Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
134
Gene name Gene Name - the full gene name approved by the HGNC.
Adenosine A1 receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADORA1
Synonyms (NCBI Gene) Gene synonyms aliases
RDC7
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT769574 hsa-miR-1205 CLIP-seq
MIRT769575 hsa-miR-1249 CLIP-seq
MIRT769576 hsa-miR-188-3p CLIP-seq
MIRT769577 hsa-miR-1909 CLIP-seq
MIRT769578 hsa-miR-1915 CLIP-seq
Transcription factors
Transcription factor Regulation Reference
NFKB1 Activation 9547356
RELA Activation 9547356
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000186 Process Activation of MAPKK activity IEA
GO:0001609 Function G protein-coupled adenosine receptor activity IEA
GO:0001659 Process Temperature homeostasis IEA
GO:0001664 Function G protein-coupled receptor binding IEA
GO:0001666 Process Response to hypoxia IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
102775 262 ENSG00000163485
Protein
UniProt ID P30542
Protein name Adenosine receptor A1
Protein function Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
PDB 5N2S , 5UEN , 6D9H , 7LD3 , 7LD4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 26 288 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 326
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Regulation of lipolysis in adipocytes
Renin secretion
Morphine addiction
  Adenosine P1 receptors
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
19820430
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma, Childhood asthma 30929738, 31619474, 27182965, 31036433 ClinVar, GWAS
Myocardial infarction Myocardial Infarction 12160945 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Stimulate 18241242
Anxiety Associate 24943643, 33235193
Anxiety Disorders Associate 26317759
Arthritis Psoriatic Associate 39684939
Asthma Associate 36818476
Asthma Aspirin Induced Associate 19019667
Atrial Fibrillation Associate 27462069
Attention Deficit Disorder with Hyperactivity Associate 26317759
Brain Injuries Traumatic Associate 20609566
Breast Neoplasms Associate 19935720, 28971320, 32777015, 33096318