Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1361
Gene name Gene Name - the full gene name approved by the HGNC.	Carboxypeptidase B2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CPB2
Synonyms (NCBI Gene) Gene synonyms aliases	CPU, PCPB, TAFI
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q14.13
Summary Summary of gene provided in NCBI Entrez Gene.	Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029527	hsa-miR-26b-5p	Microarray	19088304
MIRT905703	hsa-miR-3647-3p	CLIP-seq
MIRT905704	hsa-miR-3682-5p	CLIP-seq
MIRT905705	hsa-miR-4256	CLIP-seq
MIRT905706	hsa-miR-4282	CLIP-seq
MIRT905707	hsa-miR-4468	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004180	Function	Carboxypeptidase activity	IEA
GO:0004181	Function	Metallocarboxypeptidase activity	IBA
GO:0004181	Function	Metallocarboxypeptidase activity	IEA
GO:0004181	Function	Metallocarboxypeptidase activity	TAS	1939207, 10651877
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	TAS	1939207, 10651877
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	1939207, 10651877
GO:0007596	Process	Blood coagulation	IEA
GO:0007599	Process	Hemostasis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042730	Process	Fibrinolysis	IBA
GO:0042730	Process	Fibrinolysis	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
603101	2300	ENSG00000080618

Protein

UniProt ID

Q96IY4

Protein name

Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI)

Protein function

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fib

PDB

3D66 , 3D67 , 3D68 , 3LMS , 4P10 , 5HVF , 5HVG , 5HVH , 7NEE , 7NEU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02244	Propep_M14	30 → 105	Carboxypeptidase activation peptide	Domain
PF00246	Peptidase_M14	129 → 411	Zinc carboxypeptidase	Domain

Tissue specificity

TISSUE SPECIFICITY: Plasma; synthesized in the liver.

Sequence

MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV

Sequence length

423

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades Pancreatic secretion Protein digestion and absorption		Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade

CPB2 (carboxypeptidase B2)