Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1271
Gene name Gene Name - the full gene name approved by the HGNC.	Ciliary neurotrophic factor receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CNTFR
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and ge

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029854	hsa-miR-26b-5p	Microarray	19088304
MIRT438715	hsa-miR-708-5p	Luciferase reporter assay, qRT-PCR, Western blot	23970374
MIRT438715	hsa-miR-708-5p	Luciferase reporter assay, qRT-PCR, Western blot	23970374
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901531	hsa-miR-3154	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901534	hsa-miR-3660	CLIP-seq
MIRT901535	hsa-miR-3688-5p	CLIP-seq
MIRT901536	hsa-miR-4292	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT901538	hsa-miR-4475	CLIP-seq
MIRT901539	hsa-miR-4494	CLIP-seq
MIRT901540	hsa-miR-4513	CLIP-seq
MIRT901541	hsa-miR-4525	CLIP-seq
MIRT901542	hsa-miR-4526	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901544	hsa-miR-4716-3p	CLIP-seq
MIRT901545	hsa-miR-4723-5p	CLIP-seq
MIRT901546	hsa-miR-4725-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901548	hsa-miR-4731-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901550	hsa-miR-4761-3p	CLIP-seq
MIRT901551	hsa-miR-499a-5p	CLIP-seq
MIRT901552	hsa-miR-504	CLIP-seq
MIRT901553	hsa-miR-637	CLIP-seq
MIRT901554	hsa-miR-1207-5p	CLIP-seq
MIRT901555	hsa-miR-3180	CLIP-seq
MIRT901556	hsa-miR-3180-3p	CLIP-seq
MIRT901557	hsa-miR-3196	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901558	hsa-miR-4446-3p	CLIP-seq
MIRT901559	hsa-miR-4466	CLIP-seq
MIRT901560	hsa-miR-4488	CLIP-seq
MIRT901561	hsa-miR-4492	CLIP-seq
MIRT901562	hsa-miR-4498	CLIP-seq
MIRT901563	hsa-miR-4505	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901564	hsa-miR-4697-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901548	hsa-miR-4731-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901565	hsa-miR-4763-3p	CLIP-seq
MIRT901553	hsa-miR-637	CLIP-seq
MIRT901566	hsa-miR-675	CLIP-seq
MIRT901567	hsa-miR-762	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901531	hsa-miR-3154	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901534	hsa-miR-3660	CLIP-seq
MIRT901538	hsa-miR-4475	CLIP-seq
MIRT901539	hsa-miR-4494	CLIP-seq
MIRT901540	hsa-miR-4513	CLIP-seq
MIRT901542	hsa-miR-4526	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901550	hsa-miR-4761-3p	CLIP-seq
MIRT901551	hsa-miR-499a-5p	CLIP-seq
MIRT1967448	hsa-miR-1184	CLIP-seq
MIRT1967449	hsa-miR-1205	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT1967450	hsa-miR-3158-5p	CLIP-seq
MIRT1967451	hsa-miR-3909	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT2203129	hsa-miR-28-5p	CLIP-seq
MIRT2203130	hsa-miR-3139	CLIP-seq
MIRT2203131	hsa-miR-708	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001967	Process	Suckling behavior	IEA
GO:0003360	Process	Brainstem development	IEA
GO:0004896	Function	Cytokine receptor activity	IBA	21873635
GO:0004897	Function	Ciliary neurotrophic factor receptor activity	IBA	21873635
GO:0004897	Function	Ciliary neurotrophic factor receptor activity	IDA	12643274
GO:0005102	Function	Signaling receptor binding	IPI	12707266
GO:0005515	Function	Protein binding	IPI	18775332, 20584990, 26858303
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	NAS	1648265
GO:0007399	Process	Nervous system development	TAS	7585948
GO:0007548	Process	Sex differentiation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0016324	Component	Apical plasma membrane	IDA	21912637
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019898	Component	Extrinsic component of membrane	TAS	1648265
GO:0019955	Function	Cytokine binding	IBA	21873635
GO:0019955	Function	Cytokine binding	IPI	15272019
GO:0031225	Component	Anchored component of membrane	IEA
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0060538	Process	Skeletal muscle organ development	IEA
GO:0070110	Component	Ciliary neurotrophic factor receptor complex	IBA	21873635
GO:0070110	Component	Ciliary neurotrophic factor receptor complex	IDA	12643274
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IBA	21873635
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IDA	12643274
GO:0097059	Component	CNTFR-CLCF1 complex	IBA	21873635
GO:0097059	Component	CNTFR-CLCF1 complex	IDA	11285233

MIM	HGNC	e!Ensembl
118946	2170	ENSG00000122756

Protein

UniProt ID

P26992

Protein name

Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)

Protein function

Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Acts as a receptor for the neuroprotective peptide humanin as part of a

PDB

1UC6 , 8D74 , 8D7E , 8D7H , 8D7R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00041	fn3	205 → 294	Fibronectin type III domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Nervous system and skeletal muscle.

Sequence

MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN
GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT
YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS
ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL
KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT
PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL
AAAAATASSLLI

Sequence length

372

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway		IL-6-type cytokine receptor ligand interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	19503088

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	34745015
Breast Neoplasms	Associate	32190687
Crisponi syndrome	Associate	17436251
Hypothyroidism	Inhibit	33600668
Leukemia Myeloid Acute	Associate	31538427
Lymphoma Large Cell Anaplastic	Associate	17077326
Neoplasm Metastasis	Associate	35280443
Neoplasms	Associate	34745015
Stuve Wiedemann syndrome	Associate	17436252
Thyroid cancer medullary	Associate	35280443
Triple Negative Breast Neoplasms	Associate	32190687

CNTFR (ciliary neurotrophic factor receptor)