Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1238
Gene name Gene Name - the full gene name approved by the HGNC.	Atypical chemokine receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ACKR2
Synonyms (NCBI Gene) Gene synonyms aliases	CCBP2, CCR10, CCR9, CMKBR9, D6, hD6
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cell

Show/Hide all(29)

miRTarBase ID	miRNA	Experiments	Reference
MIRT742159	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT742160	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT742161	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT742162	hsa-miR-2116-5p	HITS-CLIP	23824327
MIRT742163	hsa-miR-22-5p	HITS-CLIP	23824327
MIRT742164	hsa-miR-4273	HITS-CLIP	23824327
MIRT742165	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT742166	hsa-miR-4677-5p	HITS-CLIP	23824327
MIRT742167	hsa-miR-375	HITS-CLIP	23824327
MIRT742168	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT742169	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT742159	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT742160	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT742169	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT742159	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT742160	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT742167	hsa-miR-375	HITS-CLIP	23824327
MIRT742168	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT742169	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT755176	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT755177	hsa-miR-3200-5p	PAR-CLIP	23592263
MIRT755178	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT755179	hsa-miR-5681a	PAR-CLIP	23592263
MIRT755180	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT755181	hsa-miR-1236-5p	PAR-CLIP	23592263
MIRT755182	hsa-miR-4765	PAR-CLIP	23592263
MIRT755183	hsa-miR-488-3p	PAR-CLIP	23592263
MIRT755184	hsa-miR-4520-3p	PAR-CLIP	23592263
MIRT755185	hsa-miR-4520-2-3p	PAR-CLIP	23592263

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004950	Function	Chemokine receptor activity	TAS	9364936
GO:0005044	Function	Scavenger receptor activity	IMP	23633677
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005884	Component	Actin filament	IDA	23633677
GO:0005886	Component	Plasma membrane	IDA	23633677
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0006935	Process	Chemotaxis	TAS	9364936
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007275	Process	Multicellular organism development	TAS	9364936
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0016493	Function	C-C chemokine receptor activity	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IBA	21873635
GO:0019957	Function	C-C chemokine binding	IBA	21873635
GO:0031965	Component	Nuclear membrane	IDA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0055037	Component	Recycling endosome	IEA
GO:0060326	Process	Cell chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA

MIM	HGNC	e!Ensembl
602648	1565	ENSG00000144648

Protein

UniProt ID

O00590

Protein name

Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6)

Protein function

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation,

PDB

8GO9 , 8J8V , 8J8Z

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	63 → 312	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intesti

Sequence

MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLG
LSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMV
STLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDM
VFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRL
RPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESI
AFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMT
GMNDLGERQSENYPNKEDVGNKSA

Sequence length

384

Interactions

View interactions

	Reactome
			Chemokine receptors bind chemokines

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	25340798

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma	Inhibit	33374792
Arthritis Psoriatic	Stimulate	37131254
Breast Neoplasms	Associate	26314842, 30358125
Carcinoma Non Small Cell Lung	Associate	37056937
Colonic Neoplasms	Associate	33374792
Colorectal Neoplasms	Associate	33374792
Coronary Disease	Associate	23314186
Inflammation	Associate	28486662, 37131254
Joint Diseases	Stimulate	28486662
Lung Neoplasms	Associate	37056937
Lymphatic Metastasis	Associate	30358125
Migraine without Aura	Stimulate	28486662
Neoplasm Metastasis	Associate	37056937
Neoplasms	Associate	33374792
Polyps	Inhibit	33374792
Pre Eclampsia	Associate	27780270
Psoriasis	Stimulate	28486662, 37131254

ACKR2 (atypical chemokine receptor 2)