CCR7 (C-C motif chemokine receptor 7)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1236
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine receptor 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCR7
Synonyms (NCBI Gene) Gene synonyms aliases
BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expres
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(36)
miRTarBase ID miRNA Experiments Reference
MIRT006813 hsa-let-7a-5p Luciferase reporter assay, Northern blot, qRT-PCR, Western blot 22251626
MIRT018216 hsa-miR-335-5p Microarray 18185580
MIRT440980 hsa-miR-21-5p HITS-CLIP 22473208
MIRT440980 hsa-miR-21-5p HITS-CLIP 22473208
MIRT732313 hsa-miR-199a-5p Luciferase reporter assay, qRT-PCR 27814720
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
Transcription factor Regulation Reference
EPAS1 Activation 19305150
HIF1A Activation 17178876;19305150
KLF2 Unknown 20146713
NFKB1 Activation 11830455;19164127
NFKB1 Unknown 22158872
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(97)
GO ID Ontology Definition Evidence Reference
GO:0001768 Process Establishment of T cell polarity IC 12729902
GO:0001954 Process Positive regulation of cell-matrix adhesion IC 15569314
GO:0002407 Process Dendritic cell chemotaxis IC 15778365
GO:0002408 Process Myeloid dendritic cell chemotaxis IDA 11602640, 14592837
GO:0002606 Process Positive regulation of dendritic cell antigen processing and presentation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600242 1608 ENSG00000126353
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P32248
Protein name C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)
Protein function Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
PDB 6QZH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 75 → 326 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Sequence
Sequence length 378
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (9)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Asthma Atopic asthma, Asthma (age of onset), Asthma, Asthma (childhood onset) N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Diabetes Type 1 diabetes N/A N/A GWAS
Show/Hide Text Mining Associations (190)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Achalasia Addisonianism Alacrimia syndrome Associate 34777635
Adenocarcinoma of Lung Associate 23922113
Anemia Sickle Cell Associate 24779034, 32267841
Aneurysm Ruptured Associate 38538213
Anti N Methyl D Aspartate Receptor Encephalitis Associate 36544777
Aortic Aneurysm Abdominal Associate 29439675, 34777635
Arthritis Associate 33168080, 34691053, 40534874
Arthritis Juvenile Associate 15743472
Arthritis Psoriatic Stimulate 32733468
Arthritis Psoriatic Associate 34681660