Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1240
Gene name Gene Name - the full gene name approved by the HGNC.
Chemerin chemokine-like receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CMKLR1
Synonyms (NCBI Gene) Gene synonyms aliases
CHEMERINR, ChemR23, DEZ, ERV1, RVER1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q23.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT710975 hsa-miR-3127-3p HITS-CLIP 19536157
MIRT710974 hsa-miR-6756-3p HITS-CLIP 19536157
MIRT710973 hsa-miR-5088-3p HITS-CLIP 19536157
MIRT710972 hsa-miR-3183 HITS-CLIP 19536157
MIRT710971 hsa-miR-4723-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development TAS 9144535
GO:0002430 Process Complement receptor mediated signaling pathway IBA 21873635
GO:0004875 Function Complement receptor activity IBA 21873635
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0004930 Function G protein-coupled receptor activity NAS 9603476
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602351 2121 ENSG00000174600
Protein
UniProt ID Q99788
Protein name Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)
Protein function Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses
PDB 7YKD , 8SG1 , 8ZJG , 9L3W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 57 316 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array o
Sequence
Sequence length 373
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Class A/1 (Rhodopsin-like receptors)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
21483023
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder 22796467 ClinVar
Bipolar Disorder Bipolar Disorder GWAS
Cleft Lip With Or Without Cleft Palate Cleft Lip With Or Without Cleft Palate GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 31912564
Arthritis Reactive Associate 24689495
Arthritis Rheumatoid Associate 21959042, 33508012
Atherosclerosis Associate 24779513
Carcinoma Non Small Cell Lung Associate 21483023
Chylomicron retention disease Associate 21483023
Colorectal Neoplasms Associate 34946244
COVID 19 Associate 36032171
Death Associate 21483023
Diabetes Mellitus Type 2 Stimulate 27548138