Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	131405
Gene name	Tripartite motif containing 71
Gene symbol	TRIM71
Synonyms (NCBI Gene)	HYC4HYDCC1LIN-41LIN41
Chromosome	3
Chromosome location	3p22.3
Summary	The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1045177462	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1575362216	G>A	Pathogenic	Missense variant, coding sequence variant
rs1575362239	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1575362492	G>A	Pathogenic	Missense variant, coding sequence variant

253

Show/Hide all (253)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002077	hsa-let-7a-5p	Luciferase reporter assay	17890240
MIRT002077	hsa-let-7a-5p	Luciferase reporter assay	17890240
MIRT002076	hsa-let-7c-5p	Luciferase reporter assay	17890240
MIRT002076	hsa-let-7c-5p	Luciferase reporter assay	17890240
MIRT002077	hsa-let-7a-5p	Luciferase reporter assay	18829576
MIRT006740	hsa-miR-125b-5p	ImmunoblotNorthern blot	15722555
MIRT002077	hsa-let-7a-5p	ImmunoblotNorthern blot	15722555
MIRT002076	hsa-let-7c-5p	Reporter assay;Other	17890240
MIRT002077	hsa-let-7a-5p	Reporter assay	17890240
MIRT051040	hsa-miR-17-5p	CLASH	23622248
MIRT641833	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641831	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT652155	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT652154	hsa-miR-4679	HITS-CLIP	23824327
MIRT652153	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT652152	hsa-miR-4770	HITS-CLIP	23824327
MIRT652151	hsa-miR-6088	HITS-CLIP	23824327
MIRT652150	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT652149	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641830	hsa-miR-655-5p	HITS-CLIP	23824327
MIRT641829	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT641828	hsa-miR-6086	HITS-CLIP	23824327
MIRT652148	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT641827	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT652147	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT652146	hsa-miR-133a-3p	HITS-CLIP	23824327
MIRT652145	hsa-miR-133b	HITS-CLIP	23824327
MIRT641833	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641832	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641831	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT641830	hsa-miR-655-5p	HITS-CLIP	23824327
MIRT641829	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT641828	hsa-miR-6086	HITS-CLIP	23824327
MIRT641827	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT243480	hsa-miR-4500	PAR-CLIP	20371350
MIRT002076	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT243471	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT243472	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT243475	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT243473	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT243477	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT002077	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT243476	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT243479	hsa-miR-4458	PAR-CLIP	20371350
MIRT243474	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT355451	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT243489	hsa-miR-5680	PAR-CLIP	20371350
MIRT243482	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT243490	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT565225	hsa-miR-34c-3p	PAR-CLIP	20371350
MIRT243485	hsa-miR-4495	PAR-CLIP	20371350
MIRT565224	hsa-miR-203a-3p	PAR-CLIP	20371350
MIRT407940	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT565223	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT243488	hsa-miR-5093	PAR-CLIP	20371350
MIRT243483	hsa-miR-3935	PAR-CLIP	20371350
MIRT255609	hsa-miR-3908	PAR-CLIP	22012620
MIRT255611	hsa-miR-4759	PAR-CLIP	22012620
MIRT255607	hsa-miR-3169	PAR-CLIP	22012620
MIRT255613	hsa-miR-8083	PAR-CLIP	22012620
MIRT243478	hsa-miR-3607-3p	PAR-CLIP	22012620
MIRT533513	hsa-miR-6792-5p	PAR-CLIP	22012620
MIRT255606	hsa-miR-3117-3p	PAR-CLIP	22012620
MIRT533512	hsa-miR-452-3p	PAR-CLIP	22012620
MIRT533511	hsa-miR-3686	PAR-CLIP	22012620
MIRT255610	hsa-miR-4503	PAR-CLIP	22012620
MIRT533510	hsa-miR-1276	PAR-CLIP	22012620
MIRT533509	hsa-miR-2278	PAR-CLIP	22012620
MIRT533508	hsa-miR-1298-3p	PAR-CLIP	22012620
MIRT533507	hsa-miR-4667-5p	PAR-CLIP	22012620
MIRT533506	hsa-miR-4700-5p	PAR-CLIP	22012620
MIRT533505	hsa-miR-8089	PAR-CLIP	22012620
MIRT533504	hsa-miR-637	PAR-CLIP	22012620
MIRT533503	hsa-miR-7155-5p	PAR-CLIP	22012620
MIRT533502	hsa-miR-4468	PAR-CLIP	22012620
MIRT533501	hsa-miR-4271	PAR-CLIP	22012620
MIRT533500	hsa-miR-4725-3p	PAR-CLIP	22012620
MIRT533499	hsa-miR-6780b-5p	PAR-CLIP	22012620
MIRT533498	hsa-miR-2110	PAR-CLIP	22012620
MIRT533497	hsa-miR-4761-3p	PAR-CLIP	22012620
MIRT533496	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT533495	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT533494	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT533493	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT533492	hsa-miR-3666	PAR-CLIP	22012620
MIRT533491	hsa-miR-4295	PAR-CLIP	22012620
MIRT533490	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT533489	hsa-miR-3614-5p	PAR-CLIP	22012620
MIRT533488	hsa-miR-3150b-3p	PAR-CLIP	22012620
MIRT533487	hsa-miR-4784	PAR-CLIP	22012620
MIRT533486	hsa-miR-4653-3p	PAR-CLIP	22012620
MIRT533485	hsa-miR-1256	PAR-CLIP	22012620
MIRT533484	hsa-miR-6881-5p	PAR-CLIP	22012620
MIRT533483	hsa-miR-4671-3p	PAR-CLIP	22012620
MIRT533482	hsa-miR-4473	PAR-CLIP	22012620
MIRT533481	hsa-miR-3915	PAR-CLIP	22012620
MIRT533480	hsa-miR-1224-5p	PAR-CLIP	22012620
MIRT533479	hsa-miR-4689	PAR-CLIP	22012620
MIRT533478	hsa-miR-6858-5p	PAR-CLIP	22012620
MIRT533477	hsa-miR-4325	PAR-CLIP	22012620
MIRT533476	hsa-miR-6737-5p	PAR-CLIP	22012620
MIRT533475	hsa-miR-6812-5p	PAR-CLIP	22012620
MIRT533474	hsa-miR-6819-5p	PAR-CLIP	22012620
MIRT533473	hsa-miR-3170	PAR-CLIP	22012620
MIRT533472	hsa-miR-6855-5p	PAR-CLIP	22012620
MIRT533471	hsa-miR-5572	PAR-CLIP	22012620
MIRT533470	hsa-miR-183-5p	PAR-CLIP	22012620
MIRT533469	hsa-miR-96-5p	PAR-CLIP	22012620
MIRT533468	hsa-miR-1271-5p	PAR-CLIP	22012620
MIRT533467	hsa-miR-182-5p	PAR-CLIP	22012620
MIRT533461	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT533466	hsa-miR-3156-5p	PAR-CLIP	22012620
MIRT533465	hsa-miR-1243	PAR-CLIP	22012620
MIRT533464	hsa-miR-2115-3p	PAR-CLIP	22012620
MIRT533463	hsa-miR-378j	PAR-CLIP	22012620
MIRT533462	hsa-miR-6839-5p	PAR-CLIP	22012620
MIRT533461	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT533460	hsa-miR-593-5p	PAR-CLIP	22012620
MIRT002076	hsa-let-7c-5p	3'LIFE	25074381
MIRT002076	hsa-let-7c-5p	3'LIFE	25074381
MIRT641833	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641831	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT652155	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT652154	hsa-miR-4679	HITS-CLIP	23824327
MIRT652153	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT652152	hsa-miR-4770	HITS-CLIP	23824327
MIRT652151	hsa-miR-6088	HITS-CLIP	23824327
MIRT652150	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT652149	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641830	hsa-miR-655-5p	HITS-CLIP	23824327
MIRT641829	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT641828	hsa-miR-6086	HITS-CLIP	23824327
MIRT652148	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT641827	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT652147	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT652146	hsa-miR-133a-3p	HITS-CLIP	23824327
MIRT652145	hsa-miR-133b	HITS-CLIP	23824327
MIRT641833	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641832	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641831	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT641830	hsa-miR-655-5p	HITS-CLIP	23824327
MIRT641829	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT641828	hsa-miR-6086	HITS-CLIP	23824327
MIRT641827	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT243480	hsa-miR-4500	PAR-CLIP	20371350
MIRT002076	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT243471	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT243472	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT243475	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT243473	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT243477	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT002077	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT243476	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT243479	hsa-miR-4458	PAR-CLIP	20371350
MIRT243474	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT355451	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT243489	hsa-miR-5680	PAR-CLIP	20371350
MIRT243482	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT243490	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT565225	hsa-miR-34c-3p	PAR-CLIP	20371350
MIRT243485	hsa-miR-4495	PAR-CLIP	20371350
MIRT565224	hsa-miR-203a-3p	PAR-CLIP	20371350
MIRT407940	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT565223	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT243488	hsa-miR-5093	PAR-CLIP	20371350
MIRT243483	hsa-miR-3935	PAR-CLIP	20371350
MIRT255609	hsa-miR-3908	PAR-CLIP	22012620
MIRT255611	hsa-miR-4759	PAR-CLIP	22012620
MIRT255607	hsa-miR-3169	PAR-CLIP	22012620
MIRT255613	hsa-miR-8083	PAR-CLIP	22012620
MIRT243478	hsa-miR-3607-3p	PAR-CLIP	22012620
MIRT533513	hsa-miR-6792-5p	PAR-CLIP	22012620
MIRT255606	hsa-miR-3117-3p	PAR-CLIP	22012620
MIRT533512	hsa-miR-452-3p	PAR-CLIP	22012620
MIRT533511	hsa-miR-3686	PAR-CLIP	22012620
MIRT255610	hsa-miR-4503	PAR-CLIP	22012620
MIRT533510	hsa-miR-1276	PAR-CLIP	22012620
MIRT533509	hsa-miR-2278	PAR-CLIP	22012620
MIRT533508	hsa-miR-1298-3p	PAR-CLIP	22012620
MIRT533507	hsa-miR-4667-5p	PAR-CLIP	22012620
MIRT533506	hsa-miR-4700-5p	PAR-CLIP	22012620
MIRT533505	hsa-miR-8089	PAR-CLIP	22012620
MIRT533504	hsa-miR-637	PAR-CLIP	22012620
MIRT533503	hsa-miR-7155-5p	PAR-CLIP	22012620
MIRT533502	hsa-miR-4468	PAR-CLIP	22012620
MIRT533501	hsa-miR-4271	PAR-CLIP	22012620
MIRT533500	hsa-miR-4725-3p	PAR-CLIP	22012620
MIRT533499	hsa-miR-6780b-5p	PAR-CLIP	22012620
MIRT533498	hsa-miR-2110	PAR-CLIP	22012620
MIRT533497	hsa-miR-4761-3p	PAR-CLIP	22012620
MIRT533496	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT533495	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT533494	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT533493	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT533492	hsa-miR-3666	PAR-CLIP	22012620
MIRT533491	hsa-miR-4295	PAR-CLIP	22012620
MIRT533490	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT533489	hsa-miR-3614-5p	PAR-CLIP	22012620
MIRT533488	hsa-miR-3150b-3p	PAR-CLIP	22012620
MIRT533487	hsa-miR-4784	PAR-CLIP	22012620
MIRT533486	hsa-miR-4653-3p	PAR-CLIP	22012620
MIRT533485	hsa-miR-1256	PAR-CLIP	22012620
MIRT533484	hsa-miR-6881-5p	PAR-CLIP	22012620
MIRT533483	hsa-miR-4671-3p	PAR-CLIP	22012620
MIRT533482	hsa-miR-4473	PAR-CLIP	22012620
MIRT533481	hsa-miR-3915	PAR-CLIP	22012620
MIRT533480	hsa-miR-1224-5p	PAR-CLIP	22012620
MIRT533479	hsa-miR-4689	PAR-CLIP	22012620
MIRT533478	hsa-miR-6858-5p	PAR-CLIP	22012620
MIRT533477	hsa-miR-4325	PAR-CLIP	22012620
MIRT533476	hsa-miR-6737-5p	PAR-CLIP	22012620
MIRT533475	hsa-miR-6812-5p	PAR-CLIP	22012620
MIRT533474	hsa-miR-6819-5p	PAR-CLIP	22012620
MIRT533473	hsa-miR-3170	PAR-CLIP	22012620
MIRT533472	hsa-miR-6855-5p	PAR-CLIP	22012620
MIRT533471	hsa-miR-5572	PAR-CLIP	22012620
MIRT533470	hsa-miR-183-5p	PAR-CLIP	22012620
MIRT533469	hsa-miR-96-5p	PAR-CLIP	22012620
MIRT533468	hsa-miR-1271-5p	PAR-CLIP	22012620
MIRT533467	hsa-miR-182-5p	PAR-CLIP	22012620
MIRT533461	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT533466	hsa-miR-3156-5p	PAR-CLIP	22012620
MIRT533465	hsa-miR-1243	PAR-CLIP	22012620
MIRT533464	hsa-miR-2115-3p	PAR-CLIP	22012620
MIRT533463	hsa-miR-378j	PAR-CLIP	22012620
MIRT533462	hsa-miR-6839-5p	PAR-CLIP	22012620
MIRT533461	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT533460	hsa-miR-593-5p	PAR-CLIP	22012620
MIRT1456025	hsa-miR-125a-5p	CLIP-seq
MIRT1456026	hsa-miR-125b	CLIP-seq
MIRT1456027	hsa-miR-3672	CLIP-seq
MIRT1456028	hsa-miR-4319	CLIP-seq
MIRT1456029	hsa-miR-4324	CLIP-seq
MIRT1456030	hsa-miR-4329	CLIP-seq
MIRT1456031	hsa-miR-4446-5p	CLIP-seq
MIRT1456032	hsa-miR-4732-3p	CLIP-seq
MIRT1456033	hsa-miR-4755-5p	CLIP-seq
MIRT1456034	hsa-miR-513a-3p	CLIP-seq
MIRT1456035	hsa-miR-670	CLIP-seq
MIRT1922443	hsa-miR-1244	CLIP-seq
MIRT1922444	hsa-miR-129-5p	CLIP-seq
MIRT1922445	hsa-miR-139-5p	CLIP-seq
MIRT1922446	hsa-miR-1825	CLIP-seq
MIRT1922447	hsa-miR-199a-5p	CLIP-seq
MIRT1922448	hsa-miR-199b-5p	CLIP-seq
MIRT1922449	hsa-miR-2113	CLIP-seq
MIRT1922450	hsa-miR-24	CLIP-seq
MIRT1922451	hsa-miR-3189-3p	CLIP-seq
MIRT1922452	hsa-miR-4284	CLIP-seq
MIRT1922453	hsa-miR-502-5p	CLIP-seq
MIRT1922454	hsa-miR-599	CLIP-seq
MIRT2136706	hsa-miR-298	CLIP-seq
MIRT2357520	hsa-miR-4755-3p	CLIP-seq

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IEA
GO:0000082	Process	G1/S transition of mitotic cell cycle	ISS
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0000932	Component	P-body	IDA	23125361
GO:0000932	Component	P-body	IEA
GO:0000932	Component	P-body	ISS
GO:0001843	Process	Neural tube closure	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0005515	Function	Protein binding	IPI	23125361
GO:0005737	Component	Cytoplasm	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	IEA
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	ISS
GO:0010608	Process	Post-transcriptional regulation of gene expression	IMP	28431233
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0017148	Process	Negative regulation of translation	IDA	23125361
GO:0017148	Process	Negative regulation of translation	IEA
GO:0021915	Process	Neural tube development	IEA
GO:0021915	Process	Neural tube development	ISS
GO:0030371	Function	Translation repressor activity	IDA	23125361
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0035196	Process	MiRNA processing	IMP	28431233
GO:0035198	Function	MiRNA binding	IDA	28431233
GO:0035198	Function	MiRNA binding	IEA
GO:0035198	Function	MiRNA binding	ISS
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IEA
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	ISS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051246	Process	Regulation of protein metabolic process	IEA
GO:0051865	Process	Protein autoubiquitination	IEA
GO:0051865	Process	Protein autoubiquitination	ISS
GO:0060964	Process	Regulation of miRNA-mediated gene silencing	IEA
GO:0061158	Process	3'-UTR-mediated mRNA destabilization	IDA	23125361
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0072089	Process	Stem cell proliferation	IEA
GO:0072089	Process	Stem cell proliferation	ISS
GO:2000177	Process	Regulation of neural precursor cell proliferation	IEA
GO:2000177	Process	Regulation of neural precursor cell proliferation	ISS
GO:2000637	Process	Positive regulation of miRNA-mediated gene silencing	IEA

MIM	HGNC	e!Ensembl
618570	32669	ENSG00000206557

Q2Q1W2

Protein name

E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)

Protein function

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repress

PDB

7QRX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00643	zf-B_box	273 → 314	B-box zinc finger	Domain
PF00630	Filamin	482 → 577	Filamin/ABP280 repeat	Domain
PF01436	NHL	606 → 633	NHL repeat	Repeat
PF01436	NHL	653 → 680	NHL repeat	Repeat
PF01436	NHL	700 → 727	NHL repeat	Repeat
PF01436	NHL	747 → 774	NHL repeat	Repeat
PF01436	NHL	794 → 821	NHL repeat	Repeat
PF01436	NHL	841 → 868	NHL repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in testis. {ECO:0000269|PubMed:15722555}.

Sequence

MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLP
CLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLL
DAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSA
PGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIER
GPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRE
CTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVV
QSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQ
VLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSS
GAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEV
SDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEG
DSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVA
CDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTR
NHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQS
ARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQ
MDRPSGIAITPDGMIVVVDFGNNRILVF

Sequence length

868

Interactions

View interactions

	KEGG		Reactome
	MicroRNAs in cancer		Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Congenital hydrocephalus	Likely pathogenic	rs1575362239	RCV000845205	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hydrocephalus, congenital communicating, 1	Pathogenic	rs1575362216, rs1575362492	RCV000856614 RCV000856615	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Non-obstructive azoospermia	Likely pathogenic	rs1696081301	RCV001290746	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
TRIM71-related disorder	Likely pathogenic	rs2471021164	RCV003899304	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL COMMUNICATING HYDROCEPHALUS	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cryptozoospermia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYDROCEPHALUS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYDROCEPHALUS, CONGENITAL, 4	—	Disgenet, HPO Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREECLAMPSIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR AZOOSPERMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	31732746	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	31732746, 36244648	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Associate	29983323, 32816599, 40603987	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leukemia Myeloid Acute	Associate	25996682	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liposarcoma Myxoid	Associate	25115389	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	25996682	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	31732746	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuraminidase 1 deficiency	Associate	25115389	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	33685397	★★★★★ ★☆☆☆☆ Found in Text Mining only

TRIM71 (tripartite motif containing 71)