Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	135228
Gene name Gene Name - the full gene name approved by the HGNC.	CD109 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CD109
Synonyms (NCBI Gene) Gene synonyms aliases	CPAMD7, p180, r150
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020701	hsa-miR-155-5p	Proteomics	18668040
MIRT023686	hsa-miR-1-3p	Proteomics	18668040
MIRT023686	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT721115	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT721114	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT721113	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT721115	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT721114	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT721113	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT709006	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT709005	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709004	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709003	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT709002	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT873637	hsa-miR-122	CLIP-seq
MIRT873638	hsa-miR-1252	CLIP-seq
MIRT873639	hsa-miR-1253	CLIP-seq
MIRT873640	hsa-miR-1321	CLIP-seq
MIRT873641	hsa-miR-2117	CLIP-seq
MIRT873642	hsa-miR-214	CLIP-seq
MIRT873643	hsa-miR-3121-3p	CLIP-seq
MIRT873644	hsa-miR-3135b	CLIP-seq
MIRT873645	hsa-miR-3162-5p	CLIP-seq
MIRT873646	hsa-miR-3194-3p	CLIP-seq
MIRT873647	hsa-miR-320a	CLIP-seq
MIRT873648	hsa-miR-320b	CLIP-seq
MIRT873649	hsa-miR-320c	CLIP-seq
MIRT873650	hsa-miR-320d	CLIP-seq
MIRT873651	hsa-miR-361-3p	CLIP-seq
MIRT873652	hsa-miR-3619-5p	CLIP-seq
MIRT873653	hsa-miR-3652	CLIP-seq
MIRT873654	hsa-miR-3920	CLIP-seq
MIRT873655	hsa-miR-4274	CLIP-seq
MIRT873656	hsa-miR-4291	CLIP-seq
MIRT873657	hsa-miR-4311	CLIP-seq
MIRT873658	hsa-miR-4429	CLIP-seq
MIRT873659	hsa-miR-4430	CLIP-seq
MIRT873660	hsa-miR-4434	CLIP-seq
MIRT873661	hsa-miR-4516	CLIP-seq
MIRT873662	hsa-miR-4521	CLIP-seq
MIRT873663	hsa-miR-4684-5p	CLIP-seq
MIRT873664	hsa-miR-4695-3p	CLIP-seq
MIRT873665	hsa-miR-4739	CLIP-seq
MIRT873666	hsa-miR-4756-5p	CLIP-seq
MIRT873667	hsa-miR-4789-3p	CLIP-seq
MIRT873668	hsa-miR-4799-5p	CLIP-seq
MIRT873669	hsa-miR-515-5p	CLIP-seq
MIRT873670	hsa-miR-539	CLIP-seq
MIRT873671	hsa-miR-654-3p	CLIP-seq
MIRT873672	hsa-miR-761	CLIP-seq
MIRT873673	hsa-miR-922	CLIP-seq
MIRT873640	hsa-miR-1321	CLIP-seq
MIRT873645	hsa-miR-3162-5p	CLIP-seq
MIRT873646	hsa-miR-3194-3p	CLIP-seq
MIRT739427	hsa-miR-3664-3p	CLIP-seq
MIRT739428	hsa-miR-3907	CLIP-seq
MIRT873654	hsa-miR-3920	CLIP-seq
MIRT873674	hsa-miR-4715-3p	CLIP-seq
MIRT873675	hsa-miR-4731-5p	CLIP-seq
MIRT873676	hsa-miR-4738-3p	CLIP-seq
MIRT873665	hsa-miR-4739	CLIP-seq
MIRT873666	hsa-miR-4756-5p	CLIP-seq
MIRT873677	hsa-miR-4757-5p	CLIP-seq
MIRT873678	hsa-miR-4766-5p	CLIP-seq
MIRT873679	hsa-miR-4794	CLIP-seq
MIRT873680	hsa-miR-512-3p	CLIP-seq
MIRT873681	hsa-miR-513a-3p	CLIP-seq
MIRT873669	hsa-miR-515-5p	CLIP-seq
MIRT873670	hsa-miR-539	CLIP-seq
MIRT739426	hsa-miR-542-5p	CLIP-seq
MIRT873682	hsa-miR-759	CLIP-seq
MIRT739427	hsa-miR-3664-3p	CLIP-seq
MIRT739428	hsa-miR-3907	CLIP-seq
MIRT739426	hsa-miR-542-5p	CLIP-seq
MIRT1959161	hsa-miR-1243	CLIP-seq
MIRT1959162	hsa-miR-3654	CLIP-seq
MIRT873681	hsa-miR-513a-3p	CLIP-seq
MIRT1959163	hsa-miR-3120-5p	CLIP-seq
MIRT739427	hsa-miR-3664-3p	CLIP-seq
MIRT739428	hsa-miR-3907	CLIP-seq
MIRT873676	hsa-miR-4738-3p	CLIP-seq
MIRT873678	hsa-miR-4766-5p	CLIP-seq
MIRT739426	hsa-miR-542-5p	CLIP-seq
MIRT1959164	hsa-miR-548n	CLIP-seq
MIRT1959165	hsa-miR-548t	CLIP-seq
MIRT873682	hsa-miR-759	CLIP-seq
MIRT2196098	hsa-miR-4438	CLIP-seq
MIRT2196099	hsa-miR-5095	CLIP-seq
MIRT2196100	hsa-miR-101	CLIP-seq
MIRT873637	hsa-miR-122	CLIP-seq
MIRT2196101	hsa-miR-1286	CLIP-seq
MIRT2196102	hsa-miR-144	CLIP-seq
MIRT873644	hsa-miR-3135b	CLIP-seq
MIRT2196103	hsa-miR-3149	CLIP-seq
MIRT2196104	hsa-miR-3170	CLIP-seq
MIRT2196105	hsa-miR-342-5p	CLIP-seq
MIRT873651	hsa-miR-361-3p	CLIP-seq
MIRT873653	hsa-miR-3652	CLIP-seq
MIRT739427	hsa-miR-3664-3p	CLIP-seq
MIRT2196106	hsa-miR-3664-5p	CLIP-seq
MIRT2196107	hsa-miR-3940-5p	CLIP-seq
MIRT2196108	hsa-miR-3944-5p	CLIP-seq
MIRT2196109	hsa-miR-4252	CLIP-seq
MIRT2196110	hsa-miR-4284	CLIP-seq
MIRT873659	hsa-miR-4430	CLIP-seq
MIRT2196098	hsa-miR-4438	CLIP-seq
MIRT2196111	hsa-miR-4507	CLIP-seq
MIRT2196112	hsa-miR-4639-3p	CLIP-seq
MIRT2196113	hsa-miR-4651	CLIP-seq
MIRT2196114	hsa-miR-4664-5p	CLIP-seq
MIRT873664	hsa-miR-4695-3p	CLIP-seq
MIRT2196115	hsa-miR-4716-5p	CLIP-seq
MIRT2196116	hsa-miR-4722-5p	CLIP-seq
MIRT873675	hsa-miR-4731-5p	CLIP-seq
MIRT2196099	hsa-miR-5095	CLIP-seq
MIRT873680	hsa-miR-512-3p	CLIP-seq
MIRT739426	hsa-miR-542-5p	CLIP-seq
MIRT2196117	hsa-miR-587	CLIP-seq
MIRT2196118	hsa-miR-608	CLIP-seq
MIRT873682	hsa-miR-759	CLIP-seq
MIRT2385726	hsa-miR-4436b-5p	CLIP-seq
MIRT873641	hsa-miR-2117	CLIP-seq
MIRT2436171	hsa-miR-4475	CLIP-seq
MIRT873662	hsa-miR-4521	CLIP-seq
MIRT873663	hsa-miR-4684-5p	CLIP-seq
MIRT873641	hsa-miR-2117	CLIP-seq
MIRT2436171	hsa-miR-4475	CLIP-seq
MIRT873662	hsa-miR-4521	CLIP-seq
MIRT873663	hsa-miR-4684-5p	CLIP-seq
MIRT2499149	hsa-miR-1185	CLIP-seq
MIRT873637	hsa-miR-122	CLIP-seq
MIRT2499150	hsa-miR-1228	CLIP-seq
MIRT2499151	hsa-miR-1229	CLIP-seq
MIRT873638	hsa-miR-1252	CLIP-seq
MIRT2499152	hsa-miR-1265	CLIP-seq
MIRT2499153	hsa-miR-128	CLIP-seq
MIRT2499154	hsa-miR-1283	CLIP-seq
MIRT2499155	hsa-miR-1307	CLIP-seq
MIRT2499156	hsa-miR-138	CLIP-seq
MIRT2196102	hsa-miR-144	CLIP-seq
MIRT2499157	hsa-miR-149	CLIP-seq
MIRT2499158	hsa-miR-188-5p	CLIP-seq
MIRT2499159	hsa-miR-1915	CLIP-seq
MIRT2499160	hsa-miR-1976	CLIP-seq
MIRT2499161	hsa-miR-24	CLIP-seq
MIRT2499162	hsa-miR-27a	CLIP-seq
MIRT2499163	hsa-miR-27b	CLIP-seq
MIRT2499164	hsa-miR-299-3p	CLIP-seq
MIRT2499165	hsa-miR-3065-3p	CLIP-seq
MIRT1959163	hsa-miR-3120-5p	CLIP-seq
MIRT873643	hsa-miR-3121-3p	CLIP-seq
MIRT873644	hsa-miR-3135b	CLIP-seq
MIRT2499166	hsa-miR-3151	CLIP-seq
MIRT2499167	hsa-miR-3156-5p	CLIP-seq
MIRT2499168	hsa-miR-3163	CLIP-seq
MIRT2499169	hsa-miR-3199	CLIP-seq
MIRT2499170	hsa-miR-3605-5p	CLIP-seq
MIRT2499171	hsa-miR-3613-5p	CLIP-seq
MIRT873651	hsa-miR-361-3p	CLIP-seq
MIRT2499172	hsa-miR-3647-3p	CLIP-seq
MIRT2499173	hsa-miR-3650	CLIP-seq
MIRT873653	hsa-miR-3652	CLIP-seq
MIRT2499174	hsa-miR-3662	CLIP-seq
MIRT2499175	hsa-miR-3663-5p	CLIP-seq
MIRT2499176	hsa-miR-3679-5p	CLIP-seq
MIRT2499177	hsa-miR-3692	CLIP-seq
MIRT2499178	hsa-miR-3713	CLIP-seq
MIRT2499179	hsa-miR-3926	CLIP-seq
MIRT2499180	hsa-miR-4283	CLIP-seq
MIRT2196110	hsa-miR-4284	CLIP-seq
MIRT2499181	hsa-miR-4287	CLIP-seq
MIRT873656	hsa-miR-4291	CLIP-seq
MIRT2499182	hsa-miR-4292	CLIP-seq
MIRT2499183	hsa-miR-4308	CLIP-seq
MIRT2499184	hsa-miR-4310	CLIP-seq
MIRT2499185	hsa-miR-4428	CLIP-seq
MIRT873659	hsa-miR-4430	CLIP-seq
MIRT2196098	hsa-miR-4438	CLIP-seq
MIRT2499186	hsa-miR-4447	CLIP-seq
MIRT2499187	hsa-miR-4469	CLIP-seq
MIRT2499188	hsa-miR-4472	CLIP-seq
MIRT2499189	hsa-miR-4487	CLIP-seq
MIRT2499190	hsa-miR-4489	CLIP-seq
MIRT2499191	hsa-miR-4533	CLIP-seq
MIRT2499192	hsa-miR-4539	CLIP-seq
MIRT2499193	hsa-miR-4635	CLIP-seq
MIRT2499194	hsa-miR-4638-5p	CLIP-seq
MIRT2499195	hsa-miR-4645-3p	CLIP-seq
MIRT2499196	hsa-miR-4648	CLIP-seq
MIRT2499197	hsa-miR-4654	CLIP-seq
MIRT2499198	hsa-miR-4656	CLIP-seq
MIRT2499199	hsa-miR-4661-3p	CLIP-seq
MIRT2499200	hsa-miR-4668-3p	CLIP-seq
MIRT2499201	hsa-miR-4685-3p	CLIP-seq
MIRT2499202	hsa-miR-4685-5p	CLIP-seq
MIRT2499203	hsa-miR-4694-3p	CLIP-seq
MIRT873664	hsa-miR-4695-3p	CLIP-seq
MIRT873674	hsa-miR-4715-3p	CLIP-seq
MIRT2499204	hsa-miR-4724-5p	CLIP-seq
MIRT2499205	hsa-miR-4747-5p	CLIP-seq
MIRT2499206	hsa-miR-4755-3p	CLIP-seq
MIRT2499207	hsa-miR-4764-5p	CLIP-seq
MIRT2499208	hsa-miR-4769-5p	CLIP-seq
MIRT2499209	hsa-miR-4772-3p	CLIP-seq
MIRT873679	hsa-miR-4794	CLIP-seq
MIRT873668	hsa-miR-4799-5p	CLIP-seq
MIRT2499210	hsa-miR-4802-3p	CLIP-seq
MIRT2499211	hsa-miR-491-5p	CLIP-seq
MIRT2196099	hsa-miR-5095	CLIP-seq
MIRT2499212	hsa-miR-522	CLIP-seq
MIRT2499213	hsa-miR-548s	CLIP-seq
MIRT2499214	hsa-miR-552	CLIP-seq
MIRT2499215	hsa-miR-561	CLIP-seq
MIRT2499216	hsa-miR-577	CLIP-seq
MIRT2499217	hsa-miR-593	CLIP-seq
MIRT2499218	hsa-miR-601	CLIP-seq
MIRT2499219	hsa-miR-630	CLIP-seq
MIRT2499220	hsa-miR-7	CLIP-seq
MIRT2499221	hsa-miR-764	CLIP-seq
MIRT873637	hsa-miR-122	CLIP-seq
MIRT2499150	hsa-miR-1228	CLIP-seq
MIRT873638	hsa-miR-1252	CLIP-seq
MIRT2677637	hsa-miR-1266	CLIP-seq
MIRT2499153	hsa-miR-128	CLIP-seq
MIRT2677638	hsa-miR-1297	CLIP-seq
MIRT2499155	hsa-miR-1307	CLIP-seq
MIRT2499157	hsa-miR-149	CLIP-seq
MIRT2499158	hsa-miR-188-5p	CLIP-seq
MIRT2499160	hsa-miR-1976	CLIP-seq
MIRT873642	hsa-miR-214	CLIP-seq
MIRT2499161	hsa-miR-24	CLIP-seq
MIRT2677639	hsa-miR-26a	CLIP-seq
MIRT2677640	hsa-miR-26b	CLIP-seq
MIRT2499162	hsa-miR-27a	CLIP-seq
MIRT2499163	hsa-miR-27b	CLIP-seq
MIRT1959163	hsa-miR-3120-5p	CLIP-seq
MIRT873644	hsa-miR-3135b	CLIP-seq
MIRT2677641	hsa-miR-3154	CLIP-seq
MIRT873646	hsa-miR-3194-3p	CLIP-seq
MIRT2499169	hsa-miR-3199	CLIP-seq
MIRT2499171	hsa-miR-3613-5p	CLIP-seq
MIRT873651	hsa-miR-361-3p	CLIP-seq
MIRT873652	hsa-miR-3619-5p	CLIP-seq
MIRT2499172	hsa-miR-3647-3p	CLIP-seq
MIRT873653	hsa-miR-3652	CLIP-seq
MIRT2499175	hsa-miR-3663-5p	CLIP-seq
MIRT739427	hsa-miR-3664-3p	CLIP-seq
MIRT2499177	hsa-miR-3692	CLIP-seq
MIRT2499178	hsa-miR-3713	CLIP-seq
MIRT873654	hsa-miR-3920	CLIP-seq
MIRT2499179	hsa-miR-3926	CLIP-seq
MIRT873655	hsa-miR-4274	CLIP-seq
MIRT2677642	hsa-miR-4279	CLIP-seq
MIRT2196110	hsa-miR-4284	CLIP-seq
MIRT2499181	hsa-miR-4287	CLIP-seq
MIRT873656	hsa-miR-4291	CLIP-seq
MIRT2499182	hsa-miR-4292	CLIP-seq
MIRT2499183	hsa-miR-4308	CLIP-seq
MIRT873659	hsa-miR-4430	CLIP-seq
MIRT2196098	hsa-miR-4438	CLIP-seq
MIRT2677643	hsa-miR-4465	CLIP-seq
MIRT2499187	hsa-miR-4469	CLIP-seq
MIRT2677644	hsa-miR-4518	CLIP-seq
MIRT2499192	hsa-miR-4539	CLIP-seq
MIRT2499193	hsa-miR-4635	CLIP-seq
MIRT2499194	hsa-miR-4638-5p	CLIP-seq
MIRT2499199	hsa-miR-4661-3p	CLIP-seq
MIRT2499200	hsa-miR-4668-3p	CLIP-seq
MIRT2499201	hsa-miR-4685-3p	CLIP-seq
MIRT873664	hsa-miR-4695-3p	CLIP-seq
MIRT873674	hsa-miR-4715-3p	CLIP-seq
MIRT2499204	hsa-miR-4724-5p	CLIP-seq
MIRT2499206	hsa-miR-4755-3p	CLIP-seq
MIRT2499209	hsa-miR-4772-3p	CLIP-seq
MIRT873667	hsa-miR-4789-3p	CLIP-seq
MIRT873679	hsa-miR-4794	CLIP-seq
MIRT873668	hsa-miR-4799-5p	CLIP-seq
MIRT2196099	hsa-miR-5095	CLIP-seq
MIRT2499213	hsa-miR-548s	CLIP-seq
MIRT2499214	hsa-miR-552	CLIP-seq
MIRT2499215	hsa-miR-561	CLIP-seq
MIRT2499216	hsa-miR-577	CLIP-seq
MIRT2499217	hsa-miR-593	CLIP-seq
MIRT2499218	hsa-miR-601	CLIP-seq
MIRT2677645	hsa-miR-642b	CLIP-seq
MIRT873672	hsa-miR-761	CLIP-seq
MIRT2499221	hsa-miR-764	CLIP-seq
MIRT873673	hsa-miR-922	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001942	Process	Hair follicle development	IEA
GO:0004866	Function	Endopeptidase inhibitor activity	IEA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0009986	Component	Cell surface	HDA	19581412
GO:0010839	Process	Negative regulation of keratinocyte proliferation	IEA
GO:0016020	Component	Membrane	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IDA	16754747
GO:0031092	Component	Platelet alpha granule membrane	TAS
GO:0043616	Process	Keratinocyte proliferation	IEA
GO:0045616	Process	Regulation of keratinocyte differentiation	IEA
GO:0061045	Process	Negative regulation of wound healing	IDA	16754747
GO:0072089	Process	Stem cell proliferation	IEA
GO:0072675	Process	Osteoclast fusion	IEA
GO:0098552	Component	Side of membrane	IEA
GO:2000647	Process	Negative regulation of stem cell proliferation	IEA

MIM	HGNC	e!Ensembl
608859	21685	ENSG00000156535

Protein

UniProt ID

Q6YHK3

Protein name

CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)

Protein function

Modulates negatively TGFB1 signaling in keratinocytes.

PDB

8S3O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01835	MG2	130 → 221	MG2 domain	Domain
PF17791	MG3	223 → 302	Macroglobulin domain MG3	Domain
PF07703	A2M_BRD	468 → 599	Alpha-2-macroglobulin bait region domain	Domain
PF00207	A2M	693 → 784	Alpha-2-macroglobulin family	Family
PF07678	TED_complement	897 → 1194	A-macroglobulin TED domain	Domain
PF07677	A2M_recep	1311 → 1395	A-macroglobulin receptor binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endot

Sequence

MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKA
ELLKTASNLTVSVLEAEGVFEKGSFKTLTLPSLPLNSADEIYELRVTGRTQDEILFSNST
RLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKDPKSNLIQQWL
SQQSDLGVISKTFQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPKFEVTLQTPLYCS
MNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKNITKTFKINGSANFSFNDEEMK
NVMDSSNGLSEYLDLSSPGPVEILTTVTESVTGISRNVSTNVFFKQHDYIIEFFDYTTVL
KPSLNFTATVKVTRADGNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQKINY
TVPQSGTFKIEFPILEDSSELQLKAYFLGSKSSMAVHSLFKSPSKTYIQLKTRDENIKVG
SPFELVVSGNKRLKELSYMVVSRGQLVAVGKQNSTMFSLTPENSWTPKACVIVYYIEDDG
EIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMN
ASNDITMENVVHELELYNTGYYLGMFMNSFAVFQECGLWVLTDANLTKDYIDGVYDNAEY
AERFMEENEGHIVDIHDFSLGSSPHVRKHFPETWIWLDTNMGYRIYQEFEVTVPDSITSW
VATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEV
KVIIEKSDKFDILMTSNEINATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPT
ASDAVTQMILVKAEGIEKSYSQSILLDLTDNRLQSTLKTLSFSFPPNTVTGSERVQITAI
GDVLGPSINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQG
YQRELLYQREDGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGH
QKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNIDVQESIHFLESEFS
RGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVSSESKLSDSWQPRSL
DIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEFAALMNT
ERTNIQVTVTGPSSPSPVKFLIDTHNRLLLQTAELAVVQPTAVNISANGFGFAICQLNVV
YNVKASGSSRRRRSIQNQEAFDLDVAVKENKDDLNHVDLNVCTSFSGPGRSGMALMEVNL
LSGFMVPSEAISLSETVKKVEYDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVS
IVDYYEPRRQAVRSYNSEVKLSSCDLCSDVQGCRPCEDGASGSHHHSSVIFIFCFKLLYF
MELWL

Sequence length

1445

Interactions

View interactions

	Reactome
			Platelet degranulation Post-translational modification: synthesis of GPI-anchored proteins

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Carcinoma	Basal cell carcinoma	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Endometriosis	Endometriosis	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Otosclerosis	Otosclerosis	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Show/Hide Text Mining Associations (31)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Bone Diseases Metabolic	Associate	29100095
Brain Neoplasms	Associate	33469081
Breast Neoplasms	Associate	20035377, 25149155, 25506915
Carcinogenesis	Associate	19016750
Carcinoma Adenosquamous	Associate	26249215
Carcinoma Pancreatic Ductal	Associate	36907523
Carcinoma Squamous Cell	Stimulate	19016750
Carcinoma Squamous Cell	Associate	26249215, 31695056
Cerebellar Diseases	Associate	29100095
Colorectal Neoplasms	Associate	21278247, 23975090
Developmental Disabilities	Associate	29100095
Dyskinesias	Associate	19016750
Glioblastoma	Associate	25506915, 30759398
Glioma	Associate	37056564
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25149155
Leukemia Myeloid Acute	Associate	31015209
Medulloblastoma	Associate	33469081
Mouth Diseases	Associate	19016750
Mouth Neoplasms	Associate	19016750
Neoplasm Metastasis	Associate	22813880
Neoplasms	Associate	24376795, 25506915, 30759398, 31015209, 31695056, 33110154, 36907523
Neoplasms	Stimulate	37030166
Osteosarcoma	Associate	37030166
Pancreatic Neoplasms	Associate	36907523
Prostate Cancer Hereditary 7	Associate	37476073
Prostatic Neoplasms Castration Resistant	Associate	37476073
Sarcoma	Associate	24376795
Stomach Neoplasms	Associate	30702489
Thrombocytopenia Neonatal Alloimmune	Associate	11861285
Transfusion Reaction	Associate	11861285
Triple Negative Breast Neoplasms	Stimulate	25149155

CD109 (CD109 molecule)