Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
140609
Gene name Gene Name - the full gene name approved by the HGNC.
NIMA related kinase 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NEK7
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q31.3
Summary Summary of gene provided in NCBI Entrez Gene.
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans `never in mitosis A` gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019647 hsa-miR-340-5p Sequencing 20371350
MIRT027390 hsa-miR-101-3p Sequencing 20371350
MIRT047638 hsa-miR-10a-5p CLASH 23622248
MIRT047478 hsa-miR-10b-5p CLASH 23622248
MIRT472386 hsa-miR-548ac PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000922 Component Spindle pole IEA
GO:0004674 Function Protein serine/threonine kinase activity ISS
GO:0005515 Function Protein binding IPI 26188091, 26814970, 32296183, 32814053
GO:0005524 Function ATP binding IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606848 13386 ENSG00000151414
Protein
UniProt ID Q8TDX7
Protein name Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
Protein function Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis
PDB 2WQM , 2WQN , 5DE2 , 6NPY , 6S73 , 6S75 , 6S76 , 8EJ4 , 8SXN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 34 292 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. {ECO:0000269|PubMed:11701951}.
Sequence
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  NOD-like receptor signaling pathway   Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
EML4 and NUDC in mitotic spindle formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Insomnia Insomnia GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 40307363
Arthritis Rheumatoid Associate 35807344
Breast Neoplasms Associate 35807344
Calcinosis Cutis Associate 32184261
Carcinoma Non Small Cell Lung Associate 35807344
Diabetic Angiopathies Associate 33323459
Diabetic Foot Associate 33323459
Gout Associate 35807344
Inflammation Associate 35807344
Liver Cirrhosis Associate 35807344