Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	145282
Gene name	Mirror-image polydactyly 1
Gene symbol	MIPOL1
Synonyms (NCBI Gene)	CCDC193
Chromosome	14
Chromosome location	14q13.3-q21.1
Summary	This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also know

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Show/Hide all (212)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024688	hsa-miR-215-5p	Microarray	19074876
MIRT026684	hsa-miR-192-5p	Microarray	19074876
MIRT039001	hsa-let-7a-3p	CLASH	23622248
MIRT723433	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT723432	hsa-miR-593-5p	HITS-CLIP	19536157
MIRT723431	hsa-miR-183-5p	HITS-CLIP	19536157
MIRT723430	hsa-miR-1271-5p	HITS-CLIP	19536157
MIRT723429	hsa-miR-96-5p	HITS-CLIP	19536157
MIRT504457	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT522482	hsa-miR-4495	HITS-CLIP	21572407
MIRT522481	hsa-miR-379-3p	HITS-CLIP	21572407
MIRT522480	hsa-miR-411-3p	HITS-CLIP	21572407
MIRT522479	hsa-miR-380-3p	HITS-CLIP	21572407
MIRT522478	hsa-miR-3650	HITS-CLIP	21572407
MIRT522477	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT504456	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504455	hsa-miR-4666b	HITS-CLIP	21572407
MIRT504454	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT679285	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679284	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT679283	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT679282	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT679281	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT679280	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT679279	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679278	hsa-miR-1976	HITS-CLIP	23824327
MIRT679277	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679276	hsa-miR-4297	HITS-CLIP	23824327
MIRT679275	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT679274	hsa-miR-4497	HITS-CLIP	23824327
MIRT679273	hsa-miR-4279	HITS-CLIP	23824327
MIRT679272	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT522483	hsa-miR-4517	PAR-CLIP	21572407
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT522482	hsa-miR-4495	PAR-CLIP	21572407
MIRT522481	hsa-miR-379-3p	PAR-CLIP	21572407
MIRT522480	hsa-miR-411-3p	PAR-CLIP	21572407
MIRT522479	hsa-miR-380-3p	PAR-CLIP	21572407
MIRT522478	hsa-miR-3650	PAR-CLIP	21572407
MIRT522477	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504455	hsa-miR-4666b	PAR-CLIP	21572407
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504455	hsa-miR-4666b	PAR-CLIP	21572407
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT522483	hsa-miR-4517	PAR-CLIP	22012620
MIRT522482	hsa-miR-4495	PAR-CLIP	22012620
MIRT522481	hsa-miR-379-3p	PAR-CLIP	22012620
MIRT522480	hsa-miR-411-3p	PAR-CLIP	22012620
MIRT522479	hsa-miR-380-3p	PAR-CLIP	22012620
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT522483	hsa-miR-4517	PAR-CLIP	23446348
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522482	hsa-miR-4495	PAR-CLIP	23446348
MIRT522481	hsa-miR-379-3p	PAR-CLIP	23446348
MIRT522480	hsa-miR-411-3p	PAR-CLIP	23446348
MIRT522479	hsa-miR-380-3p	PAR-CLIP	23446348
MIRT522478	hsa-miR-3650	PAR-CLIP	23446348
MIRT522477	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504455	hsa-miR-4666b	PAR-CLIP	23446348
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504455	hsa-miR-4666b	PAR-CLIP	23446348
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT723433	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT723432	hsa-miR-593-5p	HITS-CLIP	19536157
MIRT723431	hsa-miR-183-5p	HITS-CLIP	19536157
MIRT723430	hsa-miR-1271-5p	HITS-CLIP	19536157
MIRT723429	hsa-miR-96-5p	HITS-CLIP	19536157
MIRT504457	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT522482	hsa-miR-4495	HITS-CLIP	21572407
MIRT522481	hsa-miR-379-3p	HITS-CLIP	21572407
MIRT522480	hsa-miR-411-3p	HITS-CLIP	21572407
MIRT522479	hsa-miR-380-3p	HITS-CLIP	21572407
MIRT522478	hsa-miR-3650	HITS-CLIP	21572407
MIRT522477	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT504456	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504455	hsa-miR-4666b	HITS-CLIP	21572407
MIRT504454	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT679285	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679284	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT679283	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT679282	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT679281	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT679280	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT679279	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679278	hsa-miR-1976	HITS-CLIP	23824327
MIRT679277	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679276	hsa-miR-4297	HITS-CLIP	23824327
MIRT679275	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT679274	hsa-miR-4497	HITS-CLIP	23824327
MIRT679273	hsa-miR-4279	HITS-CLIP	23824327
MIRT679272	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT522483	hsa-miR-4517	PAR-CLIP	21572407
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT522482	hsa-miR-4495	PAR-CLIP	21572407
MIRT522481	hsa-miR-379-3p	PAR-CLIP	21572407
MIRT522480	hsa-miR-411-3p	PAR-CLIP	21572407
MIRT522479	hsa-miR-380-3p	PAR-CLIP	21572407
MIRT522478	hsa-miR-3650	PAR-CLIP	21572407
MIRT522477	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504455	hsa-miR-4666b	PAR-CLIP	21572407
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504455	hsa-miR-4666b	PAR-CLIP	21572407
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT522483	hsa-miR-4517	PAR-CLIP	22012620
MIRT522482	hsa-miR-4495	PAR-CLIP	22012620
MIRT522481	hsa-miR-379-3p	PAR-CLIP	22012620
MIRT522480	hsa-miR-411-3p	PAR-CLIP	22012620
MIRT522479	hsa-miR-380-3p	PAR-CLIP	22012620
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT522483	hsa-miR-4517	PAR-CLIP	23446348
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522482	hsa-miR-4495	PAR-CLIP	23446348
MIRT522481	hsa-miR-379-3p	PAR-CLIP	23446348
MIRT522480	hsa-miR-411-3p	PAR-CLIP	23446348
MIRT522479	hsa-miR-380-3p	PAR-CLIP	23446348
MIRT522478	hsa-miR-3650	PAR-CLIP	23446348
MIRT522477	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504455	hsa-miR-4666b	PAR-CLIP	23446348
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504457	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504456	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504455	hsa-miR-4666b	PAR-CLIP	23446348
MIRT504454	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1149396	hsa-miR-23a	CLIP-seq
MIRT1149397	hsa-miR-23b	CLIP-seq
MIRT1149398	hsa-miR-23c	CLIP-seq
MIRT1149399	hsa-miR-4643	CLIP-seq
MIRT1149400	hsa-miR-1323	CLIP-seq
MIRT1149401	hsa-miR-203	CLIP-seq
MIRT1149402	hsa-miR-2053	CLIP-seq
MIRT1149403	hsa-miR-2113	CLIP-seq
MIRT1149404	hsa-miR-302f	CLIP-seq
MIRT1149405	hsa-miR-3144-3p	CLIP-seq
MIRT1149406	hsa-miR-3163	CLIP-seq
MIRT1149407	hsa-miR-340	CLIP-seq
MIRT1149408	hsa-miR-4282	CLIP-seq
MIRT1149409	hsa-miR-4464	CLIP-seq
MIRT1149410	hsa-miR-4668-3p	CLIP-seq
MIRT1149411	hsa-miR-4748	CLIP-seq
MIRT1149412	hsa-miR-4753-3p	CLIP-seq
MIRT1149413	hsa-miR-4797-5p	CLIP-seq
MIRT1149414	hsa-miR-4799-5p	CLIP-seq
MIRT1149415	hsa-miR-548o	CLIP-seq
MIRT1149416	hsa-miR-569	CLIP-seq
MIRT1149417	hsa-miR-590-3p	CLIP-seq
MIRT1149418	hsa-miR-600	CLIP-seq
MIRT1149419	hsa-miR-633	CLIP-seq
MIRT1149420	hsa-miR-875-5p	CLIP-seq
MIRT2042502	hsa-miR-338-5p	CLIP-seq
MIRT2042503	hsa-miR-3611	CLIP-seq
MIRT2042504	hsa-miR-141	CLIP-seq
MIRT2042505	hsa-miR-200a	CLIP-seq
MIRT2272129	hsa-miR-140-5p	CLIP-seq
MIRT2272130	hsa-miR-15a	CLIP-seq
MIRT2272131	hsa-miR-15b	CLIP-seq
MIRT2272132	hsa-miR-16	CLIP-seq
MIRT2272133	hsa-miR-182	CLIP-seq
MIRT2272134	hsa-miR-1910	CLIP-seq
MIRT2272135	hsa-miR-195	CLIP-seq
MIRT2272136	hsa-miR-214	CLIP-seq
MIRT2272137	hsa-miR-3189-3p	CLIP-seq
MIRT2272138	hsa-miR-323b-3p	CLIP-seq
MIRT2272139	hsa-miR-3619-5p	CLIP-seq
MIRT2272140	hsa-miR-3658	CLIP-seq
MIRT2272141	hsa-miR-374a	CLIP-seq
MIRT2272142	hsa-miR-374b	CLIP-seq
MIRT2272143	hsa-miR-3940-5p	CLIP-seq
MIRT2272144	hsa-miR-424	CLIP-seq
MIRT1149408	hsa-miR-4282	CLIP-seq
MIRT2272145	hsa-miR-4291	CLIP-seq
MIRT2272146	hsa-miR-4470	CLIP-seq
MIRT2272147	hsa-miR-4507	CLIP-seq
MIRT2272148	hsa-miR-4796-3p	CLIP-seq
MIRT1149414	hsa-miR-4799-5p	CLIP-seq
MIRT2272149	hsa-miR-497	CLIP-seq
MIRT2272150	hsa-miR-517b	CLIP-seq
MIRT2272151	hsa-miR-520g	CLIP-seq
MIRT2272152	hsa-miR-520h	CLIP-seq
MIRT2272153	hsa-miR-545	CLIP-seq
MIRT2272154	hsa-miR-761	CLIP-seq
MIRT2272155	hsa-miR-922	CLIP-seq
MIRT2272156	hsa-miR-944	CLIP-seq
MIRT2042504	hsa-miR-141	CLIP-seq
MIRT2042505	hsa-miR-200a	CLIP-seq
MIRT2454144	hsa-miR-1185	CLIP-seq
MIRT2454145	hsa-miR-3679-5p	CLIP-seq
MIRT2454146	hsa-miR-4712-3p	CLIP-seq
MIRT2454147	hsa-miR-601	CLIP-seq
MIRT2454148	hsa-miR-616	CLIP-seq
MIRT2571158	hsa-miR-128	CLIP-seq
MIRT2571159	hsa-miR-320a	CLIP-seq
MIRT2571160	hsa-miR-320b	CLIP-seq
MIRT2571161	hsa-miR-320c	CLIP-seq
MIRT2571162	hsa-miR-320d	CLIP-seq
MIRT2042502	hsa-miR-338-5p	CLIP-seq
MIRT2571163	hsa-miR-3681	CLIP-seq
MIRT2571164	hsa-miR-4429	CLIP-seq
MIRT2571165	hsa-miR-4691-5p	CLIP-seq
MIRT2571166	hsa-miR-4699-3p	CLIP-seq
MIRT2571167	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 26871637, 29892012, 31515488, 32296183
GO:0005634	Component	Nucleus	IDA	19667180
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183

MIM	HGNC	e!Ensembl
606850	21460	ENSG00000151338

Q8TD10

Protein name

Mirror-image polydactyly gene 1 protein

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed very weakly in heart, liver, skeletal muscle, kidney, pancreas and fetal kidney. Not detected in brain, placenta and lung. {ECO:0000269|PubMed:11954550}.

Sequence

MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQR
STNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKEL
DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEA
VMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN
GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH
LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN
YTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ
KLERLVDVLRKKVGTGTMRTVI

Sequence length

442

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIPOL1-related disorder	Uncertain significance; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYDACTYLY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYDACTYLY, POSTAXIAL	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	32321829	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	21148747	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly	Associate	28488682	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous Cell Carcinoma of Head and Neck	Associate	35922788	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	33191407	★★★★★ ★☆☆☆☆ Found in Text Mining only

MIPOL1 (mirror-image polydactyly 1)