ALDH16A1 (aldehyde dehydrogenase 16 family member A1)

Gene

• Entrez ID: 126133
• Gene name: Aldehyde dehydrogenase 16 family member A1
• Gene symbol: ALDH16A1
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and z

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045250	hsa-miR-186-5p	CLASH	23622248
MIRT035869	hsa-miR-1247-5p	CLASH	23622248
MIRT776895	hsa-miR-4269	CLIP-seq
MIRT776896	hsa-miR-4514	CLIP-seq
MIRT776897	hsa-miR-4692	CLIP-seq
MIRT776898	hsa-miR-4698	CLIP-seq
MIRT776899	hsa-miR-4742-5p	CLIP-seq
MIRT776900	hsa-miR-1185	CLIP-seq
MIRT776901	hsa-miR-1225-3p	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776903	hsa-miR-1233	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776905	hsa-miR-1827	CLIP-seq
MIRT776906	hsa-miR-188-5p	CLIP-seq
MIRT776907	hsa-miR-3605-5p	CLIP-seq
MIRT776908	hsa-miR-3679-5p	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776910	hsa-miR-4323	CLIP-seq
MIRT776911	hsa-miR-4661-3p	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776913	hsa-miR-4780	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776915	hsa-miR-623	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT2170084	hsa-miR-323-5p	CLIP-seq
MIRT2170085	hsa-miR-3934	CLIP-seq
MIRT2170086	hsa-miR-485-5p	CLIP-seq
MIRT2170087	hsa-miR-654-3p	CLIP-seq
MIRT2170088	hsa-miR-876-3p	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781, 35271311
GO:0016020	Component	Membrane	HDA	19946888
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016620	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA

Other IDs

• MIM: 613358
• HGNC: 28114
• e!Ensembl: ENSG00000161618

Protein

• UniProt ID: Q8IZ83
• Protein name: Aldehyde dehydrogenase family 16 member A1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00171	Aldedh	48 → 488	Aldehyde dehydrogenase family	Family
  PF00171	Aldedh	539 → 774	Aldehyde dehydrogenase family	Family

• Sequence:

  MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ
  DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW
  TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL
  EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ
  PGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWS
  DRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA
  QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN
  GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG
  LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG
  ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE
  RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP
  LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN
  VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE
  GAGPELGLRVARTKALWLPMGD

• Sequence length: 802

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Colon adenocarcinoma	Uncertain significance	rs756830979	RCV005937520
Gastric cancer	Uncertain significance	rs766273860	RCV005928981
Ovarian serous cystadenocarcinoma	Uncertain significance	rs766273860	RCV005928982

Associations from Text Mining
Disease Name	Relationship Type	References
Glioblastoma	Associate	35116021
Gout	Associate	28642574
Neoplasms	Associate	35116021