PROKR2 (prokineticin receptor 2)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
128674
Gene name Gene Name - the full gene name approved by the HGNC.
Prokineticin receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PROKR2
Synonyms (NCBI Gene) Gene synonyms aliases
GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p12.3
Summary Summary of gene provided in NCBI Entrez Gene.
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
SNP ID Visualize variation Clinical significance Consequence
rs74315416 A>C Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign Coding sequence variant, missense variant
rs74315417 T>C,G Pathogenic Coding sequence variant, missense variant
rs74315418 C>A,T Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign Coding sequence variant, missense variant
rs74315419 C>T Pathogenic Coding sequence variant, missense variant
rs138672528 C>T Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT019359 hsa-miR-148b-3p Microarray 17612493
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004983 Function Neuropeptide Y receptor activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
607123 15836 ENSG00000101292
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q8NFJ6
Protein name Prokineticin receptor 2 (PK-R2) (G-protein coupled receptor 73-like 1) (G-protein coupled receptor I5E) (GPR73b) (GPRg2)
Protein function Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 70 → 333 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary and brain.
Sequence
Sequence length 384
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Peptide ligand-binding receptors
G alpha (q) signalling events
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Hypogonadotropic Hypogonadism with or without Anosmia hypogonadotropic hypogonadism 3 with or without anosmia rs587777834, rs74315419, rs886037916 N/A
Hypogonadotropic Hypogonadism With Or Without Anosmia Hypogonadotropic hypogonadism 2 with or without anosmia rs587777834 N/A
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hypogonadotropic Hypogonadism hypogonadotropic hypogonadism N/A N/A ClinVar
Male infertility male infertility with azoospermia or oligozoospermia due to single gene mutation N/A N/A ClinVar
Show/Hide Text Mining Associations (49)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 25064403
Abortion Spontaneous Associate 25064403
Adrenal Gland Diseases Associate 26475302
Adrenocortical Adenoma Associate 26475302
Amenorrhea Associate 21247312
Cerebellar Ataxia and Hypogonadotropic Hypogonadism Associate 26207952, 37605180
CHARGE Syndrome Associate 24204987
Chlamydia Infections Associate 21224062
Colorectal Neoplasms Associate 26372733, 29226856
Combined Pituitary Hormone Deficiency Associate 37338295