Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	140
Gene name Gene Name - the full gene name approved by the HGNC.	Adenosine A3 receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ADORA3
Synonyms (NCBI Gene) Gene synonyms aliases	A3AR
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates

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miRTarBase ID	miRNA	Experiments	Reference
MIRT717466	hsa-miR-548e-5p	HITS-CLIP	19536157
MIRT717465	hsa-miR-15a-5p	HITS-CLIP	19536157
MIRT717464	hsa-miR-15b-5p	HITS-CLIP	19536157
MIRT717463	hsa-miR-16-5p	HITS-CLIP	19536157
MIRT717462	hsa-miR-195-5p	HITS-CLIP	19536157
MIRT717461	hsa-miR-424-5p	HITS-CLIP	19536157
MIRT717460	hsa-miR-497-5p	HITS-CLIP	19536157
MIRT717459	hsa-miR-6838-5p	HITS-CLIP	19536157
MIRT717458	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT717457	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT717456	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT717455	hsa-miR-103a-3p	HITS-CLIP	19536157
MIRT717454	hsa-miR-107	HITS-CLIP	19536157
MIRT717453	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT717452	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT717451	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT717466	hsa-miR-548e-5p	HITS-CLIP	19536157
MIRT717465	hsa-miR-15a-5p	HITS-CLIP	19536157
MIRT717464	hsa-miR-15b-5p	HITS-CLIP	19536157
MIRT717463	hsa-miR-16-5p	HITS-CLIP	19536157
MIRT717462	hsa-miR-195-5p	HITS-CLIP	19536157
MIRT717461	hsa-miR-424-5p	HITS-CLIP	19536157
MIRT717460	hsa-miR-497-5p	HITS-CLIP	19536157
MIRT717459	hsa-miR-6838-5p	HITS-CLIP	19536157
MIRT717458	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT717457	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT717456	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT717455	hsa-miR-103a-3p	HITS-CLIP	19536157
MIRT717454	hsa-miR-107	HITS-CLIP	19536157
MIRT717453	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT717452	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT717451	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT769626	hsa-miR-219-5p	CLIP-seq
MIRT769627	hsa-miR-3064-5p	CLIP-seq
MIRT769628	hsa-miR-3921	CLIP-seq
MIRT769629	hsa-miR-4265	CLIP-seq
MIRT769630	hsa-miR-4296	CLIP-seq
MIRT769631	hsa-miR-4322	CLIP-seq
MIRT769632	hsa-miR-4417	CLIP-seq
MIRT769633	hsa-miR-4445	CLIP-seq
MIRT769634	hsa-miR-4640-5p	CLIP-seq
MIRT769635	hsa-miR-4649-3p	CLIP-seq
MIRT769636	hsa-miR-4653-5p	CLIP-seq
MIRT769637	hsa-miR-4726-5p	CLIP-seq
MIRT769638	hsa-miR-4782-3p	CLIP-seq
MIRT769639	hsa-miR-508-3p	CLIP-seq
MIRT769640	hsa-miR-548c-3p	CLIP-seq
MIRT769641	hsa-miR-604	CLIP-seq
MIRT769642	hsa-miR-647	CLIP-seq
MIRT2167943	hsa-miR-2110	CLIP-seq
MIRT2167944	hsa-miR-3974	CLIP-seq
MIRT2167945	hsa-miR-4271	CLIP-seq
MIRT2167946	hsa-miR-4725-3p	CLIP-seq
MIRT2167947	hsa-miR-493	CLIP-seq
MIRT2167948	hsa-miR-653	CLIP-seq
MIRT2383962	hsa-miR-1224-3p	CLIP-seq
MIRT2383963	hsa-miR-1260	CLIP-seq
MIRT2383964	hsa-miR-1260b	CLIP-seq
MIRT2383965	hsa-miR-1270	CLIP-seq
MIRT2383966	hsa-miR-1280	CLIP-seq
MIRT2383967	hsa-miR-4683	CLIP-seq
MIRT2383968	hsa-miR-4708-5p	CLIP-seq
MIRT2383969	hsa-miR-532-3p	CLIP-seq
MIRT2383970	hsa-miR-620	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
NFKB1	Unknown	17216675
RELA	Unknown	17216675

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001609	Function	G protein-coupled adenosine receptor activity	IBA
GO:0001609	Function	G protein-coupled adenosine receptor activity	IEA
GO:0001973	Process	G protein-coupled adenosine receptor signaling pathway	IBA
GO:0001973	Process	G protein-coupled adenosine receptor signaling pathway	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8399349
GO:0006954	Process	Inflammatory response	TAS	9164961
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	8399349, 9380026
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	9380026
GO:0008016	Process	Regulation of heart contraction	TAS	9837869
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	27886186
GO:0009611	Process	Response to wounding	TAS	9837869
GO:0014061	Process	Regulation of norepinephrine secretion	IEA
GO:0016020	Component	Membrane	IEA
GO:0030336	Process	Negative regulation of cell migration	IMP	27886186
GO:0030425	Component	Dendrite	IBA
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IMP	27886186
GO:0042734	Component	Presynaptic membrane	IEA
GO:0045202	Component	Synapse	IBA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA

MIM	HGNC	e!Ensembl
600445	268	ENSG00000282608

Protein

UniProt ID

P0DMS8

Protein name

Adenosine receptor A3

Protein function

[Isoform 2]: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299).

PDB

8X16 , 8X17

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	29 → 282	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level). {ECO:0000269|PubMed:27886186}.

Sequence

MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

Sequence length

318

Interactions

View interactions

	KEGG		Reactome
	cGMP-PKG signaling pathway Sphingolipid signaling pathway Neuroactive ligand-receptor interaction		Adenosine P1 receptors G alpha (i) signalling events

ADORA3 (adenosine A3 receptor)