Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
133121
Gene name Gene Name - the full gene name approved by the HGNC.
Ectonucleotide pyrophosphatase/phosphodiesterase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ENPP6
Synonyms (NCBI Gene) Gene synonyms aliases
NPP6
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q35.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019285 hsa-miR-148b-3p Microarray 17612493
MIRT509884 hsa-miR-6512-5p PAR-CLIP 20371350
MIRT509883 hsa-miR-506-5p PAR-CLIP 20371350
MIRT509882 hsa-miR-4436a PAR-CLIP 20371350
MIRT509881 hsa-miR-5000-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IDA 15788404
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane IDA 15788404
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616983 23409 ENSG00000164303
Protein
UniProt ID Q6UWR7
Protein name Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)
Protein function Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404). Has a preference for LPC with short (12:0 and 14:0) or p
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01663 Phosphodiest 26 357 Type I phosphodiesterase / nucleotide pyrophosphatase Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). {ECO:0000269|PubMed:15788404}.
Sequence
Sequence length 440
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ether lipid metabolism
Metabolic pathways
  Glycerophospholipid catabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Insomnia Insomnia GWAS
Ischemic Stroke Ischemic Stroke GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 36776048