MSI2 (musashi RNA binding protein 2)

Gene

• Entrez ID: 124540
• Gene name: Musashi RNA binding protein 2
• Gene symbol: MSI2
• Synonyms (NCBI Gene): MSI2H
• Chromosome: 17
• Chromosome location: 17q22
• Summary: This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001533	hsa-miR-155-5p	pSILAC	18668040
MIRT001533	hsa-miR-155-5p	Western blot	20584899
MIRT042254	hsa-miR-484	CLASH	23622248
MIRT039469	hsa-miR-652-3p	CLASH	23622248
MIRT493077	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT450382	hsa-miR-3163	HITS-CLIP	21572407
MIRT547367	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT547366	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT547362	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT522418	hsa-miR-3924	HITS-CLIP	21572407
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT450382	hsa-miR-3163	PAR-CLIP	21572407
MIRT522418	hsa-miR-3924	PAR-CLIP	21572407
MIRT547380	hsa-miR-98-5p	PAR-CLIP	21572407
MIRT547379	hsa-miR-4458	PAR-CLIP	21572407
MIRT547378	hsa-let-7a-5p	PAR-CLIP	21572407
MIRT547377	hsa-let-7i-5p	PAR-CLIP	21572407
MIRT547376	hsa-let-7g-5p	PAR-CLIP	21572407
MIRT547375	hsa-let-7f-5p	PAR-CLIP	21572407
MIRT547374	hsa-miR-4500	PAR-CLIP	21572407
MIRT547373	hsa-let-7e-5p	PAR-CLIP	21572407
MIRT547372	hsa-let-7d-5p	PAR-CLIP	21572407
MIRT547371	hsa-let-7b-5p	PAR-CLIP	21572407
MIRT547370	hsa-let-7c-5p	PAR-CLIP	21572407
MIRT547369	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT547368	hsa-miR-4678	PAR-CLIP	21572407
MIRT547367	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT547366	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT547365	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT547364	hsa-miR-7162-3p	PAR-CLIP	21572407
MIRT547363	hsa-miR-202-3p	PAR-CLIP	21572407
MIRT547362	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT450382	hsa-miR-3163	PAR-CLIP	21572407
MIRT522418	hsa-miR-3924	PAR-CLIP	21572407
MIRT535846	hsa-miR-28-5p	PAR-CLIP	22012620
MIRT535845	hsa-miR-3139	PAR-CLIP	22012620
MIRT535844	hsa-miR-708-5p	PAR-CLIP	22012620
MIRT535843	hsa-miR-610	PAR-CLIP	22012620
MIRT535842	hsa-miR-1301-5p	PAR-CLIP	22012620
MIRT535841	hsa-miR-6502-5p	PAR-CLIP	22012620
MIRT535840	hsa-miR-4633-3p	PAR-CLIP	22012620
MIRT535839	hsa-miR-6500-5p	PAR-CLIP	22012620
MIRT535838	hsa-miR-676-3p	PAR-CLIP	22012620
MIRT535837	hsa-miR-2355-3p	PAR-CLIP	22012620
MIRT493078	hsa-miR-338-5p	PAR-CLIP	22012620
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	22012620
MIRT493076	hsa-miR-8076	PAR-CLIP	22012620
MIRT493075	hsa-miR-3688-3p	PAR-CLIP	22012620
MIRT522420	hsa-miR-4798-3p	PAR-CLIP	23446348
MIRT522419	hsa-miR-3680-5p	PAR-CLIP	23446348
MIRT522418	hsa-miR-3924	PAR-CLIP	23446348
MIRT493078	hsa-miR-338-5p	PAR-CLIP	23592263
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	23592263
MIRT493076	hsa-miR-8076	PAR-CLIP	23592263
MIRT493075	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT450381	hsa-miR-4282	PAR-CLIP	22100165
MIRT450382	hsa-miR-3163	PAR-CLIP	22100165
MIRT450380	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT448668	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT448667	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448668	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT448667	hsa-miR-1273e	PAR-CLIP	22100165
MIRT535842	hsa-miR-1301-5p	PAR-CLIP	26701625
MIRT535846	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT535845	hsa-miR-3139	PAR-CLIP	26701625
MIRT493078	hsa-miR-338-5p	PAR-CLIP	26701625
MIRT493078	hsa-miR-338-5p	PAR-CLIP	26701625
MIRT493075	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT493075	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT535840	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	26701625
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	26701625
MIRT535843	hsa-miR-610	PAR-CLIP	26701625
MIRT535839	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT535841	hsa-miR-6502-5p	PAR-CLIP	26701625
MIRT535844	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT493076	hsa-miR-8076	PAR-CLIP	26701625
MIRT493076	hsa-miR-8076	PAR-CLIP	26701625
MIRT493078	hsa-miR-338-5p	PAR-CLIP	27292025
MIRT493075	hsa-miR-3688-3p	PAR-CLIP	27292025
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	27292025
MIRT493076	hsa-miR-8076	PAR-CLIP	27292025
MIRT734805	hsa-miR-301a-3p	Western blotting, Immunoprecipitaion (IP), RNA-seq, qRT-PCR	33553241
MIRT738765	hsa-miR-1251	HITS-CLIP	33718276
MIRT738767	hsa-miR-4723-3p	HITS-CLIP	33718276
MIRT738772	hsa-miR-3199	HITS-CLIP	33718276
MIRT493077	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT450382	hsa-miR-3163	HITS-CLIP	21572407
MIRT547367	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT547366	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT547362	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT522418	hsa-miR-3924	HITS-CLIP	21572407
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT450382	hsa-miR-3163	PAR-CLIP	21572407
MIRT522418	hsa-miR-3924	PAR-CLIP	21572407
MIRT547380	hsa-miR-98-5p	PAR-CLIP	21572407
MIRT547379	hsa-miR-4458	PAR-CLIP	21572407
MIRT547378	hsa-let-7a-5p	PAR-CLIP	21572407
MIRT547377	hsa-let-7i-5p	PAR-CLIP	21572407
MIRT547376	hsa-let-7g-5p	PAR-CLIP	21572407
MIRT547375	hsa-let-7f-5p	PAR-CLIP	21572407
MIRT547374	hsa-miR-4500	PAR-CLIP	21572407
MIRT547373	hsa-let-7e-5p	PAR-CLIP	21572407
MIRT547372	hsa-let-7d-5p	PAR-CLIP	21572407
MIRT547371	hsa-let-7b-5p	PAR-CLIP	21572407
MIRT547370	hsa-let-7c-5p	PAR-CLIP	21572407
MIRT547369	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT547368	hsa-miR-4678	PAR-CLIP	21572407
MIRT547367	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT547366	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT547365	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT547364	hsa-miR-7162-3p	PAR-CLIP	21572407
MIRT547363	hsa-miR-202-3p	PAR-CLIP	21572407
MIRT547362	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT450382	hsa-miR-3163	PAR-CLIP	21572407
MIRT522418	hsa-miR-3924	PAR-CLIP	21572407
MIRT535846	hsa-miR-28-5p	PAR-CLIP	22012620
MIRT535845	hsa-miR-3139	PAR-CLIP	22012620
MIRT535844	hsa-miR-708-5p	PAR-CLIP	22012620
MIRT535843	hsa-miR-610	PAR-CLIP	22012620
MIRT535842	hsa-miR-1301-5p	PAR-CLIP	22012620
MIRT535841	hsa-miR-6502-5p	PAR-CLIP	22012620
MIRT535840	hsa-miR-4633-3p	PAR-CLIP	22012620
MIRT535839	hsa-miR-6500-5p	PAR-CLIP	22012620
MIRT535838	hsa-miR-676-3p	PAR-CLIP	22012620
MIRT535837	hsa-miR-2355-3p	PAR-CLIP	22012620
MIRT493078	hsa-miR-338-5p	PAR-CLIP	22012620
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	22012620
MIRT493076	hsa-miR-8076	PAR-CLIP	22012620
MIRT493075	hsa-miR-3688-3p	PAR-CLIP	22012620
MIRT522420	hsa-miR-4798-3p	PAR-CLIP	23446348
MIRT522419	hsa-miR-3680-5p	PAR-CLIP	23446348
MIRT522418	hsa-miR-3924	PAR-CLIP	23446348
MIRT493078	hsa-miR-338-5p	PAR-CLIP	23592263
MIRT493077	hsa-miR-5580-3p	PAR-CLIP	23592263
MIRT493076	hsa-miR-8076	PAR-CLIP	23592263
MIRT493075	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT450381	hsa-miR-4282	PAR-CLIP	22100165
MIRT450382	hsa-miR-3163	PAR-CLIP	22100165
MIRT450380	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT448668	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT448667	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448668	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT448667	hsa-miR-1273e	PAR-CLIP	22100165
MIRT1161346	hsa-miR-1224-5p	CLIP-seq
MIRT1161347	hsa-miR-1243	CLIP-seq
MIRT1161348	hsa-miR-1254	CLIP-seq
MIRT1161349	hsa-miR-134	CLIP-seq
MIRT1161350	hsa-miR-138	CLIP-seq
MIRT1161351	hsa-miR-224	CLIP-seq
MIRT1161352	hsa-miR-2467-5p	CLIP-seq
MIRT1161353	hsa-miR-3116	CLIP-seq
MIRT1161354	hsa-miR-3118	CLIP-seq
MIRT1161355	hsa-miR-3150a-3p	CLIP-seq
MIRT1161356	hsa-miR-3164	CLIP-seq
MIRT1161357	hsa-miR-3175	CLIP-seq
MIRT1161358	hsa-miR-3188	CLIP-seq
MIRT1161359	hsa-miR-326	CLIP-seq
MIRT1161360	hsa-miR-330-5p	CLIP-seq
MIRT1161361	hsa-miR-34b	CLIP-seq
MIRT1161362	hsa-miR-34c-3p	CLIP-seq
MIRT1161363	hsa-miR-3654	CLIP-seq
MIRT1161364	hsa-miR-3690	CLIP-seq
MIRT1161365	hsa-miR-378	CLIP-seq
MIRT1161366	hsa-miR-378b	CLIP-seq
MIRT1161367	hsa-miR-378c	CLIP-seq
MIRT1161368	hsa-miR-378d	CLIP-seq
MIRT1161369	hsa-miR-378e	CLIP-seq
MIRT1161370	hsa-miR-378f	CLIP-seq
MIRT1161371	hsa-miR-378h	CLIP-seq
MIRT1161372	hsa-miR-378i	CLIP-seq
MIRT1161373	hsa-miR-3913-3p	CLIP-seq
MIRT1161374	hsa-miR-422a	CLIP-seq
MIRT1161375	hsa-miR-431	CLIP-seq
MIRT1161376	hsa-miR-4311	CLIP-seq
MIRT1161377	hsa-miR-4316	CLIP-seq
MIRT1161378	hsa-miR-4425	CLIP-seq
MIRT1161379	hsa-miR-4447	CLIP-seq
MIRT1161380	hsa-miR-4454	CLIP-seq
MIRT1161381	hsa-miR-4456	CLIP-seq
MIRT1161382	hsa-miR-4472	CLIP-seq
MIRT1161383	hsa-miR-4501	CLIP-seq
MIRT1161384	hsa-miR-450b-3p	CLIP-seq
MIRT1161385	hsa-miR-4638-3p	CLIP-seq
MIRT1161386	hsa-miR-4649-3p	CLIP-seq
MIRT1161387	hsa-miR-4671-5p	CLIP-seq
MIRT1161388	hsa-miR-4698	CLIP-seq
MIRT1161389	hsa-miR-4751	CLIP-seq
MIRT1161390	hsa-miR-485-5p	CLIP-seq
MIRT1161391	hsa-miR-499-3p	CLIP-seq
MIRT1161392	hsa-miR-499a-3p	CLIP-seq
MIRT1161393	hsa-miR-541	CLIP-seq
MIRT1161394	hsa-miR-615-5p	CLIP-seq
MIRT1161395	hsa-miR-654-5p	CLIP-seq
MIRT1161396	hsa-miR-661	CLIP-seq
MIRT1161397	hsa-miR-769-3p	CLIP-seq
MIRT1161398	hsa-miR-939	CLIP-seq
MIRT1161399	hsa-miR-1229	CLIP-seq
MIRT1161400	hsa-miR-1255a	CLIP-seq
MIRT1161401	hsa-miR-1255b	CLIP-seq
MIRT1161402	hsa-miR-3065-3p	CLIP-seq
MIRT1161403	hsa-miR-3148	CLIP-seq
MIRT1161404	hsa-miR-342-3p	CLIP-seq
MIRT1161405	hsa-miR-4270	CLIP-seq
MIRT1161406	hsa-miR-4434	CLIP-seq
MIRT1161407	hsa-miR-4441	CLIP-seq
MIRT1161408	hsa-miR-4516	CLIP-seq
MIRT1161409	hsa-miR-4668-5p	CLIP-seq
MIRT1161410	hsa-miR-4719	CLIP-seq
MIRT1161411	hsa-miR-5095	CLIP-seq
MIRT1161412	hsa-miR-548ad	CLIP-seq
MIRT1161413	hsa-miR-598	CLIP-seq
MIRT1161414	hsa-miR-600	CLIP-seq
MIRT1161415	hsa-miR-619	CLIP-seq
MIRT1161416	hsa-miR-634	CLIP-seq
MIRT1161417	hsa-miR-885-3p	CLIP-seq
MIRT1161346	hsa-miR-1224-5p	CLIP-seq
MIRT2046302	hsa-miR-1272	CLIP-seq
MIRT2046303	hsa-miR-1273f	CLIP-seq
MIRT1161350	hsa-miR-138	CLIP-seq
MIRT2046304	hsa-miR-143	CLIP-seq
MIRT1161352	hsa-miR-2467-5p	CLIP-seq
MIRT2046305	hsa-miR-3120-3p	CLIP-seq
MIRT1161355	hsa-miR-3150a-3p	CLIP-seq
MIRT1161357	hsa-miR-3175	CLIP-seq
MIRT1161358	hsa-miR-3188	CLIP-seq
MIRT2046306	hsa-miR-320a	CLIP-seq
MIRT2046307	hsa-miR-320b	CLIP-seq
MIRT2046308	hsa-miR-320c	CLIP-seq
MIRT2046309	hsa-miR-320d	CLIP-seq
MIRT1161359	hsa-miR-326	CLIP-seq
MIRT1161360	hsa-miR-330-5p	CLIP-seq
MIRT1161373	hsa-miR-3913-3p	CLIP-seq
MIRT1161377	hsa-miR-4316	CLIP-seq
MIRT1161378	hsa-miR-4425	CLIP-seq
MIRT2046310	hsa-miR-4429	CLIP-seq
MIRT1161379	hsa-miR-4447	CLIP-seq
MIRT1161380	hsa-miR-4454	CLIP-seq
MIRT1161381	hsa-miR-4456	CLIP-seq
MIRT1161382	hsa-miR-4472	CLIP-seq
MIRT1161384	hsa-miR-450b-3p	CLIP-seq
MIRT1161386	hsa-miR-4649-3p	CLIP-seq
MIRT1161387	hsa-miR-4671-5p	CLIP-seq
MIRT2046311	hsa-miR-4708-5p	CLIP-seq
MIRT1161389	hsa-miR-4751	CLIP-seq
MIRT2046312	hsa-miR-4770	CLIP-seq
MIRT1161390	hsa-miR-485-5p	CLIP-seq
MIRT1161391	hsa-miR-499-3p	CLIP-seq
MIRT1161392	hsa-miR-499a-3p	CLIP-seq
MIRT2046313	hsa-miR-511	CLIP-seq
MIRT1161393	hsa-miR-541	CLIP-seq
MIRT1161394	hsa-miR-615-5p	CLIP-seq
MIRT1161395	hsa-miR-654-5p	CLIP-seq
MIRT2046314	hsa-miR-656	CLIP-seq
MIRT1161397	hsa-miR-769-3p	CLIP-seq
MIRT2046315	hsa-miR-922	CLIP-seq
MIRT1161398	hsa-miR-939	CLIP-seq
MIRT1161346	hsa-miR-1224-5p	CLIP-seq
MIRT1161347	hsa-miR-1243	CLIP-seq
MIRT2046302	hsa-miR-1272	CLIP-seq
MIRT2046303	hsa-miR-1273f	CLIP-seq
MIRT1161350	hsa-miR-138	CLIP-seq
MIRT2046304	hsa-miR-143	CLIP-seq
MIRT1161351	hsa-miR-224	CLIP-seq
MIRT1161352	hsa-miR-2467-5p	CLIP-seq
MIRT2046305	hsa-miR-3120-3p	CLIP-seq
MIRT1161358	hsa-miR-3188	CLIP-seq
MIRT2046306	hsa-miR-320a	CLIP-seq
MIRT2046307	hsa-miR-320b	CLIP-seq
MIRT2046308	hsa-miR-320c	CLIP-seq
MIRT2046309	hsa-miR-320d	CLIP-seq
MIRT1161361	hsa-miR-34b	CLIP-seq
MIRT1161362	hsa-miR-34c-3p	CLIP-seq
MIRT1161363	hsa-miR-3654	CLIP-seq
MIRT1161365	hsa-miR-378	CLIP-seq
MIRT1161366	hsa-miR-378b	CLIP-seq
MIRT1161367	hsa-miR-378c	CLIP-seq
MIRT1161368	hsa-miR-378d	CLIP-seq
MIRT1161369	hsa-miR-378e	CLIP-seq
MIRT1161370	hsa-miR-378f	CLIP-seq
MIRT1161371	hsa-miR-378h	CLIP-seq
MIRT1161372	hsa-miR-378i	CLIP-seq
MIRT1161373	hsa-miR-3913-3p	CLIP-seq
MIRT1161374	hsa-miR-422a	CLIP-seq
MIRT1161377	hsa-miR-4316	CLIP-seq
MIRT2046310	hsa-miR-4429	CLIP-seq
MIRT1161379	hsa-miR-4447	CLIP-seq
MIRT1161381	hsa-miR-4456	CLIP-seq
MIRT1161382	hsa-miR-4472	CLIP-seq
MIRT1161386	hsa-miR-4649-3p	CLIP-seq
MIRT1161388	hsa-miR-4698	CLIP-seq
MIRT2046311	hsa-miR-4708-5p	CLIP-seq
MIRT1161389	hsa-miR-4751	CLIP-seq
MIRT2046312	hsa-miR-4770	CLIP-seq
MIRT1161390	hsa-miR-485-5p	CLIP-seq
MIRT1161391	hsa-miR-499-3p	CLIP-seq
MIRT1161392	hsa-miR-499a-3p	CLIP-seq
MIRT2046313	hsa-miR-511	CLIP-seq
MIRT1161393	hsa-miR-541	CLIP-seq
MIRT1161394	hsa-miR-615-5p	CLIP-seq
MIRT1161395	hsa-miR-654-5p	CLIP-seq
MIRT2046314	hsa-miR-656	CLIP-seq
MIRT2046315	hsa-miR-922	CLIP-seq
MIRT2046302	hsa-miR-1272	CLIP-seq
MIRT2046303	hsa-miR-1273f	CLIP-seq
MIRT2046304	hsa-miR-143	CLIP-seq
MIRT2046311	hsa-miR-4708-5p	CLIP-seq
MIRT2046312	hsa-miR-4770	CLIP-seq
MIRT2046315	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 27941885, 30367664, 32296183, 33961781, 35063084, 35271311, 37207277
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006417	Process	Regulation of translation	IBA
GO:0007417	Process	Central nervous system development	IBA
GO:0008266	Function	Poly(U) RNA binding	IEA
GO:0042802	Function	Identical protein binding	IPI	30367664
GO:0048864	Process	Stem cell development	IEA

Other IDs

• MIM: 607897
• HGNC: 18585
• e!Ensembl: ENSG00000153944

Protein

• UniProt ID: Q96DH6
• Protein name: RNA-binding protein Musashi homolog 2 (Musashi-2)
• Protein function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
• PDB: 6C8U, 6DBP, 6NTY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	23 → 92	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	112 → 181	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous; detected at low levels. {ECO:0000269|PubMed:12649177}.
• Sequence:

  MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKR
  SRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSAN
  TVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMV
  ECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQ
  FPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYIS
  AASPQPGSGFGHGIAGPLIATAFTNGYH

• Sequence length: 328

Pathways

KEGG:

mRNA surveillance pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANNABIS DEPENDENCE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CLONAL HEMATOPOIESIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Adenocarcinoma of Lung	Associate	34145929	★☆☆☆☆ Found in Text Mining only
Adenoma	Associate	34237057	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	27941885, 35589867	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Stimulate	24305552	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	26775684, 30604502, 32828126, 34237057, 40302097	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Associate	28542303	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	28542303	★☆☆☆☆ Found in Text Mining only
Dyslexia	Associate	23190410	★☆☆☆☆ Found in Text Mining only
Endometriosis	Associate	35269992	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	34047477	★☆☆☆☆ Found in Text Mining only
Glioma	Associate	34047477	★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Associate	37107676	★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Associate	28542303	★☆☆☆☆ Found in Text Mining only
Leukemia	Stimulate	21084860	★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	29641991, 30126842	★☆☆☆☆ Found in Text Mining only
Leukemia Myelogenous Chronic BCR ABL Positive	Stimulate	21084860, 26944313	★☆☆☆☆ Found in Text Mining only
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	22784712, 30126842	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Stimulate	29641991	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Accelerated Phase	Associate	21084860	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	21084860, 21753187, 22784712, 26308531, 30126842, 34862757	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	23683495	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	26775684, 40302097	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Associate	27322953	★☆☆☆☆ Found in Text Mining only
Lymphoma	Associate	36167829	★☆☆☆☆ Found in Text Mining only
Lymphoma B Cell	Associate	36167829	★☆☆☆☆ Found in Text Mining only
Mallory Weiss Syndrome	Associate	37107676	★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Inhibit	22784712	★☆☆☆☆ Found in Text Mining only
Necrosis	Associate	35269992	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	26775684, 34237057	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	32606289	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	35102250, 40302097	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	18815193, 26775684, 29073938, 30126842, 30367664, 31870844, 32779876, 34145929, 34768932, 35102250, 37107676	★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	34237057	★☆☆☆☆ Found in Text Mining only
Neurofibrosarcoma	Associate	32606289	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	32633342	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	31957818, 34768932	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	32779876	★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Neoplasms	Associate	31053152, 32606289	★☆☆☆☆ Found in Text Mining only
Polyps	Stimulate	34237057	★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	30126842	★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	37801708	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	22294438	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	31878037	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	35073459	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	35102250	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Stimulate	27322953	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	29073938	★☆☆☆☆ Found in Text Mining only
Weight Gain	Associate	33550919	★☆☆☆☆ Found in Text Mining only