Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
146760
Gene name Gene Name - the full gene name approved by the HGNC.
Reticulon 4 receptor like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RTN4RL1
Synonyms (NCBI Gene) Gene synonyms aliases
NGRH2, NgR3
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT510838 hsa-miR-5586-3p HITS-CLIP 21572407
MIRT510837 hsa-miR-5011-5p HITS-CLIP 21572407
MIRT510835 hsa-miR-3668 HITS-CLIP 21572407
MIRT510836 hsa-miR-7852-3p HITS-CLIP 21572407
MIRT510834 hsa-miR-574-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0008201 Function Heparin binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610461 21329 ENSG00000185924
Protein
UniProt ID Q86UN2
Protein name Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3)
Protein function Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 57 111 Leucine rich repeat Repeat
PF13855 LRR_8 76 137 Leucine rich repeat Repeat
PF13855 LRR_8 100 161 Leucine rich repeat Repeat
PF13855 LRR_8 126 185 Leucine rich repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:14664809}.
Sequence
MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF
LQNNRIGLLQPGHFS
PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPET
FQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHI
EYLQDDIFVDLVNLSHLFL
HGNKL
WSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGEC
LAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAED
FRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPR
NRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQAS
SASSLGASLLAWTLGLAVTLR
Sequence length 441
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
29621232
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Diabetes Diabetes GWAS
Metabolic Syndrome Metabolic Syndrome GWAS