Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	145864
Gene name Gene Name - the full gene name approved by the HGNC.	Hyaluronan and proteoglycan link protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HAPLN3
Synonyms (NCBI Gene) Gene synonyms aliases	EXLD1, HsT19883
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q26.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]

Show/Hide all(44)

miRTarBase ID	miRNA	Experiments
MIRT1040720	hsa-miR-103b	CLIP-seq
MIRT1040721	hsa-miR-1228	CLIP-seq
MIRT1040722	hsa-miR-2682	CLIP-seq
MIRT1040723	hsa-miR-296-5p	CLIP-seq
MIRT1040724	hsa-miR-29a	CLIP-seq
MIRT1040725	hsa-miR-29b	CLIP-seq
MIRT1040726	hsa-miR-29c	CLIP-seq
MIRT1040727	hsa-miR-329	CLIP-seq
MIRT1040728	hsa-miR-3616-3p	CLIP-seq
MIRT1040729	hsa-miR-3622a-3p	CLIP-seq
MIRT1040730	hsa-miR-3622b-3p	CLIP-seq
MIRT1040731	hsa-miR-362-3p	CLIP-seq
MIRT1040732	hsa-miR-3714	CLIP-seq
MIRT1040733	hsa-miR-3941	CLIP-seq
MIRT1040734	hsa-miR-3973	CLIP-seq
MIRT1040735	hsa-miR-4286	CLIP-seq
MIRT1040736	hsa-miR-449c	CLIP-seq
MIRT1040737	hsa-miR-4721	CLIP-seq
MIRT1040738	hsa-miR-4729	CLIP-seq
MIRT1040739	hsa-miR-4749-3p	CLIP-seq
MIRT1040740	hsa-miR-544b	CLIP-seq
MIRT1040741	hsa-miR-548k	CLIP-seq
MIRT1040742	hsa-miR-603	CLIP-seq
MIRT1040743	hsa-miR-767-5p	CLIP-seq
MIRT1040724	hsa-miR-29a	CLIP-seq
MIRT1040725	hsa-miR-29b	CLIP-seq
MIRT1040726	hsa-miR-29c	CLIP-seq
MIRT1040734	hsa-miR-3973	CLIP-seq
MIRT1040738	hsa-miR-4729	CLIP-seq
MIRT1040739	hsa-miR-4749-3p	CLIP-seq
MIRT1040741	hsa-miR-548k	CLIP-seq
MIRT1040743	hsa-miR-767-5p	CLIP-seq
MIRT2544476	hsa-miR-4261	CLIP-seq
MIRT2544477	hsa-miR-4768-3p	CLIP-seq
MIRT1040723	hsa-miR-296-5p	CLIP-seq
MIRT1040728	hsa-miR-3616-3p	CLIP-seq
MIRT1040729	hsa-miR-3622a-3p	CLIP-seq
MIRT1040730	hsa-miR-3622b-3p	CLIP-seq
MIRT2544476	hsa-miR-4261	CLIP-seq
MIRT1040735	hsa-miR-4286	CLIP-seq
MIRT1040737	hsa-miR-4721	CLIP-seq
MIRT1040739	hsa-miR-4749-3p	CLIP-seq
MIRT2544477	hsa-miR-4768-3p	CLIP-seq
MIRT1040740	hsa-miR-544b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0045202	Component	Synapse	IBA
GO:0072534	Component	Perineuronal net	IBA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q96S86

Protein name

Hyaluronan and proteoglycan link protein 3

Protein function

May function in hyaluronic acid binding.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	52 → 163	Immunoglobulin V-set domain	Domain
PF00193	Xlink	166 → 260	Extracellular link domain	Domain
PF00193	Xlink	267 → 357	Extracellular link domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in spleen and placenta. {ECO:0000269|PubMed:12663660}.

Sequence

MGLLLLVPLLLLPGSYGLPFYNGFYYSNSANDQNLGNGHGKDLLNGVKLVVETPEETLFT
YQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVH
LRQDKEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNGRYQFN
FHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAP
GVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIAKVGQLF
AAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPDPQSRLYGVYCYRQH

Sequence length

360

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Colorectal Cancer	Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Renal Cell	Associate	36374334, 39871215
Diabetes Gestational	Associate	25676578
Lung Diseases Interstitial	Associate	23897225
Melanoma	Associate	33753855
Neoplasms	Associate	36374334
Prostatic Neoplasms	Associate	28084441, 29465788, 32486483
Triple Negative Breast Neoplasms	Associate	28474731

HAPLN3 (hyaluronan and proteoglycan link protein 3)