Process	Axon regeneration	TAS	14664809
GO:0035374	Function	Chondroitin sulfate binding	IEA
GO:0035374	Function	Chondroitin sulfate binding	ISS
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IDA	12694398
GO:0042995	Component	Cell projection	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0048681	Process	Negative regulation of axon regeneration	IEA
GO:0048681	Process	Negative regulation of axon regeneration	ISS
GO:0051965	Process	Positive regulation of synapse assembly	IBA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0098552	Component	Side of membrane	IEA

Other IDs

• MIM: 610461
• HGNC: 21329
• e!Ensembl: ENSG00000185924

Protein

• UniProt ID: Q86UN2
• Protein name: Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3)
• Protein function: Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	57 → 111	Leucine rich repeat	Repeat
  PF13855	LRR_8	76 → 137	Leucine rich repeat	Repeat
  PF13855	LRR_8	100 → 161	Leucine rich repeat	Repeat
  PF13855	LRR_8	126 → 185	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:14664809}.
• Sequence:

  MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF
  LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPET
  FQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFL
  HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGEC
  LAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAED
  FRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPR
  NRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQAS
  SASSLGASLLAWTLGLAVTLR

• Sequence length: 441

Pathways

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins