CPB2 (carboxypeptidase B2)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1361
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase B2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPB2
Synonyms (NCBI Gene) Gene synonyms aliases
CPU, PCPB, TAFI
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q14.13
Summary Summary of gene provided in NCBI Entrez Gene.
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cl
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT029527 hsa-miR-26b-5p Microarray 19088304
MIRT905703 hsa-miR-3647-3p CLIP-seq
MIRT905704 hsa-miR-3682-5p CLIP-seq
MIRT905705 hsa-miR-4256 CLIP-seq
MIRT905706 hsa-miR-4282 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0003331 Process Positive regulation of extracellular matrix constituent secretion IEA
GO:0004181 Function Metallocarboxypeptidase activity IBA 21873635
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0006508 Process Proteolysis IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603101 2300 ENSG00000080618
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96IY4
Protein name Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI)
Protein function Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fib
PDB 3D66 , 3D67 , 3D68 , 3LMS , 4P10 , 5HVF , 5HVG , 5HVH , 7NEE , 7NEU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02244 Propep_M14 30 → 105 Carboxypeptidase activation peptide Domain
PF00246 Peptidase_M14 129 → 411 Zinc carboxypeptidase Domain
Tissue specificity TISSUE SPECIFICITY: Plasma; synthesized in the liver.
Sequence
Sequence length 423
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Complement and coagulation cascades
Pancreatic secretion
Protein digestion and absorption 		  Metabolism of Angiotensinogen to Angiotensins
Regulation of Complement cascade
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)		 16959692
Show/Hide Text Mining Associations (66)
Associations from Text Mining
Disease Name Relationship Type References
Androgen Insensitivity Syndrome Associate 31755939
Antithrombin III Deficiency Inhibit 37201530
Aortic Aneurysm Abdominal Associate 22163325
Behcet Syndrome Associate 18341631
Blood Coagulation Disorders Associate 21933309, 31140594
Breast Neoplasms Inhibit 27221823
Carcinoma Small Cell Stimulate 15224354
Carcinoma Squamous Cell Associate 37442189
Cardiovascular Diseases Associate 18958767, 18974842, 19323787
Carotid Artery Thrombosis Associate 19323787, 19377074, 31781299