Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1260
Gene name	Cyclic nucleotide gated channel subunit alpha 2
Gene symbol	CNGA2
Synonyms (NCBI Gene)	CNCACNCA1CNG2OCNC1OCNCALPHAOCNCa
Chromosome	X
Chromosome location	Xq28
Summary	The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	22291592
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	22291592
MIRT495164	hsa-miR-204-3p	PAR-CLIP	22291592
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	22291592
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	22291592
MIRT495161	hsa-miR-619-5p	PAR-CLIP	22291592
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	22291592
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	22291592
MIRT495158	hsa-miR-638	PAR-CLIP	22291592
MIRT495156	hsa-miR-4314	PAR-CLIP	22291592
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	22291592
MIRT495155	hsa-miR-769-3p	PAR-CLIP	22291592
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	23708386
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	23708386
MIRT495164	hsa-miR-204-3p	PAR-CLIP	23708386
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	23708386
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	23708386
MIRT495161	hsa-miR-619-5p	PAR-CLIP	23708386
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	23708386
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	23708386
MIRT495158	hsa-miR-638	PAR-CLIP	23708386
MIRT495156	hsa-miR-4314	PAR-CLIP	23708386
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	23708386
MIRT495155	hsa-miR-769-3p	PAR-CLIP	23708386
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	22291592
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	22291592
MIRT495164	hsa-miR-204-3p	PAR-CLIP	22291592
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	22291592
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	22291592
MIRT495161	hsa-miR-619-5p	PAR-CLIP	22291592
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	22291592
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	22291592
MIRT495158	hsa-miR-638	PAR-CLIP	22291592
MIRT495156	hsa-miR-4314	PAR-CLIP	22291592
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	22291592
MIRT495155	hsa-miR-769-3p	PAR-CLIP	22291592
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	23708386
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	23708386
MIRT495164	hsa-miR-204-3p	PAR-CLIP	23708386
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	23708386
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	23708386
MIRT495161	hsa-miR-619-5p	PAR-CLIP	23708386
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	23708386
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	23708386
MIRT495158	hsa-miR-638	PAR-CLIP	23708386
MIRT495156	hsa-miR-4314	PAR-CLIP	23708386
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	23708386
MIRT495155	hsa-miR-769-3p	PAR-CLIP	23708386
MIRT899513	hsa-miR-1251	CLIP-seq
MIRT899514	hsa-miR-125a-5p	CLIP-seq
MIRT899515	hsa-miR-125b	CLIP-seq
MIRT899516	hsa-miR-200b	CLIP-seq
MIRT899517	hsa-miR-200c	CLIP-seq
MIRT899518	hsa-miR-3126-5p	CLIP-seq
MIRT899519	hsa-miR-3192	CLIP-seq
MIRT899520	hsa-miR-4268	CLIP-seq
MIRT899521	hsa-miR-429	CLIP-seq
MIRT899522	hsa-miR-4319	CLIP-seq
MIRT899523	hsa-miR-4419a	CLIP-seq
MIRT899524	hsa-miR-4502	CLIP-seq
MIRT899525	hsa-miR-4510	CLIP-seq
MIRT899526	hsa-miR-4732-3p	CLIP-seq
MIRT899527	hsa-miR-670	CLIP-seq
MIRT1966822	hsa-miR-4270	CLIP-seq
MIRT1966823	hsa-miR-4441	CLIP-seq
MIRT2202596	hsa-miR-139-5p	CLIP-seq
MIRT2202597	hsa-miR-2278	CLIP-seq
MIRT2202598	hsa-miR-28-5p	CLIP-seq
MIRT2202599	hsa-miR-3139	CLIP-seq
MIRT2202600	hsa-miR-4722-5p	CLIP-seq
MIRT2202601	hsa-miR-4797-5p	CLIP-seq
MIRT2202602	hsa-miR-708	CLIP-seq
MIRT2386273	hsa-miR-3120-5p	CLIP-seq
MIRT2386274	hsa-miR-3138	CLIP-seq
MIRT2386275	hsa-miR-3925-3p	CLIP-seq
MIRT2386276	hsa-miR-766	CLIP-seq
MIRT2447291	hsa-miR-622	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005221	Function	Intracellularly cyclic nucleotide-activated monoatomic cation channel activity	IEA
GO:0005222	Function	Intracellularly cAMP-activated cation channel activity	IBA
GO:0005223	Function	Intracellularly cGMP-activated cation channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	ISS
GO:0006814	Process	Sodium ion transport	ISS
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	ISS
GO:0007606	Process	Sensory perception of chemical stimulus	IBA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0016020	Component	Membrane	IEA
GO:0017071	Component	Intracellular cyclic nucleotide activated cation channel complex	IBA
GO:0030552	Function	CAMP binding	IEA
GO:0030553	Function	CGMP binding	IBA
GO:0030553	Function	CGMP binding	IEA
GO:0030660	Component	Golgi-associated vesicle membrane	TAS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0042995	Component	Cell projection	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0060170	Component	Ciliary membrane	IEA
GO:0060170	Component	Ciliary membrane	ISS
GO:0060170	Component	Ciliary membrane	TAS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098655	Process	Monoatomic cation transmembrane transport	IBA
GO:0098804	Component	Non-motile cilium membrane	IEA
GO:0098804	Component	Non-motile cilium membrane	ISS

MIM	HGNC	e!Ensembl
300338	2149	ENSG00000183862

Q16280

Protein name

Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1)

Protein function

Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00520	Ion_trans	140 → 383	Ion transport protein	Family
PF00027	cNMP_binding	472 → 563	Cyclic nucleotide-binding domain	Domain
PF16526	CLZ	570 → 639	C-terminal leucine zipper domain of cyclic nucleotide-gated channels	Coiled-coil

Sequence

MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE
DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY
VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI
HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI
GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY
ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK
LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA
ADEP

Sequence length

664

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Olfactory transduction		VxPx cargo-targeting to cilium

CNGA2 (cyclic nucleotide gated channel subunit alpha 2)