CRHR2 (corticotropin releasing hormone receptor 2)

Gene

• Entrez ID: 1395
• Gene name: Corticotropin releasing hormone receptor 2
• Gene symbol: CRHR2
• Synonyms (NCBI Gene): CRF-RB, CRF2, CRFR2, HM-CRF
• Chromosome: 7
• Chromosome location: 7p14.3
• Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related pep

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs7793837	A>C,T	Drug-response	Genic upstream transcript variant, intron variant, 5 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017454	hsa-miR-335-5p	Microarray	18185580
MIRT909564	hsa-miR-1237	CLIP-seq
MIRT909565	hsa-miR-1248	CLIP-seq
MIRT909566	hsa-miR-1285	CLIP-seq
MIRT909567	hsa-miR-19a	CLIP-seq
MIRT909568	hsa-miR-19b	CLIP-seq
MIRT909569	hsa-miR-296-5p	CLIP-seq
MIRT909570	hsa-miR-3134	CLIP-seq
MIRT909571	hsa-miR-3187-5p	CLIP-seq
MIRT909572	hsa-miR-3194-3p	CLIP-seq
MIRT909573	hsa-miR-326	CLIP-seq
MIRT909574	hsa-miR-330-5p	CLIP-seq
MIRT909575	hsa-miR-378g	CLIP-seq
MIRT909576	hsa-miR-4301	CLIP-seq
MIRT909577	hsa-miR-4426	CLIP-seq
MIRT909578	hsa-miR-4486	CLIP-seq
MIRT909579	hsa-miR-4521	CLIP-seq
MIRT909580	hsa-miR-4647	CLIP-seq
MIRT909581	hsa-miR-4662b	CLIP-seq
MIRT909582	hsa-miR-4696	CLIP-seq
MIRT909583	hsa-miR-4764-5p	CLIP-seq
MIRT909584	hsa-miR-483-5p	CLIP-seq
MIRT909585	hsa-miR-612	CLIP-seq
MIRT909586	hsa-miR-767-3p	CLIP-seq
MIRT909587	hsa-miR-942	CLIP-seq
MIRT1969604	hsa-miR-103a	CLIP-seq
MIRT1969605	hsa-miR-107	CLIP-seq
MIRT1969606	hsa-miR-1301	CLIP-seq
MIRT1969607	hsa-miR-4328	CLIP-seq
MIRT1969608	hsa-miR-4684-3p	CLIP-seq
MIRT1969609	hsa-miR-5047	CLIP-seq
MIRT1969610	hsa-miR-548c-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	11329063, 20966082, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8536644
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	8536644
GO:0008528	Function	G protein-coupled peptide receptor activity	IBA
GO:0009755	Process	Hormone-mediated signaling pathway	IEA
GO:0015056	Function	Corticotrophin-releasing factor receptor activity	IBA
GO:0015056	Function	Corticotrophin-releasing factor receptor activity	TAS	9717834
GO:0016020	Component	Membrane	IEA
GO:0017046	Function	Peptide hormone binding	IBA
GO:0030425	Component	Dendrite	IBA
GO:0043404	Function	Corticotropin-releasing hormone receptor activity	IBA
GO:0043679	Component	Axon terminus	IBA
GO:0060291	Process	Long-term synaptic potentiation	IBA
GO:0071376	Process	Cellular response to corticotropin-releasing hormone stimulus	IEA

Other IDs

• MIM: 602034
• HGNC: 2358
• e!Ensembl: ENSG00000106113

Protein

• UniProt ID: Q13324
• Protein name: Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)
• Protein function: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protei
• PDB: 3N93, 3N95, 3N96, 6PB1, 7TRY, 7TS0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02793	HRM	37 → 101	Hormone receptor domain	Family
  PF00002	7tm_2	113 → 355	7 transmembrane receptor (Secretin family)	Family

• Sequence:

  MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALV
  ERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVN
  YLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESN
  EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIV
  AWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
  ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYC
  FFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV

• Sequence length: 411

Pathways

KEGG:

cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Cushing syndrome

Reactome:

Class B/2 (Secretin family receptors)
G alpha (s) signalling events
Synthesis, secretion, and deacylation of Ghrelin
ADORA2B mediated anti-inflammatory cytokines production