NEK7 (NIMA related kinase 7)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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140609 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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NIMA related kinase 7 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NEK7 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q31.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans `never in mitosis A` gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002] |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q8TDX7 | ||||||||||
Protein name | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | ||||||||||
Protein function | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis | ||||||||||
PDB | 2WQM , 2WQN , 5DE2 , 6NPY , 6S73 , 6S75 , 6S76 , 8EJ4 , 8SXN | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. {ECO:0000269|PubMed:11701951}. | ||||||||||
Sequence | |||||||||||
Sequence length | 302 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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