CPB2 (carboxypeptidase B2)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 1361
Gene name Carboxypeptidase B2
Gene symbol CPB2
Synonyms (NCBI Gene)
CPUPCPBTAFI
Chromosome 13
Chromosome location 13q14.13
Summary Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cl
miRNA miRNA information provided by mirtarbase database.
6
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (6)
miRTarBase ID miRNA Experiments Reference
MIRT029527 hsa-miR-26b-5p Microarray 19088304
MIRT905703 hsa-miR-3647-3p CLIP-seq
MIRT905704 hsa-miR-3682-5p CLIP-seq
MIRT905705 hsa-miR-4256 CLIP-seq
MIRT905706 hsa-miR-4282 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (21)
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity IEA
GO:0004181 Function Metallocarboxypeptidase activity IBA
GO:0004181 Function Metallocarboxypeptidase activity IEA
GO:0004181 Function Metallocarboxypeptidase activity TAS 1939207, 10651877
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603101 2300 ENSG00000080618
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96IY4
Protein name Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI)
Protein function Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fib
PDB 3D66 , 3D67 , 3D68 , 3LMS , 4P10 , 5HVF , 5HVG , 5HVH , 7NEE , 7NEU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02244 Propep_M14 30 → 105 Carboxypeptidase activation peptide Domain
PF00246 Peptidase_M14 129 → 411 Zinc carboxypeptidase Domain
Tissue specificity TISSUE SPECIFICITY: Plasma; synthesized in the liver.
Sequence
Sequence length 423
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Complement and coagulation cascades
Pancreatic secretion
Protein digestion and absorption 		  Metabolism of Angiotensinogen to Angiotensins
Regulation of Complement cascade
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AMENORRHEA — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CPB2-related disorder Benign; Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE, CHRONIC — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (66)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Androgen Insensitivity Syndrome Associate 31755939
★★★★★
★☆☆☆☆
Found in Text Mining only
Antithrombin III Deficiency Inhibit 37201530
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Associate 22163325
★★★★★
★☆☆☆☆
Found in Text Mining only
Behcet Syndrome Associate 18341631
★★★★★
★☆☆☆☆
Found in Text Mining only
Blood Coagulation Disorders Associate 21933309, 31140594
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Inhibit 27221823
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Small Cell Stimulate 15224354
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Associate 37442189
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Associate 18958767, 18974842, 19323787
★★★★★
★☆☆☆☆
Found in Text Mining only
Carotid Artery Thrombosis Associate 19323787, 19377074, 31781299
★★★★★
★☆☆☆☆
Found in Text Mining only