Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
144455
Gene name Gene Name - the full gene name approved by the HGNC.
E2F transcription factor 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
E2F7
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007177 hsa-miR-26a-5p ChIP-seq, Immunoblot, Immunofluorescence, 23096114
MIRT007177 hsa-miR-26a-5p ChIP-seq, Immunoblot, Immunofluorescence, 23096114
MIRT007177 hsa-miR-26a-5p ChIP-seq, Immunoblot, Immunofluorescence, 23096114
MIRT007177 hsa-miR-26a-5p ChIP-seq, Immunoblot, Immunofluorescence, 23096114
MIRT021284 hsa-miR-125a-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
TP53 Activation 22802528
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 22802528
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612046 23820 ENSG00000165891
Protein
UniProt ID Q96AV8
Protein name Transcription factor E2F7 (E2F-7)
Protein function Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins an
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02319 E2F_TDP 143 211 E2F/DP family winged-helix DNA-binding domain Domain
PF02319 E2F_TDP 283 367 E2F/DP family winged-helix DNA-binding domain Domain
Sequence
MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVDRSRMAPKTPIKNEPIDLSKQKKF
TPERNPITPVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAFTD
SLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLG
VERRRIYDIVNVLESLHLVSRVAKNQYGWHG
RHSLPKTLRNLQRLGEEQKYEEQMAYLQQ
KELDLIDYKFGERKKDGDPDSQEQQLLDFSEPDCPSSSANSRKDKSLRIMSQKFVMLFLV
SKTKIVTLDVAAKILIEESQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRK
PAFKWIG
PVDFSSSDEELVDVSASVLPELKRETYGQIQVCAKQKLARHGSFNTVQASERI
QRKVNSEPSSPYREEQGSGGYSLEIGSLAAVYRQKIEDNSQGKAFASKRVVPPSSSLDPV
APFPVLSVDPEYCVNPLAHPVFSVAQTDLQAFSMQNGLNGQVDVSLASAASAVESLKPAL
LAGQPLVYVPSASLFMLYGSLQEGPASGSGSERDDRSSEAPATVELSSAPSAQKRLCEER
KPQEEDEPATKRQSREYEDGPLSLVMPKKPSDSTDLASPKTMGNRASIPLKDIHVNGQLP
AAEEISGKATANSLVSSEWGNPSRNTDVEKPSKENESTKEPSLLQYLCVQSPAGLNGFNV
LLSGSQTPPTVGPSSGQLPSFSVPCMVLPSPPLGPFPVLYSPAMPGPVSSTLGALPNTGP
VNFSLPGLGSIAQLLVGPTAVVNPKSSTLPSADPQLQSQPSLNLSPVMSRSHSVVQQPES
PVYVGHPVSVVKLHQSPVPVTPKSIQRTHRETFFKTPGSLGDPVLKRRERNQSRNTSSAQ
RRLEIPSGGAD
Sequence length 911
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
29754146
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 34902990, 38241554
Adenocarcinoma of Lung Stimulate 35984189
Brain Neoplasms Stimulate 33381564
Breast Neoplasms Associate 26397135
Carcinogenesis Inhibit 29363506
Carcinogenesis Associate 37028765, 38241554
Carcinoma Hepatocellular Associate 24574752, 31086464, 32104698, 33201900, 35729702
Carcinoma Hepatocellular Stimulate 35924788
Carcinoma Non Small Cell Lung Associate 32508344
Carcinoma Pancreatic Ductal Associate 32592206