Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1404
Gene name	Hyaluronan and proteoglycan link protein 1
Gene symbol	HAPLN1
Synonyms (NCBI Gene)	CRT1CRTL1
Chromosome	5
Chromosome location	5q14.3

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017946	hsa-miR-335-5p	Microarray	18185580
MIRT030924	hsa-miR-21-5p	Microarray	18591254
MIRT623717	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT623716	hsa-miR-23c	HITS-CLIP	23824327
MIRT623715	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT623714	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT623713	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT623712	hsa-miR-3148	HITS-CLIP	23824327
MIRT623711	hsa-miR-6124	HITS-CLIP	23824327
MIRT623710	hsa-miR-3978	HITS-CLIP	23824327
MIRT623709	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT623717	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT623716	hsa-miR-23c	HITS-CLIP	23824327
MIRT623715	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT623714	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT623713	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT623712	hsa-miR-3148	HITS-CLIP	23824327
MIRT623711	hsa-miR-6124	HITS-CLIP	23824327
MIRT623710	hsa-miR-3978	HITS-CLIP	23824327
MIRT623709	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1040660	hsa-miR-125a-5p	CLIP-seq
MIRT1040661	hsa-miR-125b	CLIP-seq
MIRT1040662	hsa-miR-1284	CLIP-seq
MIRT1040663	hsa-miR-1303	CLIP-seq
MIRT1040664	hsa-miR-133a	CLIP-seq
MIRT1040665	hsa-miR-146b-3p	CLIP-seq
MIRT1040666	hsa-miR-153	CLIP-seq
MIRT1040667	hsa-miR-203	CLIP-seq
MIRT1040668	hsa-miR-29a	CLIP-seq
MIRT1040669	hsa-miR-29b	CLIP-seq
MIRT1040670	hsa-miR-29c	CLIP-seq
MIRT1040671	hsa-miR-3065-3p	CLIP-seq
MIRT1040672	hsa-miR-3162-5p	CLIP-seq
MIRT1040673	hsa-miR-3163	CLIP-seq
MIRT1040674	hsa-miR-3173-5p	CLIP-seq
MIRT1040675	hsa-miR-331-5p	CLIP-seq
MIRT1040676	hsa-miR-337-3p	CLIP-seq
MIRT1040677	hsa-miR-3609	CLIP-seq
MIRT1040678	hsa-miR-369-3p	CLIP-seq
MIRT1040679	hsa-miR-374a	CLIP-seq
MIRT1040680	hsa-miR-374b	CLIP-seq
MIRT1040681	hsa-miR-380	CLIP-seq
MIRT1040682	hsa-miR-383	CLIP-seq
MIRT1040683	hsa-miR-410	CLIP-seq
MIRT1040684	hsa-miR-4273	CLIP-seq
MIRT1040685	hsa-miR-4319	CLIP-seq
MIRT1040686	hsa-miR-448	CLIP-seq
MIRT1040687	hsa-miR-4677-5p	CLIP-seq
MIRT1040688	hsa-miR-4678	CLIP-seq
MIRT1040689	hsa-miR-4684-3p	CLIP-seq
MIRT1040690	hsa-miR-4714-3p	CLIP-seq
MIRT1040691	hsa-miR-4729	CLIP-seq
MIRT1040692	hsa-miR-4772-5p	CLIP-seq
MIRT1040693	hsa-miR-4775	CLIP-seq
MIRT1040694	hsa-miR-490-5p	CLIP-seq
MIRT1040695	hsa-miR-544	CLIP-seq
MIRT1040696	hsa-miR-548ah	CLIP-seq
MIRT1040697	hsa-miR-548t	CLIP-seq
MIRT1040698	hsa-miR-582-5p	CLIP-seq
MIRT1040699	hsa-miR-605	CLIP-seq
MIRT1040700	hsa-miR-617	CLIP-seq
MIRT1040701	hsa-miR-874	CLIP-seq
MIRT1040702	hsa-miR-940	CLIP-seq
MIRT1549444	hsa-miR-1197	CLIP-seq
MIRT1549445	hsa-miR-548p	CLIP-seq
MIRT1040666	hsa-miR-153	CLIP-seq
MIRT1040686	hsa-miR-448	CLIP-seq
MIRT1040698	hsa-miR-582-5p	CLIP-seq
MIRT1040664	hsa-miR-133a	CLIP-seq
MIRT2240960	hsa-miR-2116	CLIP-seq
MIRT2240961	hsa-miR-23a	CLIP-seq
MIRT2240962	hsa-miR-23b	CLIP-seq
MIRT2240963	hsa-miR-3149	CLIP-seq
MIRT2240964	hsa-miR-4328	CLIP-seq
MIRT2240965	hsa-miR-4496	CLIP-seq
MIRT2240966	hsa-miR-4652-3p	CLIP-seq
MIRT1040687	hsa-miR-4677-5p	CLIP-seq
MIRT2450951	hsa-miR-3147	CLIP-seq
MIRT2450952	hsa-miR-3682-3p	CLIP-seq
MIRT2450953	hsa-miR-4425	CLIP-seq
MIRT2450954	hsa-miR-450b-3p	CLIP-seq
MIRT2450955	hsa-miR-769-3p	CLIP-seq
MIRT2450951	hsa-miR-3147	CLIP-seq
MIRT2450952	hsa-miR-3682-3p	CLIP-seq
MIRT2450953	hsa-miR-4425	CLIP-seq
MIRT2450954	hsa-miR-450b-3p	CLIP-seq
MIRT2450955	hsa-miR-769-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0030021	Function	Extracellular matrix structural constituent conferring compression resistance	RCA	20551380, 23979707, 27068509, 28327460
GO:0031012	Component	Extracellular matrix	HDA	20551380
GO:0031012	Component	Extracellular matrix	HDA	23979707, 27068509, 28327460
GO:0031012	Component	Extracellular matrix	IEA
GO:0031012	Component	Extracellular matrix	TAS	2286376
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0072534	Component	Perineuronal net	IBA

MIM	HGNC	e!Ensembl
115435	2380	ENSG00000145681

P10915

Protein name

Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein)

Protein function

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	44 → 152	Immunoglobulin V-set domain	Domain
PF00193	Xlink	159 → 253	Extracellular link domain	Domain
PF00193	Xlink	260 → 350	Extracellular link domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Weakly expressed in the brain. {ECO:0000269|PubMed:11027579, ECO:0000269|PubMed:12663660}.

Sequence

MKSLLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLP
CKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDS
DASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQA
CLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGF
WDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILG
YDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN

Sequence length

354

Interactions

View interactions

	Reactome
			ECM proteoglycans

HAPLN1 (hyaluronan and proteoglycan link protein 1)