HAPLN3 (hyaluronan and proteoglycan link protein 3)

Gene

• Entrez ID: 145864
• Gene name: Hyaluronan and proteoglycan link protein 3
• Gene symbol: HAPLN3
• Synonyms (NCBI Gene): EXLD1, HsT19883
• Chromosome: 15
• Chromosome location: 15q26.1
• Summary: This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1040720	hsa-miR-103b	CLIP-seq
MIRT1040721	hsa-miR-1228	CLIP-seq
MIRT1040722	hsa-miR-2682	CLIP-seq
MIRT1040723	hsa-miR-296-5p	CLIP-seq
MIRT1040724	hsa-miR-29a	CLIP-seq
MIRT1040725	hsa-miR-29b	CLIP-seq
MIRT1040726	hsa-miR-29c	CLIP-seq
MIRT1040727	hsa-miR-329	CLIP-seq
MIRT1040728	hsa-miR-3616-3p	CLIP-seq
MIRT1040729	hsa-miR-3622a-3p	CLIP-seq
MIRT1040730	hsa-miR-3622b-3p	CLIP-seq
MIRT1040731	hsa-miR-362-3p	CLIP-seq
MIRT1040732	hsa-miR-3714	CLIP-seq
MIRT1040733	hsa-miR-3941	CLIP-seq
MIRT1040734	hsa-miR-3973	CLIP-seq
MIRT1040735	hsa-miR-4286	CLIP-seq
MIRT1040736	hsa-miR-449c	CLIP-seq
MIRT1040737	hsa-miR-4721	CLIP-seq
MIRT1040738	hsa-miR-4729	CLIP-seq
MIRT1040739	hsa-miR-4749-3p	CLIP-seq
MIRT1040740	hsa-miR-544b	CLIP-seq
MIRT1040741	hsa-miR-548k	CLIP-seq
MIRT1040742	hsa-miR-603	CLIP-seq
MIRT1040743	hsa-miR-767-5p	CLIP-seq
MIRT1040724	hsa-miR-29a	CLIP-seq
MIRT1040725	hsa-miR-29b	CLIP-seq
MIRT1040726	hsa-miR-29c	CLIP-seq
MIRT1040734	hsa-miR-3973	CLIP-seq
MIRT1040738	hsa-miR-4729	CLIP-seq
MIRT1040739	hsa-miR-4749-3p	CLIP-seq
MIRT1040741	hsa-miR-548k	CLIP-seq
MIRT1040743	hsa-miR-767-5p	CLIP-seq
MIRT2544476	hsa-miR-4261	CLIP-seq
MIRT2544477	hsa-miR-4768-3p	CLIP-seq
MIRT1040723	hsa-miR-296-5p	CLIP-seq
MIRT1040728	hsa-miR-3616-3p	CLIP-seq
MIRT1040729	hsa-miR-3622a-3p	CLIP-seq
MIRT1040730	hsa-miR-3622b-3p	CLIP-seq
MIRT2544476	hsa-miR-4261	CLIP-seq
MIRT1040735	hsa-miR-4286	CLIP-seq
MIRT1040737	hsa-miR-4721	CLIP-seq
MIRT1040739	hsa-miR-4749-3p	CLIP-seq
MIRT2544477	hsa-miR-4768-3p	CLIP-seq
MIRT1040740	hsa-miR-544b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0045202	Component	Synapse	IBA
GO:0072534	Component	Perineuronal net	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q96S86
• Protein name: Hyaluronan and proteoglycan link protein 3
• Protein function: May function in hyaluronic acid binding.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	52 → 163	Immunoglobulin V-set domain	Domain
  PF00193	Xlink	166 → 260	Extracellular link domain	Domain
  PF00193	Xlink	267 → 357	Extracellular link domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with highest levels in spleen and placenta. {ECO:0000269|PubMed:12663660}.
• Sequence:

  MGLLLLVPLLLLPGSYGLPFYNGFYYSNSANDQNLGNGHGKDLLNGVKLVVETPEETLFT
  YQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVH
  LRQDKEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNGRYQFN
  FHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAP
  GVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIAKVGQLF
  AAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPDPQSRLYGVYCYRQH
  

• Sequence length: 360