Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	132625
Gene name Gene Name - the full gene name approved by the HGNC.	ZFP42 zinc finger protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ZFP42
Synonyms (NCBI Gene) Gene synonyms aliases	REX-1, REX1, ZNF754, zfp-42
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q35.2

Show/Hide all(124)

miRTarBase ID	miRNA	Experiments	Reference
MIRT530012	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT530011	hsa-miR-5692b	PAR-CLIP	22012620
MIRT530010	hsa-miR-5692c	PAR-CLIP	22012620
MIRT530009	hsa-miR-323b-3p	PAR-CLIP	22012620
MIRT458359	hsa-miR-4704-5p	PAR-CLIP	23592263
MIRT458358	hsa-miR-3117-5p	PAR-CLIP	23592263
MIRT458357	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT458357	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT530012	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT530011	hsa-miR-5692b	PAR-CLIP	22012620
MIRT530010	hsa-miR-5692c	PAR-CLIP	22012620
MIRT530009	hsa-miR-323b-3p	PAR-CLIP	22012620
MIRT458359	hsa-miR-4704-5p	PAR-CLIP	23592263
MIRT458358	hsa-miR-3117-5p	PAR-CLIP	23592263
MIRT458357	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT1511675	hsa-miR-1183	CLIP-seq
MIRT1511676	hsa-miR-1208	CLIP-seq
MIRT1511677	hsa-miR-129-5p	CLIP-seq
MIRT1511678	hsa-miR-154	CLIP-seq
MIRT1511679	hsa-miR-3123	CLIP-seq
MIRT1511680	hsa-miR-3137	CLIP-seq
MIRT1511681	hsa-miR-34b	CLIP-seq
MIRT1511682	hsa-miR-3614-5p	CLIP-seq
MIRT1511683	hsa-miR-3672	CLIP-seq
MIRT1511684	hsa-miR-3674	CLIP-seq
MIRT1511685	hsa-miR-371-5p	CLIP-seq
MIRT1511686	hsa-miR-3919	CLIP-seq
MIRT1511687	hsa-miR-4433	CLIP-seq
MIRT1511688	hsa-miR-4459	CLIP-seq
MIRT1511689	hsa-miR-4695-3p	CLIP-seq
MIRT1511690	hsa-miR-4705	CLIP-seq
MIRT1511691	hsa-miR-4732-5p	CLIP-seq
MIRT1511692	hsa-miR-4768-3p	CLIP-seq
MIRT1511693	hsa-miR-493	CLIP-seq
MIRT1511694	hsa-miR-541	CLIP-seq
MIRT1511695	hsa-miR-654-5p	CLIP-seq
MIRT1511675	hsa-miR-1183	CLIP-seq
MIRT1511676	hsa-miR-1208	CLIP-seq
MIRT2154031	hsa-miR-1228	CLIP-seq
MIRT2154032	hsa-miR-2114	CLIP-seq
MIRT1511679	hsa-miR-3123	CLIP-seq
MIRT1511680	hsa-miR-3137	CLIP-seq
MIRT2154033	hsa-miR-329	CLIP-seq
MIRT1511681	hsa-miR-34b	CLIP-seq
MIRT1511682	hsa-miR-3614-5p	CLIP-seq
MIRT2154034	hsa-miR-362-3p	CLIP-seq
MIRT1511684	hsa-miR-3674	CLIP-seq
MIRT2154035	hsa-miR-3689a-3p	CLIP-seq
MIRT2154036	hsa-miR-3689c	CLIP-seq
MIRT1511686	hsa-miR-3919	CLIP-seq
MIRT2154037	hsa-miR-4649-3p	CLIP-seq
MIRT1511689	hsa-miR-4695-3p	CLIP-seq
MIRT2154038	hsa-miR-4704-3p	CLIP-seq
MIRT1511690	hsa-miR-4705	CLIP-seq
MIRT2154039	hsa-miR-4711-5p	CLIP-seq
MIRT2154040	hsa-miR-4728-5p	CLIP-seq
MIRT1511691	hsa-miR-4732-5p	CLIP-seq
MIRT2154041	hsa-miR-4781-3p	CLIP-seq
MIRT2154042	hsa-miR-485-5p	CLIP-seq
MIRT2154043	hsa-miR-516b	CLIP-seq
MIRT2154044	hsa-miR-642b	CLIP-seq
MIRT2154045	hsa-miR-890	CLIP-seq
MIRT1511675	hsa-miR-1183	CLIP-seq
MIRT1511676	hsa-miR-1208	CLIP-seq
MIRT2154031	hsa-miR-1228	CLIP-seq
MIRT2154032	hsa-miR-2114	CLIP-seq
MIRT2374241	hsa-miR-3122	CLIP-seq
MIRT1511679	hsa-miR-3123	CLIP-seq
MIRT1511680	hsa-miR-3137	CLIP-seq
MIRT2374242	hsa-miR-342-3p	CLIP-seq
MIRT1511681	hsa-miR-34b	CLIP-seq
MIRT1511682	hsa-miR-3614-5p	CLIP-seq
MIRT1511683	hsa-miR-3672	CLIP-seq
MIRT2154035	hsa-miR-3689a-3p	CLIP-seq
MIRT2154036	hsa-miR-3689c	CLIP-seq
MIRT1511685	hsa-miR-371-5p	CLIP-seq
MIRT2374243	hsa-miR-3913-5p	CLIP-seq
MIRT1511686	hsa-miR-3919	CLIP-seq
MIRT2374244	hsa-miR-3929	CLIP-seq
MIRT2374245	hsa-miR-4419b	CLIP-seq
MIRT2374246	hsa-miR-4478	CLIP-seq
MIRT2154037	hsa-miR-4649-3p	CLIP-seq
MIRT1511690	hsa-miR-4705	CLIP-seq
MIRT2154040	hsa-miR-4728-5p	CLIP-seq
MIRT2154042	hsa-miR-485-5p	CLIP-seq
MIRT2154043	hsa-miR-516b	CLIP-seq
MIRT1511694	hsa-miR-541	CLIP-seq
MIRT2374247	hsa-miR-622	CLIP-seq
MIRT2154044	hsa-miR-642b	CLIP-seq
MIRT1511695	hsa-miR-654-5p	CLIP-seq
MIRT2154045	hsa-miR-890	CLIP-seq
MIRT2154031	hsa-miR-1228	CLIP-seq
MIRT2463944	hsa-miR-1268	CLIP-seq
MIRT2463945	hsa-miR-1268b	CLIP-seq
MIRT2463946	hsa-miR-3675-3p	CLIP-seq
MIRT2463947	hsa-miR-4684-5p	CLIP-seq
MIRT2463948	hsa-miR-548c-3p	CLIP-seq
MIRT2154031	hsa-miR-1228	CLIP-seq
MIRT2463944	hsa-miR-1268	CLIP-seq
MIRT2463945	hsa-miR-1268b	CLIP-seq
MIRT2374241	hsa-miR-3122	CLIP-seq
MIRT2463946	hsa-miR-3675-3p	CLIP-seq
MIRT2154035	hsa-miR-3689a-3p	CLIP-seq
MIRT2154036	hsa-miR-3689c	CLIP-seq
MIRT2374243	hsa-miR-3913-5p	CLIP-seq
MIRT2463947	hsa-miR-4684-5p	CLIP-seq
MIRT2154040	hsa-miR-4728-5p	CLIP-seq
MIRT1511694	hsa-miR-541	CLIP-seq
MIRT2463948	hsa-miR-548c-3p	CLIP-seq
MIRT1511695	hsa-miR-654-5p	CLIP-seq
MIRT2154031	hsa-miR-1228	CLIP-seq
MIRT2463944	hsa-miR-1268	CLIP-seq
MIRT2463945	hsa-miR-1268b	CLIP-seq
MIRT2374241	hsa-miR-3122	CLIP-seq
MIRT1511683	hsa-miR-3672	CLIP-seq
MIRT2463946	hsa-miR-3675-3p	CLIP-seq
MIRT2154035	hsa-miR-3689a-3p	CLIP-seq
MIRT2154036	hsa-miR-3689c	CLIP-seq
MIRT2374243	hsa-miR-3913-5p	CLIP-seq
MIRT2463947	hsa-miR-4684-5p	CLIP-seq
MIRT2154040	hsa-miR-4728-5p	CLIP-seq
MIRT1511694	hsa-miR-541	CLIP-seq
MIRT2463948	hsa-miR-548c-3p	CLIP-seq
MIRT1511695	hsa-miR-654-5p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
POU5F1	Activation	17068183

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0003700	Function	DNA-binding transcription factor activity	NAS	14688391
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005667	Component	Transcription regulator complex	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	16344273, 18281244
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008584	Process	Male gonad development	IEP	18281244
GO:0008585	Process	Female gonad development	IEP	18281244
GO:0031519	Component	PcG protein complex	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0051321	Process	Meiotic cell cycle	NAS	18281244
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
614572	30949	ENSG00000179059

Protein

UniProt ID

Q96MM3

Protein name

Zinc finger protein 42 homolog (Zfp-42) (Reduced expression protein 1) (REX-1) (hREX-1) (Zinc finger protein 754)

Protein function

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cel

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00096	zf-C2H2	217 → 239	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	245 → 269	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	275 → 299	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed

Sequence

MSQQLKKRAKTRHQKGLGGRAPSGAKPRQGKSSQDLQAEIEPVSAVWALCDGYVCYEPGP
QALGGDDFSDCYIECVIRGEFSQPILEEDSLFESLEYLKKGSEQQLSQKVFEASSLECSL
EYMKKGVKKELPQKIVGENSLEYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARKKPPINK
EYDSLSAIACPQSGCTRKLRNRAALRKHLLIHGPRDHVCAECGKAFVESSKLKRHFLVHT
GEKPFRCTFEGCGKRFSLDFNLRTHVRIHTGEKRFVCPFQGCNRRFIQSNNLKAHILTHA
NTNKNEQEGK

Sequence length

310

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor		GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.	GWAS, CBGDA

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Beckwith Wiedemann Syndrome	Associate	30221575
Birk Barel Mental Retardation Dysmorphism Syndrome	Associate	30221575
Carcinoma Renal Cell	Associate	22610075
Carcinoma Squamous Cell	Stimulate	21446939
Colorectal Neoplasms	Associate	38092774
Endometriosis	Associate	19690622
Lung Neoplasms	Associate	37563730
Neoplasms	Stimulate	21446939
Neoplasms	Associate	27729459, 32430478, 34183450, 37563730
Prostatic Neoplasms	Associate	20232320, 34183450
Prostatitis	Associate	34183450
Squamous Cell Carcinoma of Head and Neck	Associate	34406843
Teratocarcinoma	Inhibit	20232320

ZFP42 (ZFP42 zinc finger protein)