FSD2 (fibronectin type III and SPRY domain containing 2)

Gene

• Entrez ID: 123722
• Gene name: Fibronectin type III and SPRY domain containing 2
• Gene symbol: FSD2
• Synonyms (NCBI Gene): SPRYD1
• Chromosome: 15
• Chromosome location: 15q25.2
• Summary: This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT675131	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT675132	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT675130	hsa-miR-4679	HITS-CLIP	23824327
MIRT675129	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT675127	hsa-miR-4770	HITS-CLIP	23824327
MIRT675128	hsa-miR-6088	HITS-CLIP	23824327
MIRT675126	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT675125	hsa-miR-1273f	HITS-CLIP	23824327
MIRT675124	hsa-miR-924	HITS-CLIP	23824327
MIRT675123	hsa-miR-4534	HITS-CLIP	23824327
MIRT675122	hsa-miR-8082	HITS-CLIP	23824327
MIRT675121	hsa-miR-1289	HITS-CLIP	23824327
MIRT675120	hsa-miR-4294	HITS-CLIP	23824327
MIRT675119	hsa-miR-7641	HITS-CLIP	23824327
MIRT675118	hsa-miR-3198	HITS-CLIP	23824327
MIRT675117	hsa-miR-4309	HITS-CLIP	23824327
MIRT675116	hsa-miR-8055	HITS-CLIP	23824327
MIRT675115	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615776	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615775	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615774	hsa-miR-6128	HITS-CLIP	23824327
MIRT615773	hsa-miR-27a-5p	HITS-CLIP	23824327
MIRT615772	hsa-miR-4775	HITS-CLIP	23824327
MIRT615771	hsa-miR-1299	HITS-CLIP	23824327
MIRT615770	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615769	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615768	hsa-miR-5706	HITS-CLIP	23824327
MIRT615771	hsa-miR-1299	HITS-CLIP	27418678
MIRT615772	hsa-miR-4775	HITS-CLIP	27418678
MIRT615769	hsa-miR-4782-5p	HITS-CLIP	27418678
MIRT615770	hsa-miR-516b-5p	HITS-CLIP	27418678
MIRT615768	hsa-miR-5706	HITS-CLIP	27418678
MIRT615776	hsa-miR-590-3p	HITS-CLIP	27418678
MIRT615774	hsa-miR-6128	HITS-CLIP	27418678
MIRT615775	hsa-miR-875-3p	HITS-CLIP	27418678
MIRT675131	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT675132	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT675130	hsa-miR-4679	HITS-CLIP	23824327
MIRT675129	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT675127	hsa-miR-4770	HITS-CLIP	23824327
MIRT675128	hsa-miR-6088	HITS-CLIP	23824327
MIRT675126	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT675125	hsa-miR-1273f	HITS-CLIP	23824327
MIRT675124	hsa-miR-924	HITS-CLIP	23824327
MIRT675123	hsa-miR-4534	HITS-CLIP	23824327
MIRT675122	hsa-miR-8082	HITS-CLIP	23824327
MIRT675121	hsa-miR-1289	HITS-CLIP	23824327
MIRT675120	hsa-miR-4294	HITS-CLIP	23824327
MIRT675119	hsa-miR-7641	HITS-CLIP	23824327
MIRT675118	hsa-miR-3198	HITS-CLIP	23824327
MIRT675117	hsa-miR-4309	HITS-CLIP	23824327
MIRT675116	hsa-miR-8055	HITS-CLIP	23824327
MIRT675115	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615776	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615775	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615774	hsa-miR-6128	HITS-CLIP	23824327
MIRT615773	hsa-miR-27a-5p	HITS-CLIP	23824327
MIRT615772	hsa-miR-4775	HITS-CLIP	23824327
MIRT615771	hsa-miR-1299	HITS-CLIP	23824327
MIRT615770	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615769	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615768	hsa-miR-5706	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0016529	Component	Sarcoplasmic reticulum	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A1L4K1
• Protein name: Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00041	fn3	373 → 460	Fibronectin type III domain	Domain
  PF00622	SPRY	621 → 740	SPRY domain	Family

• Sequence:

  MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGD
  GKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDW
  RLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFC
  VTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEV
  FITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLD
  TCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVE
  QLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTD
  QAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIR
  SCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYII
  YVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSP
  SDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRH
  TFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHE
  FVHPCFSLEKPGCLKVHNGISMPKHVTFY

• Sequence length: 749