CRY2 (cryptochrome circadian regulator 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1408
Gene name Gene Name - the full gene name approved by the HGNC.
Cryptochrome circadian regulator 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CRY2
Synonyms (NCBI Gene) Gene synonyms aliases
HCRY2, PHLL2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulatio
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1223)
miRTarBase ID miRNA Experiments Reference
MIRT019611 hsa-miR-340-5p Sequencing 20371350
MIRT020147 hsa-miR-130b-3p Sequencing 20371350
MIRT028006 hsa-miR-93-5p Sequencing 20371350
MIRT028213 hsa-miR-33a-5p Sequencing 20371350
MIRT037929 hsa-miR-532-3p CLASH 23622248
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
Transcription factor Regulation Reference
ARNTL Activation 22750052
ARNTL Unknown 17660446
CLOCK Activation 22750052
CLOCK Unknown 17660446
NPAS2 Unknown 17660446
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(69)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 12397359, 14672706, 15147242
GO:0000166 Function Nucleotide binding IEA
GO:0000719 Process Photoreactive repair IDA 12627958
GO:0000976 Function Transcription cis-regulatory region binding IEA
GO:0000976 Function Transcription cis-regulatory region binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603732 2385 ENSG00000121671
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q49AN0
Protein name Cryptochrome-2
Protein function Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in g
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00875 DNA_photolyase 24 → 187 DNA photolyase Domain
PF03441 FAD_binding_7 305 → 505 FAD binding domain of DNA photolyase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest level
Sequence
Sequence length 593
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Circadian rhythm  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Show/Hide Text Mining Associations (62)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 36385012
Amyotrophic Lateral Sclerosis Associate 34142702
Anxiety Associate 38102312
Attention Deficit and Disruptive Behavior Disorders Inhibit 31708917
Bipolar Disorder Associate 20195522, 20856823, 23951166, 25989161
Breast Neoplasms Associate 20233903, 25485508, 25740058, 29958276, 31358835, 31739444, 39193850
Breast Neoplasms Stimulate 31358835
Breast Neoplasms Inhibit 37024472
Carcinoma Hepatocellular Associate 34745328
Carcinoma Non Small Cell Lung Associate 32246902, 35575281