Gene Gene information from NCBI Gene database.
Entrez ID 140609
Gene name NIMA related kinase 7
Gene symbol NEK7
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1q31.3
Summary NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans `never in mitosis A` gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
miRNA miRNA information provided by mirtarbase database.
802
miRTarBase ID miRNA Experiments Reference
MIRT019647 hsa-miR-340-5p Sequencing 20371350
MIRT027390 hsa-miR-101-3p Sequencing 20371350
MIRT047638 hsa-miR-10a-5p CLASH 23622248
MIRT047478 hsa-miR-10b-5p CLASH 23622248
MIRT472386 hsa-miR-548ac PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000922 Component Spindle pole IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 19941817, 26522158
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606848 13386 ENSG00000151414
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TDX7
Protein name Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
Protein function Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis
PDB 2WQM , 2WQN , 5DE2 , 6NPY , 6S73 , 6S75 , 6S76 , 8EJ4 , 8SXN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 34 292 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. {ECO:0000269|PubMed:11701951}.
Sequence
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  NOD-like receptor signaling pathway   Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
EML4 and NUDC in mitotic spindle formation