Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
127933
Gene name Gene Name - the full gene name approved by the HGNC.
U2AF homology motif kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UHMK1
Synonyms (NCBI Gene) Gene synonyms aliases
KIS, KIST, P-CIP2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought t
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs869312863 C>T Likely-pathogenic Missense variant, coding sequence variant, 3 prime UTR variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004890 hsa-miR-124-3p Microarray 15685193
MIRT017233 hsa-miR-335-5p Microarray 18185580
MIRT019310 hsa-miR-148b-3p Microarray 17612493
MIRT021385 hsa-miR-9-5p Microarray 17612493
MIRT004890 hsa-miR-124-3p Microarray 18668037
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 12093740
GO:0005515 Function Protein binding IPI 12093740, 26420826
GO:0005524 Function ATP binding IC 12093740
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608849 19683 ENSG00000152332
Protein
UniProt ID Q8TAS1
Protein name Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1)
Protein function Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 23 304 Protein kinase domain Domain
PF00076 RRM_1 344 400 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:12093740}.
Sequence
Sequence length 419
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
19747464, 21399567, 16978587, 18414510
Unknown
Disease term Disease name Evidence References Source
Cervical Cancer Cervical Cancer Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2). GWAS, CBGDA
Takayasu Arteritis Takayasu Arteritis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 36919755
Carcinogenesis Associate 35501324
Carcinoma Pancreatic Ductal Associate 29660218
Colorectal Neoplasms Stimulate 35501324
Hypoxia Associate 38287425
Leukemia Inhibit 29307747
Melanoma Associate 34708547, 35232962
Myelodysplastic Syndromes Stimulate 29307747
Neoplasms Associate 35238908
Neoplasms Stimulate 36919755