Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1260
Gene name Gene Name - the full gene name approved by the HGNC.	Cyclic nucleotide gated channel subunit alpha 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CNGA2
Synonyms (NCBI Gene) Gene synonyms aliases	CNCA, CNCA1, CNG2, OCNC1, OCNCALPHA, OCNCa
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq28
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

Show/Hide all(77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	22291592
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	22291592
MIRT495164	hsa-miR-204-3p	PAR-CLIP	22291592
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	22291592
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	22291592
MIRT495161	hsa-miR-619-5p	PAR-CLIP	22291592
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	22291592
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	22291592
MIRT495158	hsa-miR-638	PAR-CLIP	22291592
MIRT495156	hsa-miR-4314	PAR-CLIP	22291592
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	22291592
MIRT495155	hsa-miR-769-3p	PAR-CLIP	22291592
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	23708386
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	23708386
MIRT495164	hsa-miR-204-3p	PAR-CLIP	23708386
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	23708386
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	23708386
MIRT495161	hsa-miR-619-5p	PAR-CLIP	23708386
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	23708386
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	23708386
MIRT495158	hsa-miR-638	PAR-CLIP	23708386
MIRT495156	hsa-miR-4314	PAR-CLIP	23708386
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	23708386
MIRT495155	hsa-miR-769-3p	PAR-CLIP	23708386
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	22291592
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	22291592
MIRT495164	hsa-miR-204-3p	PAR-CLIP	22291592
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	22291592
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	22291592
MIRT495161	hsa-miR-619-5p	PAR-CLIP	22291592
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	22291592
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	22291592
MIRT495158	hsa-miR-638	PAR-CLIP	22291592
MIRT495156	hsa-miR-4314	PAR-CLIP	22291592
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	22291592
MIRT495155	hsa-miR-769-3p	PAR-CLIP	22291592
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	23708386
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	23708386
MIRT495164	hsa-miR-204-3p	PAR-CLIP	23708386
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	23708386
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	23708386
MIRT495161	hsa-miR-619-5p	PAR-CLIP	23708386
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	23708386
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	23708386
MIRT495158	hsa-miR-638	PAR-CLIP	23708386
MIRT495156	hsa-miR-4314	PAR-CLIP	23708386
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	23708386
MIRT495155	hsa-miR-769-3p	PAR-CLIP	23708386
MIRT899513	hsa-miR-1251	CLIP-seq
MIRT899514	hsa-miR-125a-5p	CLIP-seq
MIRT899515	hsa-miR-125b	CLIP-seq
MIRT899516	hsa-miR-200b	CLIP-seq
MIRT899517	hsa-miR-200c	CLIP-seq
MIRT899518	hsa-miR-3126-5p	CLIP-seq
MIRT899519	hsa-miR-3192	CLIP-seq
MIRT899520	hsa-miR-4268	CLIP-seq
MIRT899521	hsa-miR-429	CLIP-seq
MIRT899522	hsa-miR-4319	CLIP-seq
MIRT899523	hsa-miR-4419a	CLIP-seq
MIRT899524	hsa-miR-4502	CLIP-seq
MIRT899525	hsa-miR-4510	CLIP-seq
MIRT899526	hsa-miR-4732-3p	CLIP-seq
MIRT899527	hsa-miR-670	CLIP-seq
MIRT1966822	hsa-miR-4270	CLIP-seq
MIRT1966823	hsa-miR-4441	CLIP-seq
MIRT2202596	hsa-miR-139-5p	CLIP-seq
MIRT2202597	hsa-miR-2278	CLIP-seq
MIRT2202598	hsa-miR-28-5p	CLIP-seq
MIRT2202599	hsa-miR-3139	CLIP-seq
MIRT2202600	hsa-miR-4722-5p	CLIP-seq
MIRT2202601	hsa-miR-4797-5p	CLIP-seq
MIRT2202602	hsa-miR-708	CLIP-seq
MIRT2386273	hsa-miR-3120-5p	CLIP-seq
MIRT2386274	hsa-miR-3138	CLIP-seq
MIRT2386275	hsa-miR-3925-3p	CLIP-seq
MIRT2386276	hsa-miR-766	CLIP-seq
MIRT2447291	hsa-miR-622	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0005222	Function	Intracellular cAMP-activated cation channel activity	IBA	21873635
GO:0005223	Function	Intracellular cGMP-activated cation channel activity	IBA	21873635
GO:0005516	Function	Calmodulin binding	IEA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0030552	Function	CAMP binding	IEA
GO:0030553	Function	CGMP binding	IBA	21873635
GO:0030660	Component	Golgi-associated vesicle membrane	TAS
GO:0050896	Process	Response to stimulus	IEA
GO:0060170	Component	Ciliary membrane	TAS
GO:0098655	Process	Cation transmembrane transport	IEA

MIM	HGNC	e!Ensembl
300338	2149	ENSG00000183862

Protein

UniProt ID

Q16280

Protein name

Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1)

Protein function

Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00520	Ion_trans	140 → 383	Ion transport protein	Family
PF00027	cNMP_binding	472 → 563	Cyclic nucleotide-binding domain	Domain
PF16526	CLZ	570 → 639	C-terminal leucine zipper domain of cyclic nucleotide-gated channels	Coiled-coil

Sequence

MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE
DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY
VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI
HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI
GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY
ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK
LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA
ADEP

Sequence length

664

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Olfactory transduction		VxPx cargo-targeting to cilium

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Isolated Congenital Anosmia	isolated congenital anosmia			GenCC

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Congenital anosmia	Associate	28572688, 38148624
Kallmann Syndrome	Associate	28572688

CNGA2 (cyclic nucleotide gated channel subunit alpha 2)