Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
1240
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Chemerin chemokine-like receptor 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
CMKLR1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
CHEMERINR, ChemR23, DEZ, ERV1, RVER1 |
Chromosome
Chromosome number
|
12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q23.3 |
UniProt ID |
Q99788
|
Protein name |
Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ) |
Protein function |
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses |
PDB |
7YKD
,
8SG1
,
8ZJG
,
9L3W
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00001
|
7tm_1 |
57 → 316 |
7 transmembrane receptor (rhodopsin family) |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array o |
Sequence |
|
Sequence length |
373 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Lung carcinoma |
Non-Small Cell Lung Carcinoma |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 View all (44 more) |
21483023 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Mental depression |
Mental Depression, Depressive disorder |
|
22796467 |
ClinVar |
Bipolar Disorder |
Bipolar Disorder |
|
|
GWAS |
Cleft Lip With Or Without Cleft Palate |
Cleft Lip With Or Without Cleft Palate |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Alzheimer Disease |
Associate
|
31912564 |
Arthritis Reactive |
Associate
|
24689495 |
Arthritis Rheumatoid |
Associate
|
21959042, 33508012 |
Atherosclerosis |
Associate
|
24779513 |
Carcinoma Non Small Cell Lung |
Associate
|
21483023 |
Chylomicron retention disease |
Associate
|
21483023 |
Colorectal Neoplasms |
Associate
|
34946244 |
COVID 19 |
Associate
|
36032171 |
Death |
Associate
|
21483023 |
Diabetes Mellitus Type 2 |
Stimulate
|
27548138 |
Diabetes Mellitus Type 2 |
Associate
|
27994073 |
Endometriosis |
Associate
|
34318471 |
Fatty Liver Alcoholic |
Associate
|
27548138 |
Heel Spur |
Associate
|
24689495 |
Hepatitis C Chronic |
Associate
|
25121101 |
Inflammation |
Associate
|
16904155, 27239101, 27548138, 31912564, 33508012, 34318471, 35411569, 40552467 |
Insulin Resistance |
Associate
|
27239101, 33508012 |
Lichen Planus Oral |
Associate
|
17202316 |
Lung Neoplasms |
Associate
|
28619829 |
Neoplasms |
Associate
|
27092781, 34946244 |
Neoplasms |
Inhibit
|
39183397 |
Neoplasms Squamous Cell |
Associate
|
27092781 |
Obesity |
Stimulate
|
27239101 |
Psoriasis |
Associate
|
19114666 |
Respiratory Distress Syndrome |
Associate
|
36032171 |
Simian Acquired Immunodeficiency Syndrome |
Associate
|
16904155 |
Sjogren's Syndrome |
Associate
|
34847389 |
Squamous Cell Carcinoma of Head and Neck |
Inhibit
|
39183397 |
Vascular System Injuries |
Associate
|
34946244 |
|